Q8Q037 (GLMM_METMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Probable phosphoglucosamine mutase
EC=5.4.2.10

Gene names

Name:	glmM
Ordered Locus Names:	MM_0301

Organism

Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

192952 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina mazei

Protein attributes

Sequence length	434 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate By similarity. HAMAP-Rule MF_01554
Catalytic activity	Alpha-D-glucosamine 1-phosphate = D-glucosamine 6-phosphate. HAMAP-Rule MF_01554
Cofactor	Binds 1 magnesium ion per subunit By similarity. HAMAP-Rule MF_01554
Post-translational modification	Activated by phosphorylation By similarity. HAMAP-Rule MF_01554
Sequence similarities	Belongs to the phosphohexose mutase family.
Sequence caution	The sequence AAM29997.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
PTM	Phosphoprotein
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	carbohydrate metabolic process Inferred from electronic annotation. Source: InterPro
Molecular_function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP phosphoglucosamine mutase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 434	434	Probable phosphoglucosamine mutase HAMAP-Rule MF_01554		PRO_0000337820
Sites
	Active site	91	1	Phosphoserine intermediate By similarity
	Metal binding	91	1	Magnesium; via phosphate group By similarity
	Metal binding	229	1	Magnesium By similarity
	Metal binding	231	1	Magnesium By similarity
	Metal binding	233	1	Magnesium By similarity
Amino acid modifications
	Modified residue	91	1	Phosphoserine By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8Q037 [UniParc]. Last modified June 10, 2008. Version 2. Checksum: 6B6C6857AAEFB508	FASTA	434	47,007
	10 20 30 40 50 60 MKLFGSSGIR GIVNTEVTPE LALKVGLVLG SRKKTAVIGR DPRVSAPMIE HALVAGLTAA 70 80 90 100 110 120 GCDVTKAGMV TTPTLAYAAR KYECGVMVTA SHNPSEYVGI KLWNPDGMAF DSAQQEEIEE 130 140 150 160 170 180 AIEKENFSRV TWDLIGKIAE DENAIRDHMD MIEGLVGKSK LRVVLDCGCG AGSTITPYLL 190 200 210 220 230 240 QELGCEIITL NSQPDGHFPA RNPEPNDQNL SLLKKAVVAF GADLGIAHDG DADRMMAVDE 250 260 270 280 290 300 KGNFVSGDEL LAIFGRFECG DKKGSVVVPV DTSLMVDDYL EGSEIIRTRV GDVYVAEGIK 310 320 330 340 350 360 QCKAIYGGEP SGSWIFPKIS YCPDGIYAAA KLVEIVNEKK LSELRAELPI YATKRGALPC 370 380 390 400 410 420 ANEKKAEFMK RAKSKLEPLG KVLDIDGIRV ELENGWVLVR PSGTEAKVRI TAEARENVDG 430 IYEMAEKIVK EALK

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008384 Genomic DNA. Translation: AAM29997.1. Different initiation.
RefSeq	NP_632325.1. NC_003901.1.
3D structure databases
ProteinModelPortal	Q8Q037.
ModBase	Search...
Protein-protein interaction databases
STRING	192952.MM_0301.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM29997; AAM29997; MM_0301.
GeneID	1478643.
KEGG	mma:MM_0301.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1109.
HOGENOM	HOG000268680.
KO	K03431.
OMA	NANGMAY.
ProtClustDB	CLSK811941.
Enzyme and pathway databases
BioCyc	MMAZ192952:GCK2-315-MONOMER.
Family and domain databases
Gene3D	3.40.120.10. 3 hits.
HAMAP	MF_01554_A. GlmM_A.
InterPro	IPR005844. A-D-PHexomutase_a/b/a-I. IPR016055. A-D-PHexomutase_a/b/a-I/II/III. IPR005845. A-D-PHexomutase_a/b/a-II. IPR005846. A-D-PHexomutase_a/b/a-III. IPR005843. A-D-PHexomutase_C. IPR016066. A-D-PHexomutase_CS. IPR005841. Alpha-D-phosphohexomutase_SF. IPR023666. GlmM_arc. IPR024086. GlmM_arc-related. [Graphical view]
Pfam	PF02878. PGM_PMM_I. 1 hit. PF02879. PGM_PMM_II. 1 hit. PF02880. PGM_PMM_III. 1 hit. PF00408. PGM_PMM_IV. 1 hit. [Graphical view]
PRINTS	PR00509. PGMPMM.
SUPFAM	SSF53738. A-D-PHexomutase_a/b/a-I/II/III. 3 hits.
TIGRFAMs	TIGR03990. Arch_GlmM. 1 hit.
PROSITE	PS00710. PGM_PMM. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

GLMM_METMA

Accession

Primary (citable) accession number: Q8Q037

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 10, 2008
Last sequence update:	June 10, 2008
Last modified:	May 29, 2013
This is version 60 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program