Q8PW39 (Q8PW39_METMA) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Mevalonate kinase EMBL AAM31458.1
EC=2.7.1.36 EMBL AAM31458.1

Gene names

Ordered Locus Names:

MM_1762

Organism

Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP] EMBL AAM31458.1

Taxonomic identifier

192952 [NCBI]

Taxonomic lineage

cellular organisms › Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina › Methanosarcina mazei

Protein attributes

Sequence length	301 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Sequence similarities

Belongs to the GHMP kinase family. RuleBase RU004209

Ontologies

Keywords
Ligand	ATP-binding RuleBase RU003563 Nucleotide-binding
Molecular function	Kinase RuleBase RU003563 EMBL AAM31458.1 Transferase
Technical term	3D-structure PDB 4HAC Complete proteome
Gene Ontology (GO)
Biological_process	isoprenoid biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular_component	cytoplasm Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW mevalonate kinase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8PW39 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: CF223C2CE893D62D	FASTA	301	31,412
	10 20 30 40 50 60 MVSCSAPGKI YLFGEHAVVY GETAIACAVE LRTRVRAELN DSITIQSQIG RTGLDFEKHP 70 80 90 100 110 120 YVSAVIEKMR KSIPINGVFL TVDSDIPVGS GLGSSAAVTI ASIGALNELF GFGLSLQEIA 130 140 150 160 170 180 KLGHEIEIKV QGAASPTDTY VSTFGGVVTI PERRKLKTPD CGIVIGDTGV FSSTKELVAN 190 200 210 220 230 240 VRQLRESYPD LIEPLMTSIG KISRIGEQLV LSGDYASIGR LMNVNQGLLD ALGVNILELS 250 260 270 280 290 300 QLIYSARAAG AFGAKITGAG GGGCMVALTA PEKCNQVAEA VAGAGGKVTI TKPTEQGLKV D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.
[2]	"Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei." Zhuang N., Seo K.H., Chen C., Zhou J., Kim S.W., Lee K.H. Acta Crystallogr. F 68:1560-1563(2012) [PubMed] [Europe PMC] [Abstract] Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

AE008384 Genomic DNA. Translation: AAM31458.1.

RefSeq

NP_633786.1. NC_003901.1.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
4HAC	X-ray	1.92	A/B	1-301	[»]

HSSP

HSSP built from PDB template 1KVK based on UniProtKB P17256.

ProteinModelPortal

Q8PW39.

ModBase

Search...

Protein-protein interaction databases

STRING

192952.MM_1762.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

EnsemblBacteria

AAM31458; AAM31458; MM_1762.

GeneID

1480104.

KEGG

mma:MM_1762.

Organism-specific databases

CMR

Search...

Phylogenomic databases

eggNOG

COG1577.

HOGENOM

HOG000080810.

KO

K00869.

OMA

CMYALAP.

ProtClustDB

PRK03926.

Family and domain databases

Gene3D

3.30.230.10. 1 hit.

InterPro

IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006205. Mev_gal_kin.
IPR006206. Mevalonate/galactokinase.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]

PANTHER

PTHR10457:SF4. PTHR10457:SF4. 1 hit.

Pfam

PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]

PRINTS

PR00959. MEVGALKINASE.

SUPFAM

SSF54211. Ribosomal_S5_D2-typ_fold. 1 hit.

TIGRFAMs

TIGR00549. mevalon_kin. 1 hit.

PROSITE

PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

ProtoNet

Search...

Entry information

Entry name

Q8PW39_METMA

Accession

Primary (citable) accession number: Q8PW39

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	May 1, 2013
This is version 76 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)