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Q8PWA0

- SYK1_METMA

UniProt

Q8PWA0 - SYK1_METMA

Protein

Lysine--tRNA ligase 1

Gene

lysS1

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi
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    • History
      Entry version 72 (01 Oct 2014)
      Sequence version 1 (25 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
    3. tRNA binding Source: InterPro

    GO - Biological processi

    1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP

    Keywords - Molecular functioni

    Aminoacyl-tRNA synthetase, Ligase

    Keywords - Biological processi

    Protein biosynthesis

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMMAZ192952:GCK2-1739-MONOMER.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysine--tRNA ligase 1UniRule annotation (EC:6.1.1.6UniRule annotation)
    Alternative name(s):
    Lysyl-tRNA synthetase 1UniRule annotation
    Short name:
    LysRS 1UniRule annotation
    Gene namesi
    Name:lysS1UniRule annotation
    Synonyms:lysS
    Ordered Locus Names:MM_1696
    OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
    Taxonomic identifieri192952 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000000595: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 537537Lysine--tRNA ligase 1PRO_0000152755Add
    BLAST

    Interactioni

    Protein-protein interaction databases

    STRINGi192952.MM_1696.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8PWA0.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi30 – 389"HIGH" region
    Motifi276 – 2805"KMSKS" region

    Sequence similaritiesi

    Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1384.
    HOGENOMiHOG000226938.
    KOiK04566.
    OMAiWPARWSI.

    Family and domain databases

    Gene3Di1.10.10.350. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPiMF_00177. Lys_tRNA_synth_class1.
    InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view]
    PfamiPF01921. tRNA-synt_1f. 1 hit.
    [Graphical view]
    SUPFAMiSSF48163. SSF48163. 1 hit.
    TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
    PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8PWA0-1 [UniParc]FASTAAdd to Basket

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    MADTIHWADV IAEDVLNKSG KHLVATGITP SGHIHIGNMR EVVTADAAYR    50
    ALLDRGADAR FIYIADNFDP LRKVYPFLPE SYAEHVGKPI SEVPCPCGEC 100
    ANYSEHFLKP FLEALRRLGI NPEVYRADEM YRAGMYTEAI KTALVKRNEI 150
    AKILEEVSGK TVAEEWSPFN PRCNECGKIT TTKVTGFDPD AETVDYVCAC 200
    GHSGTVPMAG GGKLTWRVDW PARWAVLGVT VEPFGKDHAS RGGSYDTGKR 250
    IVREIYGHEP PFPIVYEWIM LGKQGAMSSS TGVVVSISDM LEVVPPEVLR 300
    YLIIRTKPEK HIQFDPAQPL LTIVDEYERL REKFRDNDPS MGEFEKRIYE 350
    LSRATGICHP EIPFKQMVTI FQVARGNFEQ ILQIVKRSGF STEDEKCIRE 400
    LVDNVSKWLE LYAPPFAKFS VKENVPVQVA TLSELQKAFL GAFADLIESK 450
    GKISGEEYHM LVYSAKEKGS ELNRLIAEKL NVPAPQVDPK DLFKAIYTSI 500
    LGQSSGPKAG WFLSSFEEDF LINRFREAST YSPEKRE 537
    Length:537
    Mass (Da):60,333
    Last modified:October 25, 2002 - v1
    Checksum:iB8666F036BA375DD
    GO

    Sequence cautioni

    The sequence AAM31392.1 differs from that shown. Reason: Erroneous initiation.

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008384 Genomic DNA. Translation: AAM31392.1. Different initiation.
    RefSeqiNP_633720.1. NC_003901.1.

    Genome annotation databases

    EnsemblBacteriaiAAM31392; AAM31392; MM_1696.
    GeneIDi1480038.
    KEGGimma:MM_1696.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008384 Genomic DNA. Translation: AAM31392.1 . Different initiation.
    RefSeqi NP_633720.1. NC_003901.1.

    3D structure databases

    ProteinModelPortali Q8PWA0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 192952.MM_1696.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM31392 ; AAM31392 ; MM_1696 .
    GeneIDi 1480038.
    KEGGi mma:MM_1696.

    Phylogenomic databases

    eggNOGi COG1384.
    HOGENOMi HOG000226938.
    KOi K04566.
    OMAi WPARWSI.

    Enzyme and pathway databases

    BioCyci MMAZ192952:GCK2-1739-MONOMER.

    Family and domain databases

    Gene3Di 1.10.10.350. 1 hit.
    3.40.50.620. 2 hits.
    HAMAPi MF_00177. Lys_tRNA_synth_class1.
    InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
    IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
    IPR001412. aa-tRNA-synth_I_CS.
    IPR002904. Lys-tRNA-ligase.
    IPR014729. Rossmann-like_a/b/a_fold.
    [Graphical view ]
    Pfami PF01921. tRNA-synt_1f. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48163. SSF48163. 1 hit.
    TIGRFAMsi TIGR00467. lysS_arch. 1 hit.
    PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
      Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
      , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

    Entry informationi

    Entry nameiSYK1_METMA
    AccessioniPrimary (citable) accession number: Q8PWA0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 25, 2002
    Last sequence update: October 25, 2002
    Last modified: October 1, 2014
    This is version 72 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programProkaryotic Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Aminoacyl-tRNA synthetases
      List of aminoacyl-tRNA synthetase entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3