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Q8PZR8

- HISX_METMA

UniProt

Q8PZR8 - HISX_METMA

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Protein
Histidinol dehydrogenase
Gene
hisD, MM_0424
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine By similarity.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Binds 1 zinc ion per subunit By similarity.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei129 – 1291NAD By similarity
Binding sitei191 – 1911NAD By similarity
Binding sitei214 – 2141NAD By similarity
Binding sitei237 – 2371Substrate By similarity
Metal bindingi259 – 2591Zinc By similarity
Binding sitei259 – 2591Substrate By similarity
Metal bindingi262 – 2621Zinc By similarity
Binding sitei262 – 2621Substrate By similarity
Active sitei326 – 3261Proton acceptor By similarity
Active sitei327 – 3271Proton acceptor By similarity
Binding sitei327 – 3271Substrate By similarity
Metal bindingi360 – 3601Zinc By similarity
Binding sitei360 – 3601Substrate By similarity
Binding sitei414 – 4141Substrate By similarity
Metal bindingi419 – 4191Zinc By similarity
Binding sitei419 – 4191Substrate By similarity

GO - Molecular functioni

  1. NAD binding Source: InterPro
  2. histidinol dehydrogenase activity Source: UniProtKB-HAMAP
  3. zinc ion binding Source: UniProtKB-HAMAP

GO - Biological processi

  1. histidine biosynthetic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Amino-acid biosynthesis, Histidine biosynthesis

Keywords - Ligandi

Metal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-441-MONOMER.
UniPathwayiUPA00031; UER00014.

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenase (EC:1.1.1.23)
Short name:
HDH
Gene namesi
Name:hisD
Ordered Locus Names:MM_0424
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000000595: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 433433Histidinol dehydrogenaseUniRule annotation
PRO_0000135897Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_0424.

Structurei

3D structure databases

ProteinModelPortaliQ8PZR8.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0141.
HOGENOMiHOG000243914.
KOiK00013.
OMAiYAAKLCG.

Family and domain databases

HAMAPiMF_01024. HisD.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view]
PfamiPF00815. Histidinol_dh. 1 hit.
[Graphical view]
PIRSFiPIRSF000099. Histidinol_dh. 1 hit.
PRINTSiPR00083. HOLDHDRGNASE.
SUPFAMiSSF53720. SSF53720. 1 hit.
TIGRFAMsiTIGR00069. hisD. 1 hit.
PROSITEiPS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8PZR8-1 [UniParc]FASTAAdd to Basket

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MIIMLFKKLS DVSEAEMQRL ISRGSGLADV GDTVSAVLSD VRMKGDAALR    50
EYTKKFDKVE LANFEVSEEE FEKALSEIGS ELLGHLRIAA ENIRAFHRAQ 100
MPETTWFMEL QPGVVLGQKA TPLESVGAYA PGGRASYPST VLMTVIPARV 150
AGVEQVIVCT PPRADGSVHP LTLAAAKVAG ADKVFKLGGV QAIGAMAYGT 200
ETVPRVDKIV GPGNVFVTSA KMQVRDIAEI DFPAGPSEVL IIADESADAA 250
MAASDIIAQA EHDPNAVSVL VTTSETLAEE VEQEVLAQAE STARSEIVKI 300
SLENAAVLIA DSLDQCIDFS NKFAPEHLEI MVEDSDFVLD RIKNAGSIFI 350
GNYAPVPVGD YASGTNHVLP TAGYAKIYSG LNINHFLKYS SIQKISKSGL 400
ESLKETVIAL AEEEGLKAHA DSIRARFGYR PSK 433
Length:433
Mass (Da):46,324
Last modified:October 1, 2002 - v1
Checksum:iB0F7CE128B9D5B9D
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM30120.1.
RefSeqiNP_632448.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM30120; AAM30120; MM_0424.
GeneIDi1478766.
KEGGimma:MM_0424.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM30120.1 .
RefSeqi NP_632448.1. NC_003901.1.

3D structure databases

ProteinModelPortali Q8PZR8.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192952.MM_0424.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM30120 ; AAM30120 ; MM_0424 .
GeneIDi 1478766.
KEGGi mma:MM_0424.

Phylogenomic databases

eggNOGi COG0141.
HOGENOMi HOG000243914.
KOi K00013.
OMAi YAAKLCG.

Enzyme and pathway databases

UniPathwayi UPA00031 ; UER00014 .
BioCyci MMAZ192952:GCK2-441-MONOMER.

Family and domain databases

HAMAPi MF_01024. HisD.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR001692. Histidinol_DH_CS.
IPR022695. Histidinol_DH_monofunct.
IPR012131. Hstdl_DH.
[Graphical view ]
Pfami PF00815. Histidinol_dh. 1 hit.
[Graphical view ]
PIRSFi PIRSF000099. Histidinol_dh. 1 hit.
PRINTSi PR00083. HOLDHDRGNASE.
SUPFAMi SSF53720. SSF53720. 1 hit.
TIGRFAMsi TIGR00069. hisD. 1 hit.
PROSITEi PS00611. HISOL_DEHYDROGENASE. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
    Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
    , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Entry informationi

Entry nameiHISX_METMA
AccessioniPrimary (citable) accession number: Q8PZR8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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