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Q8PWV5

- SYW_METMA

UniProt

Q8PWV5 - SYW_METMA

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 73 (01 Oct 2014)
      Sequence version 2 (08 Nov 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAZ192952:GCK2-1509-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tryptophan--tRNA ligase (EC:6.1.1.2)
    Alternative name(s):
    Tryptophanyl-tRNA synthetase
    Short name:
    TrpRS
    Gene namesi
    Name:trpS
    Ordered Locus Names:MM_1471
    OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
    Taxonomic identifieri192952 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000000595: Chromosome

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 491491Tryptophan--tRNA ligasePRO_0000136725Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi192952.MM_1471.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8PWV5.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni295 – 34955InsertAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi74 – 829"HIGH" region
    Motifi375 – 3795"KMSKS" region

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG0180.
    HOGENOMiHOG000224743.
    KOiK01867.
    OMAiSIYHRFM.

    Family and domain databases

    Gene3Di3.40.50.620. 2 hits.
    HAMAPiMF_00140_A. Trp_tRNA_synth_A.
    InterProiIPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view]
    PANTHERiPTHR10055. PTHR10055. 1 hit.
    PfamiPF00579. tRNA-synt_1b. 2 hits.
    [Graphical view]
    PRINTSiPR01039. TRNASYNTHTRP.

    Sequencei

    Sequence statusi: Complete.

    Q8PWV5-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDNKLDPWSS SNITDYSKLF EEFGISPFEN ILPEIPSPHK YMRRRIIFGH    50
    RDYEQIAEAM RTGAPFSVMD GFMPSGKVHL GHKMVMDQIV WHQEKGASAF 100
    VGIADREAFS VRGFSWQKCR EIGVEEYILS LIALGFKPEG LIYFQSGCGS 150
    VKDLAFELGA KVNFSELSAI YGFSGETSLS HMLSVATQAA DILQPQLEEF 200
    GGSKPVVVPV GPDQDPHLRL TRGLAGKMNM FRVEERETAE GGKYLSVRGK 250
    GAPREALQEL KKRIPGKVKL YEEHIDVLQT PDYAFLERFV LQINQPERRN 300
    YFMTQIQEIA TFANAAKPPE FSEYEKYFVF KRVWKTTGKI LEEVVAEVAA 350
    EFDGYAFIPP ASTYHRFMSG LQGGKMSSSI PDSHIALTDD PKEGAKKVKR 400
    AKTGGCITLE EQKKLGGKPD ECSVFELMLF HLIEDDEELL EIREECIYGT 450
    RMCGSCKQLA AEKMQEFLKD HQEKRELARE QLDEYRIIYK K 491
    Length:491
    Mass (Da):55,728
    Last modified:November 8, 2002 - v2
    Checksum:iD7ADE51A4F4E9D3C
    GO

    Sequence cautioni

    The sequence AAM31167.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008384 Genomic DNA. Translation: AAM31167.1. Different initiation.
    RefSeqiNP_633495.1. NC_003901.1.

    Genome annotation databases

    EnsemblBacteriaiAAM31167; AAM31167; MM_1471.
    GeneIDi1479813.
    KEGGimma:MM_1471.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008384 Genomic DNA. Translation: AAM31167.1 . Different initiation.
    RefSeqi NP_633495.1. NC_003901.1.

    3D structure databases

    ProteinModelPortali Q8PWV5.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 192952.MM_1471.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM31167 ; AAM31167 ; MM_1471 .
    GeneIDi 1479813.
    KEGGi mma:MM_1471.

    Phylogenomic databases

    eggNOGi COG0180.
    HOGENOMi HOG000224743.
    KOi K01867.
    OMAi SIYHRFM.

    Enzyme and pathway databases

    BioCyci MMAZ192952:GCK2-1509-MONOMER.

    Family and domain databases

    Gene3Di 3.40.50.620. 2 hits.
    HAMAPi MF_00140_A. Trp_tRNA_synth_A.
    InterProi IPR002305. aa-tRNA-synth_Ic.
    IPR014729. Rossmann-like_a/b/a_fold.
    IPR002306. Trp-tRNA-ligase.
    IPR020653. Tryptophan-tRNA-ligase_arc.
    [Graphical view ]
    PANTHERi PTHR10055. PTHR10055. 1 hit.
    Pfami PF00579. tRNA-synt_1b. 2 hits.
    [Graphical view ]
    PRINTSi PR01039. TRNASYNTHTRP.
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
      Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
      , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

    Entry informationi

    Entry nameiSYW_METMA
    AccessioniPrimary (citable) accession number: Q8PWV5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 8, 2002
    Last sequence update: November 8, 2002
    Last modified: October 1, 2014
    This is version 73 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3