Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8PWV5

- SYW_METMA

UniProt

Q8PWV5 - SYW_METMA

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Tryptophan--tRNA ligase

Gene

trpS

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophyl-tRNA(Trp).

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. tryptophan-tRNA ligase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. tryptophanyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-1509-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Tryptophan--tRNA ligase (EC:6.1.1.2)
Alternative name(s):
Tryptophanyl-tRNA synthetase
Short name:
TrpRS
Gene namesi
Name:trpS
Ordered Locus Names:MM_1471
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000000595: Chromosome

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 491491Tryptophan--tRNA ligasePRO_0000136725Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_1471.

Structurei

3D structure databases

ProteinModelPortaliQ8PWV5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni295 – 34955InsertAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi74 – 829"HIGH" region
Motifi375 – 3795"KMSKS" region

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0180.
HOGENOMiHOG000224743.
KOiK01867.
OMAiSIYHRFM.

Family and domain databases

Gene3Di3.40.50.620. 2 hits.
HAMAPiMF_00140_A. Trp_tRNA_synth_A.
InterProiIPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view]
PANTHERiPTHR10055. PTHR10055. 1 hit.
PfamiPF00579. tRNA-synt_1b. 2 hits.
[Graphical view]
PRINTSiPR01039. TRNASYNTHTRP.

Sequencei

Sequence statusi: Complete.

Q8PWV5-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MDNKLDPWSS SNITDYSKLF EEFGISPFEN ILPEIPSPHK YMRRRIIFGH
60 70 80 90 100
RDYEQIAEAM RTGAPFSVMD GFMPSGKVHL GHKMVMDQIV WHQEKGASAF
110 120 130 140 150
VGIADREAFS VRGFSWQKCR EIGVEEYILS LIALGFKPEG LIYFQSGCGS
160 170 180 190 200
VKDLAFELGA KVNFSELSAI YGFSGETSLS HMLSVATQAA DILQPQLEEF
210 220 230 240 250
GGSKPVVVPV GPDQDPHLRL TRGLAGKMNM FRVEERETAE GGKYLSVRGK
260 270 280 290 300
GAPREALQEL KKRIPGKVKL YEEHIDVLQT PDYAFLERFV LQINQPERRN
310 320 330 340 350
YFMTQIQEIA TFANAAKPPE FSEYEKYFVF KRVWKTTGKI LEEVVAEVAA
360 370 380 390 400
EFDGYAFIPP ASTYHRFMSG LQGGKMSSSI PDSHIALTDD PKEGAKKVKR
410 420 430 440 450
AKTGGCITLE EQKKLGGKPD ECSVFELMLF HLIEDDEELL EIREECIYGT
460 470 480 490
RMCGSCKQLA AEKMQEFLKD HQEKRELARE QLDEYRIIYK K
Length:491
Mass (Da):55,728
Last modified:November 8, 2002 - v2
Checksum:iD7ADE51A4F4E9D3C
GO

Sequence cautioni

The sequence AAM31167.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31167.1. Different initiation.
RefSeqiNP_633495.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM31167; AAM31167; MM_1471.
GeneIDi1479813.
KEGGimma:MM_1471.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31167.1 . Different initiation.
RefSeqi NP_633495.1. NC_003901.1.

3D structure databases

ProteinModelPortali Q8PWV5.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192952.MM_1471.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM31167 ; AAM31167 ; MM_1471 .
GeneIDi 1479813.
KEGGi mma:MM_1471.

Phylogenomic databases

eggNOGi COG0180.
HOGENOMi HOG000224743.
KOi K01867.
OMAi SIYHRFM.

Enzyme and pathway databases

BioCyci MMAZ192952:GCK2-1509-MONOMER.

Family and domain databases

Gene3Di 3.40.50.620. 2 hits.
HAMAPi MF_00140_A. Trp_tRNA_synth_A.
InterProi IPR002305. aa-tRNA-synth_Ic.
IPR014729. Rossmann-like_a/b/a_fold.
IPR002306. Trp-tRNA-ligase.
IPR020653. Tryptophan-tRNA-ligase_arc.
[Graphical view ]
PANTHERi PTHR10055. PTHR10055. 1 hit.
Pfami PF00579. tRNA-synt_1b. 2 hits.
[Graphical view ]
PRINTSi PR01039. TRNASYNTHTRP.
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
    Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
    , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Entry informationi

Entry nameiSYW_METMA
AccessioniPrimary (citable) accession number: Q8PWV5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: November 8, 2002
Last modified: October 29, 2014
This is version 74 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3