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Protein

Chemotaxis response regulator protein-glutamate methylesterase of group 2 operon

Gene

cheB

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Involved in the modulation of the chemotaxis system; catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins) by CheR.UniRule annotation

Catalytic activityi

Protein L-glutamate O5-methyl ester + H2O = protein L-glutamate + methanol.UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Active sitei184UniRule annotation1
Active sitei211UniRule annotation1
Active sitei311UniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processChemotaxis

Names & Taxonomyi

Protein namesi
Recommended name:
Chemotaxis response regulator protein-glutamate methylesterase of group 2 operonUniRule annotation (EC:3.1.1.61UniRule annotation)
Gene namesi
Name:cheBUniRule annotation
Ordered Locus Names:MM_1326
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001580541 – 367Chemotaxis response regulator protein-glutamate methylesterase of group 2 operonAdd BLAST367

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei664-aspartylphosphateUniRule annotation1

Post-translational modificationi

Phosphorylated by CheA. Phosphorylation suppresses the inhibitory activity of the N-terminal domain.UniRule annotation

Keywords - PTMi

Phosphoprotein

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_1326.

Structurei

3D structure databases

ProteinModelPortaliQ8PX96.
SMRiQ8PX96.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini15 – 132Response regulatoryPROSITE-ProRule annotationAdd BLAST118
Domaini172 – 367CheB-type methylesteraseUniRule annotationAdd BLAST196

Domaini

The N-terminal regulatory domain inhibits the activity of the C-terminal effector domain.UniRule annotation

Phylogenomic databases

eggNOGiarCOG02382. Archaea.
COG2201. LUCA.
HOGENOMiHOG000151423.
KOiK03412.
OMAiYGMPMAV.
OrthoDBiPOG093Z00HE.

Family and domain databases

CDDicd16432. CheB_Rec. 1 hit.
cd00156. REC. 1 hit.
Gene3Di3.40.50.180. 1 hit.
HAMAPiMF_00099. CheB_methylest. 1 hit.
InterProiView protein in InterPro
IPR035909. CheB_C.
IPR011006. CheY-like_superfamily.
IPR008248. Sig_transdc_resp-reg_CheB.
IPR000673. Sig_transdc_resp-reg_Me-estase.
IPR001789. Sig_transdc_resp-reg_receiver.
PfamiView protein in Pfam
PF01339. CheB_methylest. 1 hit.
PF00072. Response_reg. 1 hit.
PIRSFiPIRSF000876. RR_chemtxs_CheB. 1 hit.
SMARTiView protein in SMART
SM00448. REC. 1 hit.
SUPFAMiSSF52172. SSF52172. 1 hit.
SSF52738. SSF52738. 1 hit.
PROSITEiView protein in PROSITE
PS50122. CHEB. 1 hit.
PS50110. RESPONSE_REGULATORY. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PX96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSNQHPKKVL EMVIRALIVD DSALIRKVLS DILNQDPKIA VIGTAINGED
60 70 80 90 100
GLEKVRKLKP DVVLLDNIMP VLDGLKTLSH IMEEFPTPVV IVSALGEKAE
110 120 130 140 150
EITLTALEYG AVDVIEKPSG ILSQSMHEMA EEICAKVRAV SKADLNNLGC
160 170 180 190 200
IRDLEHQIPE NHRKKKNSLR EKTSVRNVLA IGASTGGPRA LEKLIGSFPA
210 220 230 240 250
EIPAAVLIVQ HMPPGFTASL SKRLDAKSAL RVKEAQEGDI MEEGTVFIAP
260 270 280 290 300
GDYHMEIVRN KVNGFGEDTV HLSCGPKELG SRPSVNVLFR SVARIYGPRV
310 320 330 340 350
ISLVLTGMNC DGADGAEEIK KMGGKVIAED QSSCVIYGMP GEIVRRNLAD
360
FVLPLDKMAD EIVKIVR
Length:367
Mass (Da):39,888
Last modified:October 1, 2002 - v1
Checksum:iA7C706F4DD55695A
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31022.1.

Genome annotation databases

EnsemblBacteriaiAAM31022; AAM31022; MM_1326.
KEGGimma:MM_1326.
PATRICifig|192952.21.peg.1540.

Similar proteinsi

Entry informationi

Entry nameiCHEB2_METMA
AccessioniPrimary (citable) accession number: Q8PX96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome