SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8QDX5

- Q8QDX5_9HIV1

UniProt

Q8QDX5 - Q8QDX5_9HIV1

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Submitted name: Envelope glycoprotein
Gene
env
Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity.SAAS annotations
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity.SAAS annotations

GO - Molecular functioni

  1. structural molecule activity Source: InterPro
Complete GO annotation...

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotations, Fusion of virus membrane with host membraneSAAS annotations, Host-virus interaction, Viral attachment to host cellSAAS annotations, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Submitted name:
Envelope glycoproteinImported
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. integral component of membrane Source: UniProtKB-KW
  4. viral envelope Source: UniProtKB-KW
  5. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endosomeSAAS annotations, Viral envelope proteinUniRule annotationImported, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotations

Structurei

3D structure databases

ProteinModelPortaliQ8QDX5.

Family & Domainsi

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Fragment.

Q8QDX5-1 [UniParc]FASTAAdd to Basket

« Hide

KEIRKHLWRW GTLFLGMLMT CNATENLWVT VYYGVPVWKE ATTTLFCASD    50
AKAYSKEVHN VWATYACVPT DPSPQEIPLE NVTENFNMGK NNMVEQMHED 100
IISLWDQSLK PCVKLTPLCV TLNCTDLKKN VTNNNTISPE MREMKNCSFN 150
ITTGLRNKVK NEYALFYELD VVQINNDSYR LISCNTSVVT QACPKISFEP 200
IPIHYCAPAG FAILKCNDKE FNGTGPCTNV STVQCTHGIK PVVSTQLLLN 250
GSLAEKEVVI RSVNFTDNTK TIIVQLTEPV EINCTRPNNN TRKGIHIGPG 300
RAFYVTGDII GDIRQAHCNI STTKWNNTLK QIGDKLKEQF GNKTIVFNQS 350
SGGDPEIVMH SFNCGGEFFY CNTTGLFNST WNGTESNNTI TLPCRIKQII 400
NMWQEVGKAM YAPPIAGQIR CSSNITGLLL TRDGGDQSNG TEIFRPGGGD 450
MRDNWRSELY KYKVVKIEPL GVAPAKAKRR VVQREKRAVG IGAVFLGFLG 500
AAGSTMGAAS ITLTVQARQL LSGIVQQQNN LLRAIEAQQH LLQLT 545
Length:545
Mass (Da):60,567
Last modified:June 1, 2002 - v1
Checksum:iCD3457DF29CDEEC7
GO

Non-terminal residue

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei545 – 5451Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF414002 Genomic DNA. Translation: AAL78482.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF414002 Genomic DNA. Translation: AAL78482.1 .

3D structure databases

ProteinModelPortali Q8QDX5.
ModBasei Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and analysis of full-length genome of HIV type 1 strains prevalent in countries of the former Soviet Union."
    Masharsky A.E., Klimov N.A., Kozlov A.P.
    AIDS Res. Hum. Retroviruses 19:933-939(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 98BY10443Imported.

Entry informationi

Entry nameiQ8QDX5_9HIV1
AccessioniPrimary (citable) accession number: Q8QDX5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi