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Protein

AMP phosphorylase

Gene

MM_0087

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO.UniRule annotation

Catalytic activityi

AMP + phosphate = adenine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
CMP + phosphate = cytosine + alpha-D-ribose 1,5-bisphosphate.UniRule annotation
UMP + phosphate = uracil + alpha-D-ribose 1,5-bisphosphate.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei168AMP; via amide nitrogenUniRule annotation1
Binding sitei203AMP; via amide nitrogenUniRule annotation1
Active sitei256Proton donorUniRule annotation1
Binding sitei264AMPUniRule annotation1
Binding sitei288AMPUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi194 – 199AMPUniRule annotation6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGlycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciMMAZ192952:G1FZI-90-MONOMER

Names & Taxonomyi

Protein namesi
Recommended name:
AMP phosphorylaseUniRule annotation (EC:2.4.2.57UniRule annotation)
Short name:
AMPpaseUniRule annotation
Alternative name(s):
Nucleoside monophosphate phosphorylaseUniRule annotation
Short name:
NMP phosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:MM_0087
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000590891 – 507AMP phosphorylaseAdd BLAST507

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_0087

Structurei

3D structure databases

ProteinModelPortaliQ8Q0P9
SMRiQ8Q0P9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02013 Archaea
COG0213 LUCA
HOGENOMiHOG000252767
KOiK18931
OMAiVHSIGGV
OrthoDBiPOG093Z01M3

Family and domain databases

Gene3Di3.40.1030.10, 1 hit
3.90.1170.30, 1 hit
HAMAPiMF_02132 AMP_phosphorylase, 1 hit
InterProiView protein in InterPro
IPR017713 AMP_phosphorylase
IPR009010 Asp_de-COase-like_dom_sf
IPR000312 Glycosyl_Trfase_fam3
IPR017459 Glycosyl_Trfase_fam3_N_dom
IPR036320 Glycosyl_Trfase_fam3_N_dom)sf
IPR035902 Nuc_phospho_transferase
IPR036566 PYNP-like_C_sf
IPR013102 PYNP_C
IPR017872 Pyrmidine_PPase_CS
IPR013466 Thymidine/AMP_Pase
IPR000053 Thymidine/pyrmidine_PPase
PANTHERiPTHR10515 PTHR10515, 1 hit
PfamiView protein in Pfam
PF02885 Glycos_trans_3N, 1 hit
PF00591 Glycos_transf_3, 1 hit
PF07831 PYNP_C, 1 hit
PIRSFiPIRSF000478 TP_PyNP, 1 hit
SMARTiView protein in SMART
SM00941 PYNP_C, 1 hit
SUPFAMiSSF47648 SSF47648, 1 hit
SSF50692 SSF50692, 1 hit
SSF52418 SSF52418, 1 hit
SSF54680 SSF54680, 1 hit
TIGRFAMsiTIGR03327 AMP_phos, 1 hit
TIGR02645 ARCH_P_rylase, 1 hit
PROSITEiView protein in PROSITE
PS00647 THYMID_PHOSPHORYLASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8Q0P9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMQLKLEHYN IKIGQHKVLL NIVDAKELGV NPGDRVRIRG HQSLSAIVDT
60 70 80 90 100
TDDMVPPGTL GVFTEVYEHF EDWDKPVEVV PSFRSKSAAV IKKMLDKKPV
110 120 130 140 150
VQDEIKMLVS DIVDENLSDV ELSAFITASY IHGMTDDEVE WLTRAMIDTG
160 170 180 190 200
DTIEFDTHPI MDKHSIGGVP GNKISLLIVP IVAANGLLIP KTSSRAITGA
210 220 230 240 250
GGTADLMEVL SPVEFSSQEV KEITEKVGGA LVWGGATNIA PADDKLIKIE
260 270 280 290 300
YPLSIDPYYQ MLASIMAKKG AIGADNVVMD IPVGPGTKVP TVQEGQKLAR
310 320 330 340 350
DLINLGHRLG MNVECAITYG SSPIGRRVGP SLEVKEAMKV LESMEGPNSL
360 370 380 390 400
IEKSAALAGI LLEMGGAAPR DQGKELALET LRSGKALEKM KQIIEAQGGD
410 420 430 440 450
PNIKSDDIQT GQYTADIFAS TDGYVMEFDN KWIIEIARLA GAPNDKGAGV
460 470 480 490 500
AIHKKRGEQV KKGDPILTIY AEKEIKLDNA LATAQRTNPI IVEGMLLRRI

PGTYGFQ
Length:507
Mass (Da):54,899
Last modified:October 1, 2002 - v1
Checksum:i439264B574089495
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA Translation: AAM29783.1
RefSeqiWP_011032041.1, NC_003901.1

Genome annotation databases

EnsemblBacteriaiAAM29783; AAM29783; MM_0087
GeneIDi24882594
KEGGimma:MM_0087
PATRICifig|192952.21.peg.100

Similar proteinsi

Entry informationi

Entry nameiAMPPA_METMA
AccessioniPrimary (citable) accession number: Q8Q0P9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 29, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health