Reviewed, UniProtKB/Swiss-Prot Q8PZ68 (NADM_METMA)

Names and origin

Protein names

Recommended name:
    Nicotinamide-nucleotide adenylyltransferase
    EC=2.7.7.1
Alternative name(s):
    NAD(+) pyrophosphorylase
    NAD(+) diphosphorylase
    NMN adenylyltransferase

Gene names

Ordered Locus Names:

MM_0626

Organism

Methanosarcina mazei (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

2209 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	173 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	ATP + nicotinamide ribonucleotide = diphosphate + NAD+. HAMAP MF_00243
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; NAD(+) from nicotinamide ribonucleotide: step 1/1. HAMAP MF_00243
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the archaeal NMN adenylyltransferase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Ligand	ATP-binding NAD Nucleotide-binding
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW nicotinamide-nucleotide adenylyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 173	173	Nicotinamide-nucleotide adenylyltransferase HAMAP MF_00243		PRO_0000134993

Sequences

	Sequence		Length	Mass (Da)
	Q8PZ68-1 [UniParc]. Last modified August 30, 2005. Version 2. Checksum: D8D7EE0C6640B3D8	FASTA	173	19,970
	10 20 30 40 50 60 MTRAFYIGRF QPYHFGHHAV IARIAEEVDE LVIGIGSAQK SHEAIDPFTA GERVLMVYNA 70 80 90 100 110 120 LEHLSIRHYV VPIEDVRYNS IWVHHVVSRT PRFDVVYSNN PLVIQLFREA GFCVKESPLY 130 140 150 160 170 VRERYSGTEI RRRMIEGEKW EHLVPKPVAE VIKSFDGVSR LKNVSTSDSN FSL

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008384 Genomic DNA. Translation: AAM30322.1. Different initiation.
RefSeq	NP_632650.1.
3D structure databases
HSSP	HSSP built from PDB template 1F9A based on UniProtKB Q57961.
ModBase	Search...
Genome annotation databases
GeneID	1478968.
GenomeReviews	Gene locus MM_0626 in contig AE008384_GR.
KEGG	mma:MM_0626.
NMPDR	fig|192952.1.peg.626.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8PZ68.
Enzyme and pathway databases
BioCyc	MMAZ192952:MM0626-MON.
BRENDA	2.7.7.1. 261165.
Family and domain databases
HAMAP	MF_00243. [Tree]
InterPro	IPR004821. Cyt_trans_rel. IPR004820. Cytidylyltransf. IPR006418. NMN_Atrans_arc. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view]
Gene3D	G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit.
Pfam	PF01467. CTP_transf_2. 1 hit. [Graphical view]
TIGRFAMs	TIGR01527. arch_NMN_Atrans. 1 hit. TIGR00125. cyt_tran_rel. 1 hit.
ProtoNet	Search...

Entry information

Entry name

NADM_METMA

Accession

Primary (citable) accession number: Q8PZ68

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 9, 2003
Last sequence update:	August 30, 2005
Last modified:	June 16, 2009
This is version 41 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)