Reviewed,
UniProtKB/Swiss-Prot Q8PY83 (HDRB_METMA)
Last modified
July 13, 2010.
Version 46.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and originHide
| Protein names | Recommended name: CoB--CoM heterodisulfide reductase 1 subunit B EC=1.8.98.1 | ||||
| Gene names |
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| Organism | Methanosarcina mazei (Methanosarcina frisia) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 2209 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina |
Protein attributesHide
| Sequence length | 300 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology. |
General annotation (Comments)Hide
| Function | Part of a complex that catalyzes the reversible reduction of CoM-S-S-CoB to the thiol-coenzymes H-S-CoM (coenzyme M) and H-S-CoB (coenzyme B). HdrB may have a function in energy transduction By similarity. |
| Catalytic activity | Coenzyme B + coenzyme M + methanophenazine = N-(7-((2-sulfoethyl)dithio)heptanoyl)-O(3)-phospho-L-threonine + dihydromethanophenazine. |
| Pathway | |
| Subunit structure | The heterodisulfide reductase 1 is composed of three subunits; hdrA, hdrB and hdrC By similarity. |
| Sequence similarities | Belongs to the hdrB family. |
| Sequence caution | The sequence AAM30676.1 differs from that shown. Reason: Erroneous initiation. |
OntologiesHide
| Keywords | |
|---|---|
| Biological process | Methanogenesis |
| Molecular function | Oxidoreductase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cofactor metabolic process Inferred from electronic annotation. Source: InterPro methanogenesisInferred from electronic annotation. Source: UniProtKB-KW oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | CoB--CoM heterodisulfide reductase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)Hide
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||
Molecule processing | |||||||
|---|---|---|---|---|---|---|---|
| Chain | 1 – 300 | 300 | CoB--CoM heterodisulfide reductase 1 subunit B | PRO_0000150068 | |||
SequencesHide
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ReferencesHide
| [1] | "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. Gottschalk G.J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88. |
Cross-referencesHide
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE008384 Genomic DNA. Translation: AAM30676.1. Different initiation. |
| RefSeq | NP_633004.1. |
3D structure databases | |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1479322. |
| GenomeReviews | Gene locus MM_0980 in contig AE008384_GR. |
| KEGG | mma:MM_0980. |
| NMPDR | fig|192952.1.peg.980. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG513215. |
| OMA | HYGCHFL. |
| ProtClustDB | CLSK876313. |
Enzyme and pathway databases | |
| BioCyc | MMAZ192952:MM0980-MONOMER. |
| BRENDA | 1.8.98.1. 261165. |
Family and domain databases | |
| InterPro | IPR017678. CoB/CoM_hetero-S_Rdtase_bsu. IPR004017. Cys_rich_dom. [Graphical view] |
| Pfam | PF02754. CCG. 2 hits. [Graphical view] |
| TIGRFAMs | TIGR03288. CoB_CoM_SS_B. 1 hit. |
| ProtoNet | Search... |
Entry informationHide
| Entry name | HDRB_METMA | ||||||||
| Accession | Primary (citable) accession number: Q8PY83 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documentsHide
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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