Q8PXJ6 (MPTA_METMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
GTP cyclohydrolase MptA
EC=3.5.4.n2

Gene names

Name:	mptA
Ordered Locus Names:	MM_1222

Organism

Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

192952 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina mazei

Protein attributes

Sequence length	318 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Converts GTP to 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate, the first intermediate in the biosynthesis of coenzyme methanopterin By similarity. HAMAP-Rule MF_01527
Catalytic activity	GTP + H2O = formate + 7,8-dihydro-D-neopterin 2',3'-cyclic phosphate + diphosphate. HAMAP-Rule MF_01527
Cofactor	Binds 1 Fe2+ ion per subunit By similarity.
Pathway	Cofactor biosynthesis; 5,6,7,8-tetrahydromethanopterin biosynthesis. HAMAP-Rule MF_01527
Subunit structure	Homodimer By similarity.
Sequence similarities	Belongs to the GTP cyclohydrolase IV family.

Ontologies

Keywords
Ligand	Iron Metal-binding
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular_function	GTP cyclohydrolase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 318	318	GTP cyclohydrolase MptA HAMAP-Rule MF_01527		PRO_0000147745
Sites
	Site	167	1	May be catalytically important By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8PXJ6 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 100048EEE1711CC6	FASTA	318	35,746
	10 20 30 40 50 60 MEKCTFNLPD VQASKPSIAI NLTRVGVTNM KKLVEIKRKD KRPIVLISTF DVFVDLPSDR 70 80 90 100 110 120 KGANLSRNFE AVDEVLEKVL STPVYEIEQL CSDIAHNLLG RHEYANQAEV RMKSEYMIRR 130 140 150 160 170 180 ASPSTGIKCQ EVVNIFAEAS AVRGNGDRDY FDVKKLIGAE VVGMTACPCA QEIMRDKAAT 190 200 210 220 230 240 ELANLGVERD KIIKFLEKVP MATHNQRGRG IISIKVAHDF DVSLESIIKI IERSMSSSVY 250 260 270 280 290 300 EVLKRSDEKV VVETAHMNPK FVEDCVRAMA DNVVKEFPNL PDNAVITIKQ TNEESIHRHN 310 AFAERVALMG ELRKEISQ

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008384 Genomic DNA. Translation: AAM30918.1.
RefSeq	NP_633246.1. NC_003901.1.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	192952.MM_1222.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM30918; AAM30918; MM_1222.
GeneID	1479564.
KEGG	mma:MM_1222.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG1469.
HOGENOM	HOG000280680.
KO	K09007.
OMA	VEDCVRE.
ProtClustDB	PRK13675.
Enzyme and pathway databases
UniPathway	UPA00065.
Family and domain databases
Gene3D	3.10.270.10. 1 hit.
HAMAP	MF_01527_A. GTP_cyclohydrol_A.
InterPro	IPR003801. GTP_cyclohydrolase_FolE2/MptA. IPR022840. GTP_cyclohydrolase_MptA. IPR002042. Uricase. [Graphical view]
Pfam	PF02649. GCHY-1. 1 hit. [Graphical view]
TIGRFAMs	TIGR00294. TIGR00294. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MPTA_METMA

Accession

Primary (citable) accession number: Q8PXJ6

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 59 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program