Q8QDX5 (Q8QDX5_9HIV1) Unreviewed, UniProtKB/TrEMBL
Last modified February 19, 2014. Version 75. History...
Names and origin
|Protein names||Submitted name:|
Envelope glycoprotein EMBL AAL78482.1
|Organism||Human immunodeficiency virus 1 EMBL AAL78482.1|
|Taxonomic identifier||11676 [NCBI]|
|Taxonomic lineage||Viruses › Retro-transcribing viruses › Retroviridae › Orthoretrovirinae › Lentivirus › Primate lentivirus group|
|Virus host||Homo sapiens (Human) [TaxID: 9606]|
|Sequence length||545 AA.|
|Protein existence||Inferred from homology|
General annotation (Comments)
The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface By similarity. SAAS SAAS000328
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves By similarity. SAAS SAAS000328
Sequence annotation (Features)
|||"Molecular cloning and analysis of full-length genome of HIV type 1 strains prevalent in countries of the former Soviet Union."|
Masharsky A.E., Klimov N.A., Kozlov A.P.
AIDS Res. Hum. Retroviruses 19:933-939(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE.
Strain: 98BY10443 EMBL AAL78482.1.
|AF414002 Genomic DNA. Translation: AAL78482.1.|
3D structure databases
Protocols and materials databases
Family and domain databases
|Gene3D||220.127.116.11. 2 hits. |
|InterPro||IPR000777. HIV1_GP160. |
|Pfam||PF00516. GP120. 1 hit. |
PF00517. GP41. 1 hit.
|SUPFAM||SSF56502. SSF56502. 2 hits. |
|Accession||Primary (citable) accession number: Q8QDX5|
|Entry status||Unreviewed (UniProtKB/TrEMBL)|