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Protein

Lysine--tRNA ligase 1

Gene

lysS1

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase 1UniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetase 1UniRule annotation
Short name:
LysRS 1UniRule annotation
Gene namesi
Name:lysS1UniRule annotation
Synonyms:lysS
Ordered Locus Names:MM_1696
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001527551 – 537Lysine--tRNA ligase 1Add BLAST537

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_1696

Structurei

3D structure databases

ProteinModelPortaliQ8PWA0
SMRiQ8PWA0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi30 – 38"HIGH" region9
Motifi276 – 280"KMSKS" region5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG00485 Archaea
COG1384 LUCA
HOGENOMiHOG000226938
KOiK04566
OMAiDWPMRWA
OrthoDBiPOG093Z01CB

Family and domain databases

Gene3Di1.10.10.350, 1 hit
2.30.30.300, 1 hit
3.40.50.620, 2 hits
HAMAPiMF_00177 Lys_tRNA_synth_class1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR002904 Lys-tRNA-ligase
IPR023386 Lys-tRNA-ligase_insertion_sf
IPR014729 Rossmann-like_a/b/a_fold
PANTHERiPTHR37940 PTHR37940, 1 hit
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00467 lysS_arch, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PWA0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MADTIHWADV IAEDVLNKSG KHLVATGITP SGHIHIGNMR EVVTADAAYR
60 70 80 90 100
ALLDRGADAR FIYIADNFDP LRKVYPFLPE SYAEHVGKPI SEVPCPCGEC
110 120 130 140 150
ANYSEHFLKP FLEALRRLGI NPEVYRADEM YRAGMYTEAI KTALVKRNEI
160 170 180 190 200
AKILEEVSGK TVAEEWSPFN PRCNECGKIT TTKVTGFDPD AETVDYVCAC
210 220 230 240 250
GHSGTVPMAG GGKLTWRVDW PARWAVLGVT VEPFGKDHAS RGGSYDTGKR
260 270 280 290 300
IVREIYGHEP PFPIVYEWIM LGKQGAMSSS TGVVVSISDM LEVVPPEVLR
310 320 330 340 350
YLIIRTKPEK HIQFDPAQPL LTIVDEYERL REKFRDNDPS MGEFEKRIYE
360 370 380 390 400
LSRATGICHP EIPFKQMVTI FQVARGNFEQ ILQIVKRSGF STEDEKCIRE
410 420 430 440 450
LVDNVSKWLE LYAPPFAKFS VKENVPVQVA TLSELQKAFL GAFADLIESK
460 470 480 490 500
GKISGEEYHM LVYSAKEKGS ELNRLIAEKL NVPAPQVDPK DLFKAIYTSI
510 520 530
LGQSSGPKAG WFLSSFEEDF LINRFREAST YSPEKRE
Length:537
Mass (Da):60,333
Last modified:October 25, 2002 - v1
Checksum:iB8666F036BA375DD
GO

Sequence cautioni

The sequence AAM31392 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA Translation: AAM31392.1 Different initiation.
RefSeqiWP_015412023.1, NC_003901.1

Genome annotation databases

EnsemblBacteriaiAAM31392; AAM31392; MM_1696
GeneIDi24881383
KEGGimma:MM_1696
PATRICifig|192952.21.peg.1970

Similar proteinsi

Entry informationi

Entry nameiSYK1_METMA
AccessioniPrimary (citable) accession number: Q8PWA0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: March 28, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

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