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Q8PWA0

- SYK1_METMA

UniProt

Q8PWA0 - SYK1_METMA

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Protein

Lysine--tRNA ligase 1

Gene
lysS1, lysS, MM_1696
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-1739-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase 1 (EC:6.1.1.6)
Alternative name(s):
Lysyl-tRNA synthetase 1
Short name:
LysRS 1
Gene namesi
Name:lysS1
Synonyms:lysS
Ordered Locus Names:MM_1696
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000000595: Chromosome

Subcellular locationi

Cytoplasm By similarity UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Lysine--tRNA ligase 1UniRule annotationPRO_0000152755Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_1696.

Structurei

3D structure databases

ProteinModelPortaliQ8PWA0.

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 389"HIGH" regionUniRule annotation
Motifi276 – 2805"KMSKS" regionUniRule annotation

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1384.
HOGENOMiHOG000226938.
KOiK04566.
OMAiWPARWSI.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8PWA0-1 [UniParc]FASTAAdd to Basket

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MADTIHWADV IAEDVLNKSG KHLVATGITP SGHIHIGNMR EVVTADAAYR    50
ALLDRGADAR FIYIADNFDP LRKVYPFLPE SYAEHVGKPI SEVPCPCGEC 100
ANYSEHFLKP FLEALRRLGI NPEVYRADEM YRAGMYTEAI KTALVKRNEI 150
AKILEEVSGK TVAEEWSPFN PRCNECGKIT TTKVTGFDPD AETVDYVCAC 200
GHSGTVPMAG GGKLTWRVDW PARWAVLGVT VEPFGKDHAS RGGSYDTGKR 250
IVREIYGHEP PFPIVYEWIM LGKQGAMSSS TGVVVSISDM LEVVPPEVLR 300
YLIIRTKPEK HIQFDPAQPL LTIVDEYERL REKFRDNDPS MGEFEKRIYE 350
LSRATGICHP EIPFKQMVTI FQVARGNFEQ ILQIVKRSGF STEDEKCIRE 400
LVDNVSKWLE LYAPPFAKFS VKENVPVQVA TLSELQKAFL GAFADLIESK 450
GKISGEEYHM LVYSAKEKGS ELNRLIAEKL NVPAPQVDPK DLFKAIYTSI 500
LGQSSGPKAG WFLSSFEEDF LINRFREAST YSPEKRE 537
Length:537
Mass (Da):60,333
Last modified:October 25, 2002 - v1
Checksum:iB8666F036BA375DD
GO

Sequence cautioni

The sequence AAM31392.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM31392.1. Different initiation.
RefSeqiNP_633720.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM31392; AAM31392; MM_1696.
GeneIDi1480038.
KEGGimma:MM_1696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM31392.1 . Different initiation.
RefSeqi NP_633720.1. NC_003901.1.

3D structure databases

ProteinModelPortali Q8PWA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192952.MM_1696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM31392 ; AAM31392 ; MM_1696 .
GeneIDi 1480038.
KEGGi mma:MM_1696.

Phylogenomic databases

eggNOGi COG1384.
HOGENOMi HOG000226938.
KOi K04566.
OMAi WPARWSI.

Enzyme and pathway databases

BioCyci MMAZ192952:GCK2-1739-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00177. Lys_tRNA_synth_class1.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF01921. tRNA-synt_1f. 1 hit.
[Graphical view ]
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00467. lysS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
    Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
    , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Entry informationi

Entry nameiSYK1_METMA
AccessioniPrimary (citable) accession number: Q8PWA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: May 14, 2014
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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