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Q8QDX5

- Q8QDX5_9HIV1

UniProt

Q8QDX5 - Q8QDX5_9HIV1

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Protein

Envelope glycoprotein gp160

Gene

env

Organism
Human immunodeficiency virus 1
Status
Unreviewed - Annotation score: 2 out of 5- Protein predictedi

Functioni

The envelope glyprotein gp160 precursor down-modulates cell surface CD4 antigen by interacting with it in the endoplasmic reticulum and blocking its transport to the cell surface.SAAS annotation
The gp120-gp41 heterodimer allows rapid transcytosis of the virus through CD4 negative cells such as simple epithelial monolayers of the intestinal, rectal and endocervical epithelial barriers. Both gp120 and gp41 specifically recognize glycosphingolipids galactosyl-ceramide (GalCer) or 3' sulfo-galactosyl-ceramide (GalS) present in the lipid rafts structures of epithelial cells. Binding to these alternative receptors allows the rapid transcytosis of the virus through the epithelial cells. This transcytotic vesicle-mediated transport of virions from the apical side to the basolateral side of the epithelial cells does not involve infection of the cells themselves.SAAS annotation

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. apoptotic process Source: UniProtKB-KW
  2. membrane fusion involved in viral entry into host cell Source: UniProtKB-KW
  3. virion attachment to host cell Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ApoptosisSAAS annotation, Fusion of virus membrane with host membraneSAAS annotation, Host-virus interaction, Viral attachment to host cellSAAS annotation, Viral penetration into host cytoplasm, Virus entry into host cell

Names & Taxonomyi

Protein namesi
Recommended name:
Envelope glycoprotein gp160SAAS annotation
Gene namesi
Name:envImported
OrganismiHuman immunodeficiency virus 1Imported
Taxonomic identifieri11676 [NCBI]
Taxonomic lineageiVirusesRetro-transcribing virusesRetroviridaeOrthoretrovirinaeLentivirusPrimate lentivirus group
Virus hostiHomo sapiens (Human) [TaxID: 9606]

Subcellular locationi

Virion membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host cell membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation. Host endosome membrane SAAS annotation; Single-pass type I membrane protein SAAS annotation

GO - Cellular componenti

  1. host cell endosome membrane Source: UniProtKB-SubCell
  2. host cell plasma membrane Source: UniProtKB-SubCell
  3. viral envelope Source: UniProtKB-KW
  4. virion membrane Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Host endosomeSAAS annotation, Viral envelope proteinUniRule annotationImported, Virion

Pathology & Biotechi

Keywords - Diseasei

AIDSUniRule annotation

PTM / Processingi

Keywords - PTMi

Disulfide bondSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ8QDX5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Family and domain databases

Gene3Di2.170.40.20. 2 hits.
InterProiIPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view]
PfamiPF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view]
SUPFAMiSSF56502. SSF56502. 2 hits.

Sequencei

Sequence statusi: Fragment.

Q8QDX5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
KEIRKHLWRW GTLFLGMLMT CNATENLWVT VYYGVPVWKE ATTTLFCASD
60 70 80 90 100
AKAYSKEVHN VWATYACVPT DPSPQEIPLE NVTENFNMGK NNMVEQMHED
110 120 130 140 150
IISLWDQSLK PCVKLTPLCV TLNCTDLKKN VTNNNTISPE MREMKNCSFN
160 170 180 190 200
ITTGLRNKVK NEYALFYELD VVQINNDSYR LISCNTSVVT QACPKISFEP
210 220 230 240 250
IPIHYCAPAG FAILKCNDKE FNGTGPCTNV STVQCTHGIK PVVSTQLLLN
260 270 280 290 300
GSLAEKEVVI RSVNFTDNTK TIIVQLTEPV EINCTRPNNN TRKGIHIGPG
310 320 330 340 350
RAFYVTGDII GDIRQAHCNI STTKWNNTLK QIGDKLKEQF GNKTIVFNQS
360 370 380 390 400
SGGDPEIVMH SFNCGGEFFY CNTTGLFNST WNGTESNNTI TLPCRIKQII
410 420 430 440 450
NMWQEVGKAM YAPPIAGQIR CSSNITGLLL TRDGGDQSNG TEIFRPGGGD
460 470 480 490 500
MRDNWRSELY KYKVVKIEPL GVAPAKAKRR VVQREKRAVG IGAVFLGFLG
510 520 530 540
AAGSTMGAAS ITLTVQARQL LSGIVQQQNN LLRAIEAQQH LLQLT
Length:545
Mass (Da):60,567
Last modified:June 1, 2002 - v1
Checksum:iCD3457DF29CDEEC7
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Non-terminal residuei1 – 11Imported
Non-terminal residuei545 – 5451Imported

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF414002 Genomic DNA. Translation: AAL78482.1.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF414002 Genomic DNA. Translation: AAL78482.1 .

3D structure databases

ProteinModelPortali Q8QDX5.
ModBasei Search...
MobiDBi Search...

Protocols and materials databases

Structural Biology Knowledgebase Search...

Family and domain databases

Gene3Di 2.170.40.20. 2 hits.
InterProi IPR000777. HIV1_GP160.
IPR000328. Retroviral_envelope_protein.
[Graphical view ]
Pfami PF00516. GP120. 1 hit.
PF00517. GP41. 1 hit.
[Graphical view ]
SUPFAMi SSF56502. SSF56502. 2 hits.
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning and analysis of full-length genome of HIV type 1 strains prevalent in countries of the former Soviet Union."
    Masharsky A.E., Klimov N.A., Kozlov A.P.
    AIDS Res. Hum. Retroviruses 19:933-939(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
    Strain: 98BY10443Imported.

Entry informationi

Entry nameiQ8QDX5_9HIV1
AccessioniPrimary (citable) accession number: Q8QDX5
Entry historyi
Integrated into UniProtKB/TrEMBL: June 1, 2002
Last sequence update: June 1, 2002
Last modified: October 29, 2014
This is version 78 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)