Reviewed, UniProtKB/Swiss-Prot Q8PX04 (APGM_METMA)

Names and origin

Protein names

Recommended name:
    2,3-bisphosphoglycerate-independent phosphoglycerate mutase
      Short name=Phosphoglyceromutase
      Short name=BPG-independent PGAM
      Short name=aPGAM
    EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	MM_1418

Organism

Methanosarcina mazei (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

2209 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity.
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP MF_01402
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP MF_01402
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycolysis Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP MF_01402		PRO_0000138137

Sequences

	Sequence		Length	Mass (Da)
	Q8PX04-1 [UniParc]. Last modified October 10, 2002. Version 1. Checksum: FFB8BC932E9E15EC	FASTA	397	43,175
	10 20 30 40 50 60 MKYAILIGDG MADYPIEKLG NRTILQAART PAMDSIAARG RAGLAKTVPD SFPPGSDVAN 70 80 90 100 110 120 MSILGYDPAT YYSGRAPLEA ASMGVALAAD DVAFRCNLIT TEHGMIKDYS AGHISSDEAE 130 140 150 160 170 180 ILIDTLDYEL STENIRFYPG ISYRHLIVAG NNLGAETECT PPHDITGEKI DKYLPRGKDG 190 200 210 220 230 240 EFFSELIEAS KVVLELHPVN LKRVEEGKNP ANSIWVWGQG YAPKFTAFMK LYGKKGAVIS 250 260 270 280 290 300 AVDLLKGIGI YAGLDVIEVH GATGYLDTNY EGKVRAAIEA LKTRDLVFVH VEAPDEAGHE 310 320 330 340 350 360 GSIEKKLKAV EDFDSRIVAP ILEYAENSDE PFTILVLPDH PTPISVKTHT RDPIPFAIYR 370 380 390 TDKPETDNVE AFDEESVKNG SMGLVKASDL IGILIKS

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008384 Genomic DNA. Translation: AAM31114.1. Different initiation.
RefSeq	NP_633442.2.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1479760.
GenomeReviews	Gene locus MM_1418 in contig AE008384_GR.
KEGG	mma:MM_1418.
NMPDR	fig|192952.1.peg.1418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8PX04.
Enzyme and pathway databases
BioCyc	MMAZ192952:MM1418-MON.
BRENDA	5.4.2.1. 261165.
Family and domain databases
HAMAP	MF_01402. [Tree]
InterPro	IPR004456. APGAM_arc. IPR019304. bisP-indep_Pglycerate_Mutase. IPR013371. Homoserine_kin_put. IPR006124. Metalloenzyme. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
ProDom	PD004704. APGAM_DeoB. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR00306. apgM. 1 hit. TIGR02535. hyp_Hser_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_METMA

Accession

Primary (citable) accession number: Q8PX04

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 10, 2002
Last modified:	June 16, 2009
This is version 44 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)