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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed-Annotation score: Annotation score: 2 out of 5-Protein predictedi

Functioni

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160SAAS annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

  • Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation
  • Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Host endosomeSAAS annotation, MembraneSAAS annotation, Viral envelope proteinUniRule annotationImported, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ8QDX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Fragment.

Q8QDX5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
KEIRKHLWRW GTLFLGMLMT CNATENLWVT VYYGVPVWKE ATTTLFCASD
60 70 80 90 100
AKAYSKEVHN VWATYACVPT DPSPQEIPLE NVTENFNMGK NNMVEQMHED
110 120 130 140 150
IISLWDQSLK PCVKLTPLCV TLNCTDLKKN VTNNNTISPE MREMKNCSFN
160 170 180 190 200
ITTGLRNKVK NEYALFYELD VVQINNDSYR LISCNTSVVT QACPKISFEP
210 220 230 240 250
IPIHYCAPAG FAILKCNDKE FNGTGPCTNV STVQCTHGIK PVVSTQLLLN
260 270 280 290 300
GSLAEKEVVI RSVNFTDNTK TIIVQLTEPV EINCTRPNNN TRKGIHIGPG
310 320 330 340 350
RAFYVTGDII GDIRQAHCNI STTKWNNTLK QIGDKLKEQF GNKTIVFNQS
360 370 380 390 400
SGGDPEIVMH SFNCGGEFFY CNTTGLFNST WNGTESNNTI TLPCRIKQII
410 420 430 440 450
NMWQEVGKAM YAPPIAGQIR CSSNITGLLL TRDGGDQSNG TEIFRPGGGD
460 470 480 490 500
MRDNWRSELY KYKVVKIEPL GVAPAKAKRR VVQREKRAVG IGAVFLGFLG
510 520 530 540
AAGSTMGAAS ITLTVQARQL LSGIVQQQNN LLRAIEAQQH LLQLT
Length:545
Mass (Da):60,567
Last modified:June 1, 2002 - v1
Checksum:iCD3457DF29CDEEC7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei545 – 5451Imported

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414002 Genomic DNA. Translation: AAL78482.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF414002 Genomic DNA. Translation: AAL78482.1.

3D structure databases

ProteinModelPortaliQ8QDX5.
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Molecular cloning and analysis of full-length genome of HIV type 1 strains prevalent in countries of the former Soviet Union."
    Masharsky A.E., Klimov N.A., Kozlov A.P.
    AIDS Res. Hum. Retroviruses 19:933-939(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 98BY10443Imported.

Entry informationi

Entry nameiQ8QDX5_9HIV1
AccessioniPrimary (citable) accession number: Q8QDX5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: April 1, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.