Q8PZA0 (IF2G_METMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Translation initiation factor 2 subunit gamma

Alternative name(s):
aIF2-gamma
eIF-2-gamma

Gene names

Name:	eif2g
Ordered Locus Names:	MM_0594

Organism

Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

192952 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina mazei

Protein attributes

Sequence length	431 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA By similarity. HAMAP-Rule MF_00119
Subunit structure	Heterotrimer composed of an alpha, a beta and a gamma chain By similarity.
Sequence similarities	Belongs to the GTP-binding elongation factor family. EIF2G subfamily.

Ontologies

Keywords
Biological process	Protein biosynthesis
Ligand	GTP-binding Nucleotide-binding
Molecular function	Initiation factor
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	GTP catabolic process Inferred from electronic annotation. Source: GOC translational elongation Inferred from electronic annotation. Source: GOC
Molecular_function	GTP binding Inferred from electronic annotation. Source: HAMAP GTPase activity Inferred from electronic annotation. Source: InterPro translation elongation factor activity Inferred from electronic annotation. Source: HAMAP translation initiation factor activity Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 431	431	Translation initiation factor 2 subunit gamma HAMAP-Rule MF_00119		PRO_0000137456
Regions
	Nucleotide binding	35 – 42	8	GTP By similarity
	Nucleotide binding	110 – 114	5	GTP By similarity
	Nucleotide binding	166 – 169	4	GTP By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8PZA0 [UniParc]. Last modified October 10, 2002. Version 1. Checksum: E774C98971C55508	FASTA	431	46,620
	10 20 30 40 50 60 MHRFRKNTCL ISDYFHSTGG NYNLSQPCVN IGMVGHVDHG KTTLVRALSG VWTDTHSEEV 70 80 90 100 110 120 KRGISIRLGY ADSPFMKCPK CPEPQCYTVE KTCPNCGEKT EEHRTVSFVD APGHETLMAT 130 140 150 160 170 180 MLSGAAIMDG AVLVIAANED CPQPQTKEHL MALDIIGIKN IVIVQNKIDL VSREKIIENY 190 200 210 220 230 240 HQIKEFVKGT VAENAPVIPI SAQQNINIDI LIDALETQIP TPSHKVDKPA SMLIARSFDI 250 260 270 280 290 300 NKPGASIEEI RGGVIGGTLT EGVLHPGDEL EIRPGIKVTT EGSTRWIPIL TTVSSIYAGA 310 320 330 340 350 360 TKVDEATPGG LLAVGTYLDP TLTKGDSLTG QMAGVPGTLP ETRHQFVMEL HLLDRVVGVT 370 380 390 400 410 420 REEKINEIKT SEPLMLNIGT ATTVGVVTSA RKNEAQVALK RPISAAIGAM VAISRRVDSR 430 WRLIGVGVIK S

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008384 Genomic DNA. Translation: AAM30290.1.
RefSeq	NP_632618.1. NC_003901.1.
3D structure databases
ProteinModelPortal	Q8PZA0.
SMR	Q8PZA0. Positions 25-430.
ModBase	Search...
Protein-protein interaction databases
STRING	192952.MM_0594.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM30290; AAM30290; MM_0594.
GeneID	1478936.
KEGG	mma:MM_0594.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG5257.
HOGENOM	HOG000229292.
KO	K03242.
OMA	IAANEPC.
ProtClustDB	PRK04000.
Family and domain databases
HAMAP	MF_00119. eIF-2-gamma.
InterPro	IPR000795. EF_GTP-bd_dom. IPR005225. Small_GTP-bd_dom. IPR022424. TIF2_gsu. IPR015256. TIF2_gsu_C. IPR009001. Transl_elong_EF1A/Init_IF2_C. IPR004161. Transl_elong_EFTu/EF1A_2. IPR009000. Transl_elong_init/rib_B-barrel. [Graphical view]
Pfam	PF09173. eIF2_C. 1 hit. PF00009. GTP_EFTU. 1 hit. PF03144. GTP_EFTU_D2. 1 hit. [Graphical view]
PRINTS	PR00315. ELONGATNFCT.
SUPFAM	SSF50465. Elong_init_C. 1 hit. SSF50447. Translat_factor. 1 hit.
TIGRFAMs	TIGR03680. eif2g_arch. 1 hit. TIGR00231. small_GTP. 1 hit.
ProtoNet	Search...

Entry information

Entry name

IF2G_METMA

Accession

Primary (citable) accession number: Q8PZA0

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 10, 2002
Last modified:	May 1, 2013
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program