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Q8PZ66

- MER_METMA

UniProt

Q8PZ66 - MER_METMA

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Protein

5,10-methylenetetrahydromethanopterin reductase

Gene
mer, MM_0628
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the reversible reduction of methylene-H4MPT to methyl-H4MPT By similarity.UniRule annotation

Catalytic activityi

5-methyltetrahydromethanopterin + oxidized coenzyme F420 = 5,10-methylenetetrahydromethanopterin + reduced coenzyme F420.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. coenzyme F420-dependent N5,N10-methenyltetrahydromethanopterin reductase activity Source: UniProtKB-HAMAP
  2. oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen Source: InterPro

GO - Biological processi

  1. methanogenesis, from carbon dioxide Source: UniProtKB-UniPathway
  2. one-carbon metabolic process Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

Methanogenesis, One-carbon metabolism

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-644-MONOMER.
UniPathwayiUPA00640; UER00697.

Names & Taxonomyi

Protein namesi
Recommended name:
5,10-methylenetetrahydromethanopterin reductase (EC:1.5.98.2)
Alternative name(s):
Coenzyme F420-dependent N(5),N(10)-methylenetetrahydromethanopterin reductase
Methylene-H(4)MPT reductase
Gene namesi
Name:mer
Ordered Locus Names:MM_0628
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000000595: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 3283285,10-methylenetetrahydromethanopterin reductaseUniRule annotationPRO_0000084809Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_0628.

Structurei

3D structure databases

ProteinModelPortaliQ8PZ66.
SMRiQ8PZ66. Positions 1-327.

Family & Domainsi

Sequence similaritiesi

Belongs to the mer family.

Phylogenomic databases

eggNOGiCOG2141.
HOGENOMiHOG000223871.
KOiK00320.
OMAiIGPNKEK.

Family and domain databases

Gene3Di3.20.20.30. 1 hit.
HAMAPiMF_01091. F420_mer.
InterProiIPR011251. Luciferase-like_dom.
IPR019946. MeH4methanopterin_reductase.
[Graphical view]
PfamiPF00296. Bac_luciferase. 1 hit.
[Graphical view]
SUPFAMiSSF51679. SSF51679. 1 hit.
TIGRFAMsiTIGR03555. F420_mer. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PZ66-1 [UniParc]FASTAAdd to Basket

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MKFGIEFVPA DPALKIAYYA KLSEQQGFDY VWITDHYNNR DVYSTLTVLA    50
LNTNSIKIGS GVTNSYTRNP AITASSIASI AEISGGRAVL GLGPGDKATF 100
DAMGIAWEKP LATTKEAIQA IRDFIDGKKV SMDGEMVKFA GAKLAFKAGK 150
IPIYMGAQGP KMLELAGEVA DGVLINASHP KDFEVAVEQI RKGAEKVGRD 200
PSEVDVTAYA CFSIDKDPVK AVNAAKVVVA FIVAGSPDLV LERHGISVEA 250
KKQIGDAIAK GDFGSLMGGL VTPQMIEAFS ICGTPEDCMK RIKDLEAIGV 300
TQIVAGSPIG PDKEKAIKLI GKEIIAKM 328
Length:328
Mass (Da):34,812
Last modified:October 1, 2002 - v1
Checksum:iB5120CB00E004542
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM30324.1.
RefSeqiNP_632652.1. NC_003901.1.
WP_011032579.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM30324; AAM30324; MM_0628.
GeneIDi1478970.
KEGGimma:MM_0628.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM30324.1 .
RefSeqi NP_632652.1. NC_003901.1.
WP_011032579.1. NC_003901.1.

3D structure databases

ProteinModelPortali Q8PZ66.
SMRi Q8PZ66. Positions 1-327.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192952.MM_0628.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM30324 ; AAM30324 ; MM_0628 .
GeneIDi 1478970.
KEGGi mma:MM_0628.

Phylogenomic databases

eggNOGi COG2141.
HOGENOMi HOG000223871.
KOi K00320.
OMAi IGPNKEK.

Enzyme and pathway databases

UniPathwayi UPA00640 ; UER00697 .
BioCyci MMAZ192952:GCK2-644-MONOMER.

Family and domain databases

Gene3Di 3.20.20.30. 1 hit.
HAMAPi MF_01091. F420_mer.
InterProi IPR011251. Luciferase-like_dom.
IPR019946. MeH4methanopterin_reductase.
[Graphical view ]
Pfami PF00296. Bac_luciferase. 1 hit.
[Graphical view ]
SUPFAMi SSF51679. SSF51679. 1 hit.
TIGRFAMsi TIGR03555. F420_mer. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
    Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
    , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Entry informationi

Entry nameiMER_METMA
AccessioniPrimary (citable) accession number: Q8PZ66
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2003
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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