Q8PX04 (APGM_METMA) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
2,3-bisphosphoglycerate-independent phosphoglycerate mutase
Short name=BPG-independent PGAM
Short name=Phosphoglyceromutase
Short name=aPGAM
EC=5.4.2.1

Gene names

Name:	apgM
Ordered Locus Names:	MM_1418

Organism

Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

192952 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina mazei

Protein attributes

Sequence length	397 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate By similarity. HAMAP-Rule MF_01402_A
Catalytic activity	2-phospho-D-glycerate = 3-phospho-D-glycerate. HAMAP-Rule MF_01402_A
Pathway	Carbohydrate degradation; glycolysis; pyruvate from D-glyceraldehyde 3-phosphate: step 3/5. HAMAP-Rule MF_01402_A
Sequence similarities	Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.
Sequence caution	The sequence AAM31114.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Glycolysis
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological_process	glycolysis Inferred from electronic annotation. Source: UniProtKB-UniPathway
Molecular_function	2,3-bisphosphoglycerate-independent phosphoglycerate mutase activity Inferred from electronic annotation. Source: HAMAP metal ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 397	397	2,3-bisphosphoglycerate-independent phosphoglycerate mutase HAMAP-Rule MF_01402_A		PRO_0000138137

Sequences

	Sequence		Length	Mass (Da)
	Q8PX04 [UniParc]. Last modified October 10, 2002. Version 1. Checksum: FFB8BC932E9E15EC	FASTA	397	43,175
	10 20 30 40 50 60 MKYAILIGDG MADYPIEKLG NRTILQAART PAMDSIAARG RAGLAKTVPD SFPPGSDVAN 70 80 90 100 110 120 MSILGYDPAT YYSGRAPLEA ASMGVALAAD DVAFRCNLIT TEHGMIKDYS AGHISSDEAE 130 140 150 160 170 180 ILIDTLDYEL STENIRFYPG ISYRHLIVAG NNLGAETECT PPHDITGEKI DKYLPRGKDG 190 200 210 220 230 240 EFFSELIEAS KVVLELHPVN LKRVEEGKNP ANSIWVWGQG YAPKFTAFMK LYGKKGAVIS 250 260 270 280 290 300 AVDLLKGIGI YAGLDVIEVH GATGYLDTNY EGKVRAAIEA LKTRDLVFVH VEAPDEAGHE 310 320 330 340 350 360 GSIEKKLKAV EDFDSRIVAP ILEYAENSDE PFTILVLPDH PTPISVKTHT RDPIPFAIYR 370 380 390 TDKPETDNVE AFDEESVKNG SMGLVKASDL IGILIKS

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008384 Genomic DNA. Translation: AAM31114.1. Different initiation.
RefSeq	NP_633442.2. NC_003901.1.
3D structure databases
ProteinModelPortal	Q8PX04.
ModBase	Search...
Protein-protein interaction databases
STRING	192952.MM_1418.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
EnsemblBacteria	AAM31114; AAM31114; MM_1418.
GeneID	1479760.
KEGG	mma:MM_1418.
Organism-specific databases
CMR	Search...
Phylogenomic databases
eggNOG	COG3635.
HOGENOM	HOG000004785.
KO	K15635.
OMA	YRHLMVW.
ProtClustDB	PRK04200.
Enzyme and pathway databases
UniPathway	UPA00109; UER00186.
Family and domain databases
Gene3D	3.40.720.10. 2 hits.
HAMAP	MF_01402_A. ApgM_A.
InterPro	IPR017849. Alkaline_Pase-like_a/b/a. IPR017850. Alkaline_phosphatase_core. IPR023665. ApgAM. IPR004456. BisP-indep_Pglycerate_Mutase. IPR013371. Homoserine_kinase_put. IPR006124. Metalloenzyme. [Graphical view]
Pfam	PF01676. Metalloenzyme. 1 hit. PF10143. PhosphMutase. 1 hit. [Graphical view]
PIRSF	PIRSF006392. IPGAM_arch. 1 hit.
SUPFAM	SSF53649. Alkaline_phosphatase_core. 1 hit.
TIGRFAMs	TIGR00306. apgM. 1 hit. TIGR02535. hyp_Hser_kinase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

APGM_METMA

Accession

Primary (citable) accession number: Q8PX04

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 10, 2002
Last modified:	May 1, 2013
This is version 74 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program