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Q8PWA0

- SYK1_METMA

UniProt

Q8PWA0 - SYK1_METMA

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Protein

Lysine--tRNA ligase 1

Gene

lysS1

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 2 out of 5- Protein inferred from homologyi

Functioni

Catalytic activityi

ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys).UniRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. lysine-tRNA ligase activity Source: UniProtKB-HAMAP
  3. tRNA binding Source: InterPro

GO - Biological processi

  1. lysyl-tRNA aminoacylation Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Aminoacyl-tRNA synthetase, Ligase

Keywords - Biological processi

Protein biosynthesis

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-1739-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysine--tRNA ligase 1UniRule annotation (EC:6.1.1.6UniRule annotation)
Alternative name(s):
Lysyl-tRNA synthetase 1UniRule annotation
Short name:
LysRS 1UniRule annotation
Gene namesi
Name:lysS1UniRule annotation
Synonyms:lysS
Ordered Locus Names:MM_1696
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000000595: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 537537Lysine--tRNA ligase 1PRO_0000152755Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_1696.

Structurei

3D structure databases

ProteinModelPortaliQ8PWA0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi30 – 389"HIGH" region
Motifi276 – 2805"KMSKS" region

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1384.
HOGENOMiHOG000226938.
KOiK04566.
OMAiWPARWSI.

Family and domain databases

Gene3Di1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPiMF_00177. Lys_tRNA_synth_class1.
InterProiIPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamiPF01921. tRNA-synt_1f. 1 hit.
[Graphical view]
SUPFAMiSSF48163. SSF48163. 1 hit.
TIGRFAMsiTIGR00467. lysS_arch. 1 hit.
PROSITEiPS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8PWA0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MADTIHWADV IAEDVLNKSG KHLVATGITP SGHIHIGNMR EVVTADAAYR
60 70 80 90 100
ALLDRGADAR FIYIADNFDP LRKVYPFLPE SYAEHVGKPI SEVPCPCGEC
110 120 130 140 150
ANYSEHFLKP FLEALRRLGI NPEVYRADEM YRAGMYTEAI KTALVKRNEI
160 170 180 190 200
AKILEEVSGK TVAEEWSPFN PRCNECGKIT TTKVTGFDPD AETVDYVCAC
210 220 230 240 250
GHSGTVPMAG GGKLTWRVDW PARWAVLGVT VEPFGKDHAS RGGSYDTGKR
260 270 280 290 300
IVREIYGHEP PFPIVYEWIM LGKQGAMSSS TGVVVSISDM LEVVPPEVLR
310 320 330 340 350
YLIIRTKPEK HIQFDPAQPL LTIVDEYERL REKFRDNDPS MGEFEKRIYE
360 370 380 390 400
LSRATGICHP EIPFKQMVTI FQVARGNFEQ ILQIVKRSGF STEDEKCIRE
410 420 430 440 450
LVDNVSKWLE LYAPPFAKFS VKENVPVQVA TLSELQKAFL GAFADLIESK
460 470 480 490 500
GKISGEEYHM LVYSAKEKGS ELNRLIAEKL NVPAPQVDPK DLFKAIYTSI
510 520 530
LGQSSGPKAG WFLSSFEEDF LINRFREAST YSPEKRE
Length:537
Mass (Da):60,333
Last modified:October 25, 2002 - v1
Checksum:iB8666F036BA375DD
GO

Sequence cautioni

The sequence AAM31392.1 differs from that shown. Reason: Erroneous initiation. Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31392.1. Different initiation.
RefSeqiNP_633720.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM31392; AAM31392; MM_1696.
GeneIDi1480038.
KEGGimma:MM_1696.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31392.1 . Different initiation.
RefSeqi NP_633720.1. NC_003901.1.

3D structure databases

ProteinModelPortali Q8PWA0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192952.MM_1696.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM31392 ; AAM31392 ; MM_1696 .
GeneIDi 1480038.
KEGGi mma:MM_1696.

Phylogenomic databases

eggNOGi COG1384.
HOGENOMi HOG000226938.
KOi K04566.
OMAi WPARWSI.

Enzyme and pathway databases

BioCyci MMAZ192952:GCK2-1739-MONOMER.

Family and domain databases

Gene3Di 1.10.10.350. 1 hit.
3.40.50.620. 2 hits.
HAMAPi MF_00177. Lys_tRNA_synth_class1.
InterProi IPR008925. aa-tRNA-synth_I_codon-bd.
IPR020751. aa-tRNA-synth_I_codon-bd_sub2.
IPR001412. aa-tRNA-synth_I_CS.
IPR002904. Lys-tRNA-ligase.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view ]
Pfami PF01921. tRNA-synt_1f. 1 hit.
[Graphical view ]
SUPFAMi SSF48163. SSF48163. 1 hit.
TIGRFAMsi TIGR00467. lysS_arch. 1 hit.
PROSITEi PS00178. AA_TRNA_LIGASE_I. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
    Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
    , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Entry informationi

Entry nameiSYK1_METMA
AccessioniPrimary (citable) accession number: Q8PWA0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: October 29, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Aminoacyl-tRNA synthetases
    List of aminoacyl-tRNA synthetase entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3