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Protein

Phosphopantetheine adenylyltransferase

Gene

coaD

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate.UniRule annotation

Catalytic activityi

ATP + pantetheine 4'-phosphate = diphosphate + 3'-dephospho-CoA.UniRule annotation

Pathwayi: coenzyme A biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes CoA from (R)-pantothenate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. no protein annotated in this organism
  4. Phosphopantetheine adenylyltransferase (coaD)
  5. no protein annotated in this organism
This subpathway is part of the pathway coenzyme A biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes CoA from (R)-pantothenate, the pathway coenzyme A biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Nucleotidyltransferase, Transferase

Keywords - Biological processi

Coenzyme A biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphopantetheine adenylyltransferaseUniRule annotation (EC:2.7.7.3UniRule annotation)
Alternative name(s):
Dephospho-CoA pyrophosphorylaseUniRule annotation
Pantetheine-phosphate adenylyltransferaseUniRule annotation
Short name:
PPATUniRule annotation
Gene namesi
Name:coaDUniRule annotation
Ordered Locus Names:MM_0458
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001563221 – 154Phosphopantetheine adenylyltransferaseAdd BLAST154

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_0458.

Structurei

3D structure databases

ProteinModelPortaliQ8PZN4.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the eukaryotic CoaD family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01223. Archaea.
COG1019. LUCA.
HOGENOMiHOG000284155.
KOiK02201.
OMAiEIMVIND.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00647. PPAT_arch. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR023540. Ppantetheine_adenylTrfase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PZN4-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKVAVGGTF QYLHDGHARL IEKAFEIAGS GKVYIGLTSD EMLQKNHSVE
60 70 80 90 100
SYKIRRSRLL EYIKKMGVPE EKYEVTRLND PCGPTIEEDF DHIIVSPETY
110 120 130 140 150
PVALKINTIR EKKGKKPLEI VYVEYVMAED GIPISSTRIS KGEIDRHGRL

KKEA
Length:154
Mass (Da):17,504
Last modified:October 1, 2002 - v1
Checksum:iDA7E0715B51D429D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM30154.1.
RefSeqiWP_011032411.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM30154; AAM30154; MM_0458.
GeneIDi24880728.
KEGGimma:MM_0458.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM30154.1.
RefSeqiWP_011032411.1. NC_003901.1.

3D structure databases

ProteinModelPortaliQ8PZN4.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi192952.MM_0458.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM30154; AAM30154; MM_0458.
GeneIDi24880728.
KEGGimma:MM_0458.

Phylogenomic databases

eggNOGiarCOG01223. Archaea.
COG1019. LUCA.
HOGENOMiHOG000284155.
KOiK02201.
OMAiEIMVIND.

Enzyme and pathway databases

UniPathwayiUPA00241; UER00355.

Family and domain databases

Gene3Di3.40.50.620. 1 hit.
HAMAPiMF_00647. PPAT_arch. 1 hit.
InterProiIPR004821. Cyt_trans-like.
IPR023540. Ppantetheine_adenylTrfase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01467. CTP_transf_like. 1 hit.
[Graphical view]
TIGRFAMsiTIGR00125. cyt_tran_rel. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCOAD_METMA
AccessioniPrimary (citable) accession number: Q8PZN4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.