Carbon monoxide dehydrogenase 1 - Methanosarcina mazei

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Reviewed, UniProtKB/Swiss-Prot Q8Q0L5 (COOS1_METMA)

Last modified June 16, 2009. Version 48. History...

Clusters with 100%, 90%, 50% identity |

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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein names

Recommended name:
    Carbon monoxide dehydrogenase 1
      Short name=CODH 1
    EC=1.2.99.2

Gene names

Name:	cooS1
Ordered Locus Names:	MM_0121

Organism

Methanosarcina mazei (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	628 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	CO + H₂O + A = CO₂ + AH₂.
Cofactor	Binds 3 4Fe-4S clusters per homodimer By similarity. Binds 2 nickel-iron-sulfur clusters per homodimer By similarity.
Subunit structure	Homodimer By similarity.
Domain	Cluster B is an all-cysteinyl-liganded 4Fe4S cluster; cluster C is a mixed Ni-Fe-S cluster which appears to be the active site of CO oxidation. Cluster D is also an all-cysteinyl-liganded 4Fe4S cluster that bridges the two subunits of the CODH dimer By similarity.
Sequence similarities	Belongs to the Ni-containing carbon monoxide dehydrogenase family.

Ontologies

Keywords
Ligand	4Fe-4S Iron Iron-sulfur Metal-binding Nickel
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	generation of precursor metabolites and energy Inferred from electronic annotation. Source: InterPro oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular function	4 iron, 4 sulfur cluster binding Inferred from electronic annotation. Source: UniProtKB-KW carbon-monoxide dehydrogenase (acceptor) activity Inferred from electronic annotation. Source: EC electron carrier activity Inferred from electronic annotation. Source: InterPro iron ion binding Inferred from electronic annotation. Source: UniProtKB-KW nickel ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

628

Carbon monoxide dehydrogenase 1

PRO_0000157145

Sites

Metal binding

1

Iron-sulfur 1 (4Fe-4S); shared with dimeric partner By similarity

Metal binding

1

Iron-sulfur 1 (4Fe-4S); shared with dimeric partner By similarity

Metal binding

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

1

Iron-sulfur 2 (4Fe-4S) By similarity

Metal binding

1

Nickel-iron-sulfur By similarity

Metal binding

1

Nickel-iron-sulfur By similarity

Metal binding

1

Nickel-iron-sulfur By similarity

Metal binding

1

Nickel-iron-sulfur By similarity

Metal binding

1

Nickel-iron-sulfur By similarity

Metal binding

1

Nickel-iron-sulfur By similarity

Sequences

Sequence

Length

Mass (Da)

Tools

Q8Q0L5-1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 477E826EC46CCA6E
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628

66,452

        10         20         30         40         50         60 
MGCKMKQTAF EKSIDPASQK MLEKAENEGI ETAWDRYEKQ LPQCSFGQLG ICCRNCNMGP 

        70         80         90        100        110        120 
CRIDPFGEGA EKGICGATAD IIVARNLLRM IAAGAAAHSD HARDAVLTFK KMTEGEAGSY 

       130        140        150        160        170        180 
GIKDKTKLFS LASEYGISLE GKSHEEVAGE LASALLAEFG KQEGPIQYTR RAPEARLRLW 

       190        200        210        220        230        240 
TSLGIEPRGV DREIVECMHR THIGVDNDAT HILLHGLRTS LSDGWGGSMI ATEIQDVLFG 

       250        260        270        280        290        300 
TPEPKKSTVN LGVLSHDKVN VIIHGHEPIL SEMIVQAAED PELLELAKEK GAAGINVAGI 

       310        320        330        340        350        360 
CCTGNETLMR HGTPIAGNFL QQELAVVTGA VEAMIVDVQC IMPALGNLTG CYHTKFISTS 

       370        380        390        400        410        420 
PKADFPGTVR MEFHEERAYD TAREIVRTAV ENFPNRNIEK VNIPEEKQEC MVGFSAEAIL 

       430        440        450        460        470        480 
KALGGSPAPL IDAIAGGAVK GIGAVVGCNN VKVQHNYGHV NLVKELIKNN VLVVTTGCNA 

       490        500        510        520        530        540 
IACAEAGLLV PEAAAQAGDG LKGVCEALGI PPVLHMGSCV DISRILVLAS AIAKSLGVDI 

       550        560        570        580        590        600 
SDLPAAGAAP EWMSEKAVSI GAYVVSSGVF TVLGTVPPVL GSQAVTALLT KGLDNVIGAS 

       610        620 
FAVEPDPFKA ANLMLEHIEG KRKALGLN

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.

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Gottschalk G.
J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88.

Cross-references

Sequence databases
	AE008384 Genomic DNA. Translation: AAM29817.1.
RefSeq	NP_632145.1.
3D structure databases
HSSP	HSSP built from PDB template 1JJY based on UniProtKB Q9F8A8.
ModBase	Search...
Genome annotation databases
GeneID	1478463.
GenomeReviews	Gene locus MM_0121 in contig AE008384_GR.
KEGG	mma:MM_0121.
NMPDR	fig\|192952.1.peg.121.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8Q0L5.
OMA	Q8Q0L5. MGPCRID.
Enzyme and pathway databases
BioCyc	MMAZ192952:MM0121-MON.
BRENDA	1.2.99.2. 261165.
Family and domain databases
InterPro	IPR016101. CO_DH_a-bundle. IPR010047. CO_DH_cat. IPR004137. Prismane. IPR016099. Prismane-like_a/b-sand. [Graphical view]
Gene3D	G3DSA:1.20.1270.30. CO_DH_a-bundle. 1 hit. G3DSA:3.40.50.2030. Prismane-like_a/b-sand. 1 hit.
Pfam	PF03063. Prismane. 1 hit. [Graphical view]
PIRSF	PIRSF005023. CODH. 1 hit.
TIGRFAMs	TIGR01702. CO_DH_cata. 1 hit.
ProtoNet	Search...

Entry information

Entry name

COOS1_METMA

Accession

Primary (citable) accession number: Q8Q0L5

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 31, 2003
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 48 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents