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Protein

Arginine--tRNA ligase

Gene

argS

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg).

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Arginine--tRNA ligase (EC:6.1.1.19)
Alternative name(s):
Arginyl-tRNA synthetase
Short name:
ArgRS
Gene namesi
Name:argS
Ordered Locus Names:MM_1348
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001516481 – 569Arginine--tRNA ligaseAdd BLAST569

Proteomic databases

PRIDEiQ8PX74.

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_1348.

Structurei

3D structure databases

ProteinModelPortaliQ8PX74.
SMRiQ8PX74.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi123 – 133"HIGH" regionAdd BLAST11

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.

Phylogenomic databases

eggNOGiarCOG00487. Archaea.
COG0018. LUCA.
HOGENOMiHOG000247213.
KOiK01887.
OMAiNKPLHLG.
OrthoDBiPOG093Z013U.

Family and domain databases

CDDicd00671. ArgRS_core. 1 hit.
Gene3Di3.30.1360.70. 1 hit.
3.40.50.620. 1 hit.
HAMAPiMF_00123. Arg_tRNA_synth. 1 hit.
InterProiView protein in InterPro
IPR001412. aa-tRNA-synth_I_CS.
IPR001278. Arg-tRNA-ligase.
IPR005148. Arg-tRNA-synth_N.
IPR036695. Arg-tRNA-synth_N_sf.
IPR035684. ArgRS_core.
IPR008909. DALR_anticod-bd.
IPR014729. Rossmann-like_a/b/a_fold.
IPR009080. tRNAsynth_Ia_anticodon-bd.
PANTHERiPTHR11956. PTHR11956. 1 hit.
PfamiView protein in Pfam
PF03485. Arg_tRNA_synt_N. 1 hit.
PF05746. DALR_1. 1 hit.
PF00750. tRNA-synt_1d. 1 hit.
PRINTSiPR01038. TRNASYNTHARG.
SMARTiView protein in SMART
SM01016. Arg_tRNA_synt_N. 1 hit.
SM00836. DALR_1. 1 hit.
SUPFAMiSSF47323. SSF47323. 1 hit.
SSF55190. SSF55190. 1 hit.
TIGRFAMsiTIGR00456. argS. 1 hit.
PROSITEiView protein in PROSITE
PS00178. AA_TRNA_LIGASE_I. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PX74-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFLELKAQAT SILKEAIRKA GFEVEDSELQ FETSPHADLA SRAAFRLAGI
60 70 80 90 100
HRQNPKDLAS RIVSAVEIPE GSFIGKVSAA GPYINFFAGK HYLNGTVNAV
110 120 130 140 150
LKEKEKFGCG APKDRILLEH TSANPNGPLH VGHIRNSIIG DTLARILRRA
160 170 180 190 200
GYDVEVQYYV NDMGRQIAVV SWACERFELD LSRKSDSAIA DVYIKANVEL
210 220 230 240 250
DKNPGYIKEI DALMEKVEAG DVRTIEHFDK AVSLAVAGIK ETLLRLNVAH
260 270 280 290 300
DKFVSESTFL KSGAVHDIVE RIKATGRTKT DKGALVVDLS DYGFEKTLVI
310 320 330 340 350
QRSNGTSLYT TRDLAYHEWK AGQADRIIDV FGADHKLISG QLRATLNAIG
360 370 380 390 400
VKEPEVVIFE FVSLPEGSMS TRRGQFISAD DLFDRVTGAA FEQVETRRPE
410 420 430 440 450
TSYEFKKQVA EAVGLGAVRY DIVRVSPEKS TVFNWKEALD FEKQGAPYIQ
460 470 480 490 500
YSHARACSIL EKAKEEAAWN PDKEIDPSLL VEDSEIDLIK KMAMFDSVID
510 520 530 540 550
LGARELKPHV LAIYARELAD AFNQFYRFVP VIAAEDENVR AARLALVDCA
560
RVVLANSLDT LGIIAPESM
Length:569
Mass (Da):63,055
Last modified:October 10, 2002 - v1
Checksum:iD7D56C7A9800FB86
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31044.1.
RefSeqiWP_011033294.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM31044; AAM31044; MM_1348.
GeneIDi24879662.
KEGGimma:MM_1348.
PATRICifig|192952.21.peg.1562.

Similar proteinsi

Entry informationi

Entry nameiSYR_METMA
AccessioniPrimary (citable) accession number: Q8PX74
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: November 22, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families