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Q8PW39

- Q8PW39_METMA

UniProt

Q8PW39 - Q8PW39_METMA

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Protein

Mevalonate kinase

Gene

mvk

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.UniRule annotation

Catalytic activityi

ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.UniRule annotation

Cofactori

Note: Magnesium.UniRule annotation

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei138 – 1381Proton acceptorUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi87 – 9711ATPUniRule annotationAdd
BLAST

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. magnesium ion binding Source: UniProtKB-HAMAP
  3. mevalonate kinase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. isopentenyl diphosphate biosynthetic process, mevalonate pathway Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

KinaseUniRule annotation, Transferase

Keywords - Biological processi

Isoprene biosynthesisUniRule annotation, Lipid biosynthesisUniRule annotation, Lipid metabolism

Keywords - Ligandi

ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Nucleotide-binding

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-18243.
MMAZ192952:GCK2-1806-MONOMER.
UniPathwayiUPA00057; UER00098.

Names & Taxonomyi

Protein namesi
Recommended name:
Mevalonate kinaseUniRule annotation (EC:2.7.1.36UniRule annotation)
Short name:
MKUniRule annotation
Short name:
MVKUniRule annotation
Gene namesi
Name:mvkUniRule annotation
Ordered Locus Names:MM_1762Imported
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)Imported
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000000595: Chromosome

Subcellular locationi

Cytoplasm UniRule annotation

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

CytoplasmUniRule annotation

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi192952.MM_1762.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4HACX-ray1.92A/B1-301[»]
ProteinModelPortaliQ8PW39.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GHMP kinase family. Mevalonate kinase subfamily.UniRule annotation

Phylogenomic databases

eggNOGiCOG1577.
HOGENOMiHOG000080810.
KOiK00869.
OMAiAMAIKPR.

Family and domain databases

Gene3Di3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPiMF_00217. Mevalonate_kinase.
InterProiIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006205. Mev_gal_kin.
IPR006206. Mevalonate/galactokinase.
IPR022937. Mevalonate_kinase_arc.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PANTHERiPTHR10457:SF10. PTHR10457:SF10. 1 hit.
PfamiPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSiPR00959. MEVGALKINASE.
SUPFAMiSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsiTIGR00549. mevalon_kin. 1 hit.
PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8PW39-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MVSCSAPGKI YLFGEHAVVY GETAIACAVE LRTRVRAELN DSITIQSQIG
60 70 80 90 100
RTGLDFEKHP YVSAVIEKMR KSIPINGVFL TVDSDIPVGS GLGSSAAVTI
110 120 130 140 150
ASIGALNELF GFGLSLQEIA KLGHEIEIKV QGAASPTDTY VSTFGGVVTI
160 170 180 190 200
PERRKLKTPD CGIVIGDTGV FSSTKELVAN VRQLRESYPD LIEPLMTSIG
210 220 230 240 250
KISRIGEQLV LSGDYASIGR LMNVNQGLLD ALGVNILELS QLIYSARAAG
260 270 280 290 300
AFGAKITGAG GGGCMVALTA PEKCNQVAEA VAGAGGKVTI TKPTEQGLKV

D
Length:301
Mass (Da):31,412
Last modified:October 1, 2002 - v1
Checksum:iCF223C2CE893D62D
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31458.1.
RefSeqiNP_633786.1. NC_003901.1.
WP_011033702.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM31458; AAM31458; MM_1762.
GeneIDi1480104.
KEGGimma:MM_1762.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31458.1 .
RefSeqi NP_633786.1. NC_003901.1.
WP_011033702.1. NC_003901.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4HAC X-ray 1.92 A/B 1-301 [» ]
ProteinModelPortali Q8PW39.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192952.MM_1762.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM31458 ; AAM31458 ; MM_1762 .
GeneIDi 1480104.
KEGGi mma:MM_1762.

Phylogenomic databases

eggNOGi COG1577.
HOGENOMi HOG000080810.
KOi K00869.
OMAi AMAIKPR.

Enzyme and pathway databases

UniPathwayi UPA00057 ; UER00098 .
BioCyci MetaCyc:MONOMER-18243.
MMAZ192952:GCK2-1806-MONOMER.

Family and domain databases

Gene3Di 3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPi MF_00217. Mevalonate_kinase.
InterProi IPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006205. Mev_gal_kin.
IPR006206. Mevalonate/galactokinase.
IPR022937. Mevalonate_kinase_arc.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view ]
PANTHERi PTHR10457:SF10. PTHR10457:SF10. 1 hit.
Pfami PF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view ]
PRINTSi PR00959. MEVGALKINASE.
SUPFAMi SSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsi TIGR00549. mevalon_kin. 1 hit.
PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
    Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
    , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88Imported.
  2. "Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei."
    Zhuang N., Seo K.H., Chen C., Zhou J., Kim S.W., Lee K.H.
    Acta Crystallogr. F 68:1560-1563(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS).

Entry informationi

Entry nameiQ8PW39_METMA
AccessioniPrimary (citable) accession number: Q8PW39
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureImported, Complete proteome, Reference proteomeImported

External Data

Dasty 3