Reviewed,
UniProtKB/Swiss-Prot Q8PWA0 (SYK1_METMA)
Last modified
June 16, 2009.
Version 41.
History...
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Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents
Names and origin
| Protein names | Recommended name: Lysyl-tRNA synthetase 1 EC=6.1.1.6 Alternative name(s): Lysine--tRNA ligase 1 Short name=LysRS 1 | ||||||
| Gene names |
| ||||||
| Organism | Methanosarcina mazei (Methanosarcina frisia) [Complete proteome] [HAMAP] | ||||||
| Taxonomic identifier | 2209 [NCBI] | ||||||
| Taxonomic lineage | Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina |
Protein attributes
| Sequence length | 537 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Inferred from homology. |
General annotation (Comments)
| Catalytic activity | ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys). HAMAP MF_00177 |
| Subcellular location | |
| Sequence similarities | Belongs to the class-I aminoacyl-tRNA synthetase family. |
Ontologies
| Keywords | |
|---|---|
| Biological process | Protein biosynthesis |
| Cellular component | Cytoplasm |
| Ligand | ATP-binding Nucleotide-binding |
| Molecular function | Aminoacyl-tRNA synthetase Ligase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | lysyl-tRNA aminoacylation Inferred from electronic annotation. Source: HAMAP |
| Cellular component | cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell |
| Molecular function | ATP binding Inferred from electronic annotation. Source: HAMAP lysine-tRNA ligase activityInferred from electronic annotation. Source: HAMAP |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 537 | 537 | Lysyl-tRNA synthetase 1 HAMAP MF_00177 | PRO_0000152755 | |||||
Regions | |||||||||
| Motif | 30 – 38 | 9 | "HIGH" region HAMAP MF_00177 | ||||||
| Motif | 276 – 280 | 5 | "KMSKS" region HAMAP MF_00177 | ||||||
Sequences
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References
| [1] | "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. Gottschalk G.J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88. |
Cross-references
Sequence databases | |
|---|---|
| AE008384 Genomic DNA. Translation: AAM31392.1. Different initiation. | |
| RefSeq | NP_633720.1. |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IRX based on UniProtKB O57963. |
| ModBase | Search... |
Genome annotation databases | |
| GeneID | 1480038. |
| GenomeReviews | Gene locus MM_1696 in contig AE008384_GR. |
| KEGG | mma:MM_1696. |
| NMPDR | fig|192952.1.peg.1696. |
Organism-specific databases | |
| CMR | Search... |
Phylogenomic databases | |
| HOGENOM | Q8PWA0. |
Enzyme and pathway databases | |
| BioCyc | MMAZ192952:MM1696-MON. |
| BRENDA | 6.1.1.6. 261165. |
Family and domain databases | |
| HAMAP | MF_00177. [Tree] |
| InterPro | IPR008925. aa-tRNA-synth_I_codon-bd. IPR001412. aa-tRNA-synth_I_CS. IPR002904. Lys-tRNA-synth_Ic_arc-type. IPR014729. Rossmann-like_a/b/a_fold. [Graphical view] |
| Gene3D | G3DSA:3.40.50.620. Rossmann-like_a/b/a_fold. 1 hit. G3DSA:1.10.10.350. tRNA_synt_bd. 1 hit. |
| Pfam | PF01921. tRNA-synt_1f. 1 hit. [Graphical view] |
| TIGRFAMs | TIGR00467. lysS_arch. 1 hit. |
| PROSITE | PS00178. AA_TRNA_LIGASE_I. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Entry information
| Entry name | SYK1_METMA | ||||||||
| Accession | Primary (citable) accession number: Q8PWA0 | ||||||||
| Entry history |
| ||||||||
| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes) | ||||||||
Relevant documents
| Aminoacyl-tRNA synthetases List of aminoacyl-tRNA synthetase entries |
| SIMILARITY comments Index of protein domains and families |

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