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Reviewed, UniProtKB/Swiss-Prot Q8PXE7 (AROD_METMA)

Last modified November 3, 2009. Version 46. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    3-dehydroquinate dehydratase
      Short name=3-dehydroquinase
    EC=4.2.1.10
Alternative name(s):
    Type I DHQase
Gene names
Name: aroD
Ordered Locus Names: MM_1273
OrganismMethanosarcina mazei (Methanosarcina frisia) [Complete proteome] [HAMAP]
Taxonomic identifier2209 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length242 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceInferred from homology.

General annotation (Comments)

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Aromatic amino acid biosynthesis
   LigandSchiff base
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processaromatic amino acid family biosynthetic process

Inferred from electronic annotation. Source: HAMAP

   Molecular function3-dehydroquinate dehydratase activity

Inferred from electronic annotation. Source: HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 2422423-dehydroquinate dehydratase HAMAP MF_00214
PRO_0000138831

Sites

Active site1351Proton acceptor By similarity
Active site1621Schiff-base intermediate with substrate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PXE7-1 [UniParc].

Last modified October 10, 2002. Version 1.
Checksum: 408AA002C92274B6

FASTA24226,152
        10         20         30         40         50         60 
MTQIGSFDLE KKTAVVAVIL EKPLENSKKA AEKGADILEI RLDLLGIRTP ERAAEVIREI 

        70         80         90        100        110        120 
KAETGIPIIV TSRSGAEGGK WDGKEEDRTG LLINLLSLKD GPDAIDIELS AGMKERNRVI 

       130        140        150        160        170        180 
KAAKDRETAV IVSSHDFLKT PPLQNMRTII EEMFLAGADI AKLAVMPLSV GDTLNLLRVT 

       190        200        210        220        230        240 
LDFKDAGKSV CTIAMGSQGK HTRVVAPFYG SVLTYASIES NASAAPGQLP VDEVKKIMEM 


LK 

« Hide

References

[1]"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. expand/collapse author list , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88.

Cross-references

Sequence databases

AE008384 Genomic DNA. Translation: AAM30969.1.
RefSeqNP_633297.1.

3D structure databases

HSSPHSSP built from PDB template 1L9W based on UniProtKB P24670.
ModBaseSearch...

Genome annotation databases

GeneID1479615.
GenomeReviewsGene locus MM_1273 in contig AE008384_GR.
KEGGmma:MM_1273.
NMPDRfig|192952.1.peg.1273.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMQ8PXE7.
OMAIAKLAVM.

Enzyme and pathway databases

BioCycMMAZ192952:MM1273-MON.
BRENDA4.2.1.10. 261165.

Family and domain databases

HAMAPMF_00214.
[Tree]
InterProIPR018508. 3-dehydroquinate_DH_AS.
IPR013785. Aldolase_TIM.
IPR001381. DHquinase_I.
[Graphical view]
Gene3DG3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
PfamPF01487. DHquinase_I. 1 hit.
[Graphical view]
ProDomPD005337. DHquinase_I. 1 hit.
[Graphical view] [Entries sharing at least one domain]
TIGRFAMsTIGR01093. aroD. 1 hit.
PROSITEPS01028. DEHYDROQUINASE_I. False negative.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameAROD_METMA
AccessionPrimary (citable) accession number: Q8PXE7
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 3, 2009
This is version 46 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)

Relevant documents

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents