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Protein

Putative adenylate kinase

Gene

MM_0625

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates.UniRule annotation

Catalytic activityi

ATP + AMP = 2 ADP.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei115 – 1151ATPUniRule annotation
Binding sitei119 – 1191ATPUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 156ATPUniRule annotation

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-641-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative adenylate kinaseUniRule annotation (EC:2.7.4.3UniRule annotation)
Short name:
AKUniRule annotation
Alternative name(s):
ATP-AMP transphosphorylaseUniRule annotation
Gene namesi
Ordered Locus Names:MM_0625
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 196196Putative adenylate kinasePRO_0000153908Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_0625.

Structurei

3D structure databases

ProteinModelPortaliQ8PZ69.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni30 – 5324NMPbindUniRule annotationAdd
BLAST
Regioni118 – 12811LIDUniRule annotationAdd
BLAST

Sequence similaritiesi

Belongs to the adenylate kinase family. AK6 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01038. Archaea.
COG1936. LUCA.
HOGENOMiHOG000224471.
KOiK18532.
OMAiVDWSEVY.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PZ69-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MLIGLTGTPG TGKTSVSKLL EKRRGWKVVY LNDLIKEEHL YSEVDEERDS
60 70 80 90 100
VIADMELIRE RLSGILEEEK GQHAEKAKVN GEEKENITII ESHLAHYITD
110 120 130 140 150
IVIVLRAYPP ELKKRLEKRG YSEEKINENA EAESIDLILA EAFEWCKKVF
160 170 180 190
EVNTTGRTAE ETLGDVEKII DYILAGKENE LQEYIPGSLD WIDSVP
Length:196
Mass (Da):22,343
Last modified:October 1, 2002 - v1
Checksum:i2BAAAE1DE6A26633
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM30321.1.
RefSeqiWP_011032576.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM30321; AAM30321; MM_0625.
GeneIDi24880571.
KEGGimma:MM_0625.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM30321.1.
RefSeqiWP_011032576.1. NC_003901.1.

3D structure databases

ProteinModelPortaliQ8PZ69.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi192952.MM_0625.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM30321; AAM30321; MM_0625.
GeneIDi24880571.
KEGGimma:MM_0625.

Phylogenomic databases

eggNOGiarCOG01038. Archaea.
COG1936. LUCA.
HOGENOMiHOG000224471.
KOiK18532.
OMAiVDWSEVY.

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-641-MONOMER.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
HAMAPiMF_00039. Adenylate_kinase_AK6. 1 hit.
InterProiIPR020618. Adenyl_kinase_AK6.
IPR027417. P-loop_NTPase.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiKAD6_METMA
AccessioniPrimary (citable) accession number: Q8PZ69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 13, 2004
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.