ID   Q8Q7Z9_9HIV1            Unreviewed;       207 AA.
AC   Q8Q7Z9;
DT   01-JUN-2002, integrated into UniProtKB/TrEMBL.
DT   01-JUN-2002, sequence version 1.
DT   27-MAR-2024, entry version 88.
DE   SubName: Full=Envelope glycoprotein {ECO:0000313|EMBL:BAB85748.1};
DE   Flags: Fragment;
GN   Name=env {ECO:0000313|EMBL:BAB85748.1};
OS   Human immunodeficiency virus 1.
OC   Viruses; Riboviria; Pararnavirae; Artverviricota; Revtraviricetes;
OC   Ortervirales; Retroviridae; Orthoretrovirinae; Lentivirus.
OX   NCBI_TaxID=11676 {ECO:0000313|EMBL:BAB85748.1};
OH   NCBI_TaxID=9606; Homo sapiens (Human).
RN   [1] {ECO:0000313|EMBL:BAB85748.1}
RP   NUCLEOTIDE SEQUENCE.
RA   Takeuchi H., Suzuki Y., Daar E.S., Koyanagi Y.;
RT   "Multiple HIV-1 infection of homogenous R5 and varied X4 viruses in a case
RT   with acute infection.";
RL   Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0007829|PDB:2NY6}
RP   X-RAY CRYSTALLOGRAPHY (2.80 ANGSTROMS) OF 71-173, GLYCOSYLATION AT ASN-110;
RP   ASN-138; ASN-152; ASN-165 AND ASN-171, AND DISULFIDE BONDS.
RX   PubMed=17301785; DOI=10.1038/nature05580;
RA   Zhou T., Xu L., Dey B., Hessell A.J., Van Ryk D., Xiang S.H., Yang X.,
RA   Zhang M.Y., Zwick M.B., Arthos J., Burton D.R., Dimitrov D.S., Sodroski J.,
RA   Wyatt R., Nabel G.J., Kwong P.D.;
RT   "Structural definition of a conserved neutralization epitope on HIV-1
RT   gp120.";
RL   Nature 445:732-737(2007).
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DR   EMBL; AB077815; BAB85748.1; -; Genomic_DNA.
DR   PDB; 2NY6; X-ray; 2.80 A; A=71-173.
DR   PDBsum; 2NY6; -.
DR   SMR; Q8Q7Z9; -.
DR   GlyCosmos; Q8Q7Z9; 5 sites, No reported glycans.
DR   EvolutionaryTrace; Q8Q7Z9; -.
DR   GO; GO:0019031; C:viral envelope; IEA:UniProtKB-KW.
DR   Gene3D; 2.170.40.20; Human immunodeficiency virus 1, Gp160, envelope glycoprotein; 1.
DR   InterPro; IPR036377; Gp120_core_sf.
DR   InterPro; IPR000777; HIV1_Gp120.
DR   Pfam; PF00516; GP120; 1.
DR   SUPFAM; SSF56502; gp120 core; 1.
PE   1: Evidence at protein level;
KW   3D-structure {ECO:0007829|PDB:2NY6};
KW   Viral envelope protein {ECO:0000313|EMBL:BAB85748.1};
KW   Virion {ECO:0000313|EMBL:BAB85748.1}.
FT   DOMAIN          1..207
FT                   /note="Human immunodeficiency virus 1 envelope glycoprotein
FT                   Gp120"
FT                   /evidence="ECO:0000259|Pfam:PF00516"
FT   CARBOHYD        87
FT                   /note="N-acetyl-D-glucosamine 1"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        110
FT                   /note="N-acetyl-D-glucosamine 2"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        110
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        138
FT                   /note="N-acetyl-D-glucosamine 1"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        138
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        146
FT                   /note="N-acetyl-D-glucosamine 3"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        152
FT                   /note="N-acetyl-D-glucosamine 4"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        152
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        165
FT                   /note="N-acetyl-D-glucosamine 3"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        165
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        171
FT                   /note="N-acetyl-D-glucosamine 5"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   CARBOHYD        171
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   DISULFID        94..123
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   DISULFID        104..115
FT                   /evidence="ECO:0007829|PDB:2NY6"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:BAB85748.1"
FT   NON_TER         207
FT                   /evidence="ECO:0000313|EMBL:BAB85748.1"
SQ   SEQUENCE   207 AA;  22760 MW;  BB1255A4F09ADE69 CRC64;
     LCVSLKCTDL KNDTNTNSSS GRMIMEKGEI KNCSFNISTS KRGKVQKEYA FFYKLDIIPI
     DNDTTSYTLT SCNTSVITQA CPKVSFEPIP IHYCAPAGFA ILKCNNKTFN GTGPCTNVST
     VQCTHGIRPV VSTQLLLNGS LAEEEVVIRS VNFTDNAKTI IVQLNTSVEI NCTRPTNNTR
     KKIRIQRGPG RAFVTIGKIG NMRQAHC
//