Q8PXE7 (AROD_METMA) Reviewed, UniProtKB/Swiss-Prot
Last modified
December 14, 2011.
Version 59.
History...
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize orderNames and origin
| Protein names | Recommended name: 3-dehydroquinate dehydratase Short name=3-dehydroquinase EC=4.2.1.10 Alternative name(s): Type I DHQase | ||||
| Gene names |
| ||||
| Organism | Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP] | ||||
| Taxonomic identifier | 192952 [NCBI] | ||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina |
Protein attributes
| Sequence length | 242 AA. |
| Sequence status | Complete. |
| Protein existence | Inferred from homology |
General annotation (Comments)
| Catalytic activity | 3-dehydroquinate = 3-dehydroshikimate + H2O. HAMAP MF_00214 |
| Pathway | Metabolic intermediate biosynthesis; chorismate biosynthesis; chorismate from D-erythrose 4-phosphate and phosphoenolpyruvate: step 3/7. HAMAP MF_00214 |
| Sequence similarities | Belongs to the type-I 3-dehydroquinase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Amino-acid biosynthesis Aromatic amino acid biosynthesis |
| Ligand | Schiff base |
| Molecular function | Lyase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | aromatic amino acid family biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW |
| Molecular function | 3-dehydroquinate dehydratase activity Inferred from electronic annotation. Source: EC |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 242 | 242 | 3-dehydroquinate dehydratase HAMAP MF_00214 | PRO_0000138831 | |||||
Sites | |||||||||
| Active site | 135 | 1 | Proton acceptor By similarity | ||||||
| Active site | 162 | 1 | Schiff-base intermediate with substrate By similarity | ||||||
Sequences
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References
| [1] | "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. Gottschalk G.J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AE008384 Genomic DNA. Translation: AAM30969.1. |
| RefSeq | NP_633297.1. NC_003901.1. |
3D structure databases | |
| ProteinModelPortal | Q8PXE7. |
| ModBase | Search... |
Protocols and materials databases | |
| StructuralBiologyKnowledgebase | Search... |
Genome annotation databases | |
| GeneID | 1479615. |
| GenomeReviews | Gene locus MM_1273 in contig AE008384_GR. |
| KEGG | mma:MM_1273. |
| NMPDR | fig|192952.1.peg.1273. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | HBG732926. |
| OMA | VARRTVI. |
| PhylomeDB | Q8PXE7. |
| ProtClustDB | CLSK450616. |
Enzyme and pathway databases | |
| BioCyc | MMAZ192952:MM1273-MONOMER. |
Family and domain databases | |
| HAMAP | MF_00214. AroD. [Tree] |
| InterPro | IPR013785. Aldolase_TIM. IPR001381. DHquinase_I. [Graphical view] |
| Gene3D | G3DSA:3.20.20.70. Aldolase_TIM. 1 hit. |
| KO | K03785. |
| Pfam | PF01487. DHquinase_I. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR01093. AroD. 1 hit. |
| PROSITE | PS01028. DEHYDROQUINASE_I. False negative. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | AROD_METMA | ||||||||
| Accession | Primary (citable) accession number: Q8PXE7 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation program | Prokaryotic Protein Annotation Program | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

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