Q8PW59 (Q8PW59_METMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Delta-aminolevulinic acid dehydratase EMBL AAM31438.1
EC=4.2.1.24 EMBL AAM31438.1

Gene names

Ordered Locus Names:

MM_1742

Organism

Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP] EMBL AAM31438.1

Taxonomic identifier

192952 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	324 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Subunit structure

Homooctamer By similarity. PIRSR PIRSR001415-3

Ontologies

Keywords
Ligand	Magnesium PIRSR PIRSR001415-5 Metal-binding PIRSR PIRSR001415-3 Zinc PIRSR PIRSR001415-3
Molecular function	Lyase EMBL AAM31438.1
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	porphyrin-containing compound biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW porphobilinogen synthase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Sites
	Active site	196	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Active site	249	1	Schiff-base intermediate with substrate By similarity PIRSR PIRSR001415-1
	Metal binding	119	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	121	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	129	1	Zinc; catalytic By similarity PIRSR PIRSR001415-3
	Metal binding	234	1	Magnesium By similarity PIRSR PIRSR001415-5
	Binding site	206	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	218	1	Substrate 1 By similarity PIRSR PIRSR001415-2
	Binding site	275	1	Substrate 2 By similarity PIRSR PIRSR001415-2
	Binding site	314	1	Substrate 2 By similarity PIRSR PIRSR001415-2

Sequences

	Sequence		Length	Mass (Da)
	Q8PW59 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 1B4DBE4666E1F893	FASTA	324	35,399
	10 20 30 40 50 60 MFPEIRLRRL RKGKIRDLVR ETTLSVDDLV MPIFVNENID SPVEISSMPG IYNFPLSEVA 70 80 90 100 110 120 KEAKEIADLG IPAVILFGVP AFKDAEGSTS CGENDVVQEA VRRIKAELGN RLVVITDICM 130 140 150 160 170 180 CEFTSHGHCG IVDFETQEVL NDPTLEVLGK IAVSHARAGA DMVAPSGMMD GMVGAIRMAL 190 200 210 220 230 240 DASGFENIPI MSYAAKYHSC FYGPFREAAE SGYSFGDRST YQMDPANSDE ALREVALDVA 250 260 270 280 290 300 EGADILMVKP GLPYLDIVYR VKSEFGMPTA AYNVSGEYSM IKAAAASGWI DEKKAIYESL 310 320 ISIKRAGADF IITYFAKDAA RMLK

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

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Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008384 Genomic DNA. Translation: AAM31438.1.
RefSeq	NP_633766.1. NC_003901.1.
3D structure databases
HSSP	HSSP built from PDB template 1B4K based on UniProtKB Q59643.
ProteinModelPortal	Q8PW59.
SMR	Q8PW59. Positions 5-324.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1480084.
GenomeReviews	Gene locus MM_1742 in contig AE008384_GR.
KEGG	mma:MM_1742.
NMPDR	fig|192952.1.peg.1742.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG285270.
OMA	ADLCFCE.
PhylomeDB	Q8PW59.
ProtClustDB	PRK09283.
Family and domain databases
InterPro	IPR013785. Aldolase_TIM. IPR001731. Porphobilinogen_synth. [Graphical view]
Gene3D	G3DSA:3.20.20.70. Aldolase_TIM. 1 hit.
KO	K01698.
PANTHER	PTHR11458. AlaD_dehydratase. 1 hit.
Pfam	PF00490. ALAD. 1 hit. [Graphical view]
PIRSF	PIRSF001415. Porphbilin_synth. 1 hit.
PRINTS	PR00144. DALDHYDRTASE.
SMART	SM01004. ALAD. 1 hit. [Graphical view]
PROSITE	PS00169. D_ALA_DEHYDRATASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

Q8PW59_METMA

Accession

Primary (citable) accession number: Q8PW59

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 56 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)