Skip Header

Contribute Send feedback
Read comments (?) or add your own

Q8PZZ7 (Q8PZZ7_METMA) Unreviewed, UniProtKB/TrEMBL

Last modified January 25, 2012. Version 55. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry infoCustomize order

Names and origin

Protein namesRecommended name:
Amidophosphoribosyltransferase PIRNR PIRNR000485
Short name=ATase PIRNR PIRNR000485
EC=2.4.2.14 PIRNR PIRNR000485
Alternative name(s):
Glutamine phosphoribosylpyrophosphate amidotransferase PIRNR PIRNR000485
Gene names
Ordered Locus Names:MM_0341
OrganismMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP] EMBL AAM30037.1
Taxonomic identifier192952 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length485 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O. PIRNR PIRNR000485

Cofactor

Binds 1 4Fe-4S cluster per subunit By similarity. PIRSR PIRSR000485-3

Binds 1 magnesium ion per subunit By similarity. PIRNR PIRNR000485

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 1/2. PIRNR PIRNR000485

Sequence similarities

In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. PIRNR PIRNR000485

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Sites

Active site51For GATase activity By similarity PIRSR PIRSR000485-1
Metal binding2461Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding3921Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4431Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3
Metal binding4461Iron-sulfur (4Fe-4S) By similarity PIRSR PIRSR000485-3

Sequences

Sequence LengthMass (Da)Tools
Q8PZZ7 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 552C055A61E30793

FASTA48553,117
        10         20         30         40         50         60 
MKEECGVAGI ILPDDRPASN AVAFKLYYAL YALQHRGQES TGIMVHNGSC PLSIKGMGLV 

        70         80         90        100        110        120 
PDVYNKDSLG RLVGNAGVGH VRYSTTGGSK IENCQPFILN FKGGTVAIAH NGNLVNAREL 

       130        140        150        160        170        180 
KDELENEGRI FISDSDTEVI GHLLVKELIK HEPIESIRTV MRKLVGSYSL VIFINGVIYA 

       190        200        210        220        230        240 
VRDPFGFKPL CFGEVDGGYG VFSESVAIDT LNGTLIRDVK PGEVMVFTGS GFESHQLANE 

       250        260        270        280        290        300 
PHPAHCVFEF IYFARPDSVI DGKLVYKVRE RIGRELAREH HVDADIVSPV PDSGITSAIG 

       310        320        330        340        350        360 
YARESGIMYL EGLMKNRYIG RTFILPGQDL RETAVRLKMN AIQDNIKGKR VVLVDDSIVR 

       370        380        390        400        410        420 
GTTSRRIIDM VRKAGASEVH ARVGSPAIIA PCYLGIDMAT RQELIASYKT IKEVEGLISA 

       430        440        450        460        470        480 
DSLGYLSIDG LMRALECDKN DMCIGCLTGE YPVEIPGEKC RKKQTRLDDF SKAERSSQAV 


SPDSL

« Hide

References

[1]"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. expand/collapse author list , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE008384 Genomic DNA. Translation: AAM30037.1.
RefSeqNP_632365.1. NC_003901.1.

3D structure databases

HSSPHSSP built from PDB template 1AO0 based on UniProtKB P00497.
ProteinModelPortalQ8PZZ7.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1478683.
GenomeReviewsGene locus MM_0341 in contig AE008384_GR.
KEGGmma:MM_0341.
NMPDRfig|192952.1.peg.341.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG392416.
OMAVWAPGEE.
PhylomeDBQ8PZZ7.
ProtClustDBCLSK811961.

Family and domain databases

InterProIPR005854. Amd_phspho_trans.
IPR000583. GATase_2.
IPR017932. GATase_II.
IPR000836. PRibTrfase.
[Graphical view]
KOK00764.
PANTHERPTHR11907. Amd_phspho_trans. 1 hit.
PfamPF00310. GATase_2. 1 hit.
PF00156. Pribosyltran. 1 hit.
[Graphical view]
PIRSFPIRSF000485. Amd_phspho_trans. 1 hit.
TIGRFAMsTIGR01134. PurF. 1 hit.
PROSITEPS51278. GATASE_TYPE_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8PZZ7_METMA
AccessionPrimary (citable) accession number: Q8PZZ7
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 55 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info