Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Histidinol dehydrogenase

Gene

hisD

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.UniRule annotation

Catalytic activityi

L-histidinol + H2O + 2 NAD+ = L-histidine + 2 NADH.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: Binds 1 zinc ion per subunit.UniRule annotation

Pathwayi: L-histidine biosynthesis

This protein is involved in step 9 of the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate.UniRule annotation
Proteins known to be involved in the 9 steps of the subpathway in this organism are:
  1. ATP phosphoribosyltransferase (hisG)
  2. Phosphoribosyl-ATP pyrophosphatase (hisE)
  3. Phosphoribosyl-AMP cyclohydrolase (hisI)
  4. 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase (hisA)
  5. Imidazole glycerol phosphate synthase subunit HisF (hisF), Imidazole glycerol phosphate synthase subunit HisH (hisH)
  6. Imidazoleglycerol-phosphate dehydratase (hisB)
  7. Histidinol-phosphate aminotransferase (hisC)
  8. no protein annotated in this organism
  9. Histidinol dehydrogenase (hisD)
This subpathway is part of the pathway L-histidine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-histidine from 5-phospho-alpha-D-ribose 1-diphosphate, the pathway L-histidine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei129NADUniRule annotation1
Binding sitei191NADUniRule annotation1
Binding sitei214NADUniRule annotation1
Binding sitei237SubstrateUniRule annotation1
Metal bindingi259ZincUniRule annotation1
Binding sitei259SubstrateUniRule annotation1
Metal bindingi262ZincUniRule annotation1
Binding sitei262SubstrateUniRule annotation1
Active sitei326Proton acceptorUniRule annotation1
Active sitei327Proton acceptorUniRule annotation1
Binding sitei327SubstrateUniRule annotation1
Metal bindingi360ZincUniRule annotation1
Binding sitei360SubstrateUniRule annotation1
Binding sitei414SubstrateUniRule annotation1
Metal bindingi419ZincUniRule annotation1
Binding sitei419SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAmino-acid biosynthesis, Histidine biosynthesis
LigandMetal-binding, NAD, Zinc

Enzyme and pathway databases

BioCyciMMAZ192952:G1FZI-460-MONOMER
UniPathwayiUPA00031; UER00014

Names & Taxonomyi

Protein namesi
Recommended name:
Histidinol dehydrogenaseUniRule annotation (EC:1.1.1.23UniRule annotation)
Short name:
HDHUniRule annotation
Gene namesi
Name:hisDUniRule annotation
Ordered Locus Names:MM_0424
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001358971 – 433Histidinol dehydrogenaseAdd BLAST433

Proteomic databases

PRIDEiQ8PZR8

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_0424

Structurei

3D structure databases

ProteinModelPortaliQ8PZR8
SMRiQ8PZR8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the histidinol dehydrogenase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04352 Archaea
COG0141 LUCA
HOGENOMiHOG000243914
KOiK00013
OMAiQAEHDPM
OrthoDBiPOG093Z04GH

Family and domain databases

CDDicd06572 Histidinol_dh, 1 hit
HAMAPiMF_01024 HisD, 1 hit
InterProiView protein in InterPro
IPR016161 Ald_DH/histidinol_DH
IPR001692 Histidinol_DH_CS
IPR022695 Histidinol_DH_monofunct
IPR012131 Hstdl_DH
PANTHERiPTHR21256 PTHR21256, 1 hit
PfamiView protein in Pfam
PF00815 Histidinol_dh, 1 hit
PIRSFiPIRSF000099 Histidinol_dh, 1 hit
PRINTSiPR00083 HOLDHDRGNASE
SUPFAMiSSF53720 SSF53720, 1 hit
TIGRFAMsiTIGR00069 hisD, 1 hit
PROSITEiView protein in PROSITE
PS00611 HISOL_DEHYDROGENASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PZR8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIIMLFKKLS DVSEAEMQRL ISRGSGLADV GDTVSAVLSD VRMKGDAALR
60 70 80 90 100
EYTKKFDKVE LANFEVSEEE FEKALSEIGS ELLGHLRIAA ENIRAFHRAQ
110 120 130 140 150
MPETTWFMEL QPGVVLGQKA TPLESVGAYA PGGRASYPST VLMTVIPARV
160 170 180 190 200
AGVEQVIVCT PPRADGSVHP LTLAAAKVAG ADKVFKLGGV QAIGAMAYGT
210 220 230 240 250
ETVPRVDKIV GPGNVFVTSA KMQVRDIAEI DFPAGPSEVL IIADESADAA
260 270 280 290 300
MAASDIIAQA EHDPNAVSVL VTTSETLAEE VEQEVLAQAE STARSEIVKI
310 320 330 340 350
SLENAAVLIA DSLDQCIDFS NKFAPEHLEI MVEDSDFVLD RIKNAGSIFI
360 370 380 390 400
GNYAPVPVGD YASGTNHVLP TAGYAKIYSG LNINHFLKYS SIQKISKSGL
410 420 430
ESLKETVIAL AEEEGLKAHA DSIRARFGYR PSK
Length:433
Mass (Da):46,324
Last modified:October 1, 2002 - v1
Checksum:iB0F7CE128B9D5B9D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA Translation: AAM30120.1
RefSeqiWP_011032377.1, NC_003901.1

Genome annotation databases

EnsemblBacteriaiAAM30120; AAM30120; MM_0424
GeneIDi24877057
KEGGimma:MM_0424
PATRICifig|192952.21.peg.511

Similar proteinsi

Entry informationi

Entry nameiHISX_METMA
AccessioniPrimary (citable) accession number: Q8PZR8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Cookie policy

We would like to use anonymized google analytics cookies to gather statistics on how uniprot.org is used in aggregate. Learn more

UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health