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Q8QDX5 (Q8QDX5_9HIV1) Unreviewed, UniProtKB/TrEMBL

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein names
Gene names
Name:env EMBL AAL78482.1
OrganismHuman immunodeficiency virus 1 EMBL AAL78482.1
Taxonomic identifier11676 [NCBI]
Taxonomic lineageVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostHomo sapiens (Human) [TaxID: 9606]

Protein attributes

Sequence length545 AA.
Sequence statusFragment.
Protein existenceInferred from homology

General annotation (Comments)

Function

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. SAAS SAAS000328

The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity. SAAS SAAS000328

Subcellular location

Virion membrane; Single-pass type I membrane protein. Host cell membrane; Single-pass type I membrane protein. Host endosome membrane; Single-pass type I membrane protein By similarity SAAS SAAS000328.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Experimental info

Non-terminal residue11 EMBL AAL78482.1
Non-terminal residue5451 EMBL AAL78482.1

Sequences

Sequence LengthMass (Da)Tools
Q8QDX5 [UniParc].

Last modified June 1, 2002. Version 1.
Checksum: CD3457DF29CDEEC7

FASTA54560,567
        10         20         30         40         50         60 
KEIRKHLWRW GTLFLGMLMT CNATENLWVT VYYGVPVWKE ATTTLFCASD AKAYSKEVHN 

        70         80         90        100        110        120 
VWATYACVPT DPSPQEIPLE NVTENFNMGK NNMVEQMHED IISLWDQSLK PCVKLTPLCV 

       130        140        150        160        170        180 
TLNCTDLKKN VTNNNTISPE MREMKNCSFN ITTGLRNKVK NEYALFYELD VVQINNDSYR 

       190        200        210        220        230        240 
LISCNTSVVT QACPKISFEP IPIHYCAPAG FAILKCNDKE FNGTGPCTNV STVQCTHGIK 

       250        260        270        280        290        300 
PVVSTQLLLN GSLAEKEVVI RSVNFTDNTK TIIVQLTEPV EINCTRPNNN TRKGIHIGPG 

       310        320        330        340        350        360 
RAFYVTGDII GDIRQAHCNI STTKWNNTLK QIGDKLKEQF GNKTIVFNQS SGGDPEIVMH 

       370        380        390        400        410        420 
SFNCGGEFFY CNTTGLFNST WNGTESNNTI TLPCRIKQII NMWQEVGKAM YAPPIAGQIR 

       430        440        450        460        470        480 
CSSNITGLLL TRDGGDQSNG TEIFRPGGGD MRDNWRSELY KYKVVKIEPL GVAPAKAKRR 

       490        500        510        520        530        540 
VVQREKRAVG IGAVFLGFLG AAGSTMGAAS ITLTVQARQL LSGIVQQQNN LLRAIEAQQH 


LLQLT 

« Hide

References

[1]"Molecular cloning and analysis of full-length genome of HIV type 1 strains prevalent in countries of the former Soviet Union."
Masharsky A.E., Klimov N.A., Kozlov A.P.
AIDS Res. Hum. Retroviruses 19:933-939(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 98BY10443 EMBL AAL78482.1.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF414002 Genomic DNA. Translation: AAL78482.1.

3D structure databases

ProteinModelPortalQ8QDX5.
ModBaseSearch...
MobiDBSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Family and domain databases

Gene3D2.170.40.20. 2 hits.
InterProIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMSSF56502. SSF56502. 2 hits.
ProtoNetSearch...

Entry information

Entry nameQ8QDX5_9HIV1
AccessionPrimary (citable) accession number: Q8QDX5
Entry history
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)