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Protein

GMP synthase [glutamine-hydrolyzing] subunit B

Gene

guaAB

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of GMP from XMP.By similarity

Catalytic activityi

ATP + XMP + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate.

Pathwayi: GMP biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes GMP from XMP (L-Gln route).
Proteins known to be involved in this subpathway in this organism are:
  1. GMP synthase [glutamine-hydrolyzing] subunit B (guaAB), GMP synthase [glutamine-hydrolyzing] subunit A (guaAA)
This subpathway is part of the pathway GMP biosynthesis, which is itself part of Purine metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes GMP from XMP (L-Gln route), the pathway GMP biosynthesis and in Purine metabolism.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi29 – 35ATPBy similarity7

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase
Biological processGMP biosynthesis, Purine biosynthesis
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

UniPathwayiUPA00189; UER00296

Names & Taxonomyi

Protein namesi
Recommended name:
GMP synthase [glutamine-hydrolyzing] subunit B (EC:6.3.5.2)
Alternative name(s):
GMP synthetase
Gene namesi
Name:guaAB
Ordered Locus Names:MM_1218
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001402431 – 305GMP synthase [glutamine-hydrolyzing] subunit BAdd BLAST305

Proteomic databases

PRIDEiQ8PXK0

Interactioni

Subunit structurei

Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B).Curated

Protein-protein interaction databases

STRINGi192952.MM_1218

Structurei

3D structure databases

ProteinModelPortaliQ8PXK0
SMRiQ8PXK0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini2 – 184GMPS ATP-PPaseAdd BLAST183

Phylogenomic databases

eggNOGiarCOG00085 Archaea
COG0519 LUCA
HOGENOMiHOG000223964
KOiK01951
OMAiEGGIKSH
OrthoDBiPOG093Z04V2

Family and domain databases

CDDicd01997 GMP_synthase_C, 1 hit
Gene3Di3.40.50.620, 1 hit
HAMAPiMF_00345 GMP_synthase_B, 1 hit
InterProiView protein in InterPro
IPR001674 GMP_synth_C
IPR026598 GMP_synthase_B
IPR025777 GMPS_ATP_PPase_dom
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00958 GMP_synt_C, 1 hit
TIGRFAMsiTIGR00884 guaA_Cterm, 1 hit
PROSITEiView protein in PROSITE
PS51553 GMPS_ATP_PPASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PXK0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKPEKFIPK AIEKISKEIK DGKAIIALSG GVDSSVCAEL AYRAIGDRLQ
60 70 80 90 100
PIYIDTGLMR KGETERIRHI FSHMNLDVVY AKDRFLAALA GVTDPEEKRK
110 120 130 140 150
AIGETFIRVF EEEARKLAAD YLIQGTIYPD RIESEGGIKS HHNVGGLPSV
160 170 180 190 200
MDFKKIVEPI EDLYKDEVRE VAWALQLPDE ICERMPFPGP GLAVRVLGEV
210 220 230 240 250
TEEKLEVARE ANFIVEEELL ERFCPWQTFA AVLGKGTGVK GDVRAYGWIV
260 270 280 290 300
AIRAVGSRDG MTAEALELPW EVLKHLESRI TSEIPKVARV VYDITPKPPA

TIEFE
Length:305
Mass (Da):34,117
Last modified:October 1, 2002 - v1
Checksum:i61BE50537935988D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA Translation: AAM30914.1
RefSeqiWP_011033167.1, NC_003901.1

Genome annotation databases

EnsemblBacteriaiAAM30914; AAM30914; MM_1218
GeneIDi24879958
KEGGimma:MM_1218
PATRICifig|192952.21.peg.1423

Similar proteinsi

Entry informationi

Entry nameiGUAAB_METMA
AccessioniPrimary (citable) accession number: Q8PXK0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 1, 2004
Last sequence update: October 1, 2002
Last modified: June 20, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

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