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Q8PW39

- Q8PW39_METMA

UniProt

Q8PW39 - Q8PW39_METMA

Protein

Mevalonate kinase

Gene

mvk

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Unreviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.UniRule annotation

    Catalytic activityi

    ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate.UniRule annotation

    Cofactori

    Magnesium.UniRule annotation

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei138 – 1381Proton acceptorUniRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi87 – 9711ATPUniRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-HAMAP
    2. magnesium ion binding Source: UniProtKB-HAMAP
    3. mevalonate kinase activity Source: UniProtKB-HAMAP

    GO - Biological processi

    1. isopentenyl diphosphate biosynthetic process, mevalonate pathway Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    KinaseUniRule annotationImported, Transferase

    Keywords - Biological processi

    Isoprene biosynthesisUniRule annotation, Lipid biosynthesisUniRule annotation, Lipid metabolism

    Keywords - Ligandi

    ATP-bindingUniRule annotation, MagnesiumUniRule annotation, Nucleotide-binding

    Enzyme and pathway databases

    BioCyciMetaCyc:MONOMER-18243.
    MMAZ192952:GCK2-1806-MONOMER.
    UniPathwayiUPA00057; UER00098.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mevalonate kinaseUniRule annotation (EC:2.7.1.36UniRule annotation)
    Short name:
    MKUniRule annotation
    Short name:
    MVKUniRule annotation
    Gene namesi
    Name:mvkUniRule annotation
    Ordered Locus Names:MM_1762Imported
    OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)Imported
    Taxonomic identifieri192952 [NCBI]
    Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
    ProteomesiUP000000595: Chromosome

    Subcellular locationi

    Cytoplasm UniRule annotation

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    CytoplasmUniRule annotation

    Interactioni

    Subunit structurei

    Homodimer.UniRule annotation

    Protein-protein interaction databases

    STRINGi192952.MM_1762.

    Structurei

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4HACX-ray1.92A/B1-301[»]
    ProteinModelPortaliQ8PW39.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the GHMP kinase family. Mevalonate kinase subfamily.UniRule annotation

    Phylogenomic databases

    eggNOGiCOG1577.
    HOGENOMiHOG000080810.
    KOiK00869.
    OMAiAMAIKPR.

    Family and domain databases

    Gene3Di3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPiMF_00217. Mevalonate_kinase.
    InterProiIPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006205. Mev_gal_kin.
    IPR006206. Mevalonate/galactokinase.
    IPR022937. Mevalonate_kinase_arc.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view]
    PANTHERiPTHR10457:SF10. PTHR10457:SF10. 1 hit.
    PfamiPF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view]
    PRINTSiPR00959. MEVGALKINASE.
    SUPFAMiSSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsiTIGR00549. mevalon_kin. 1 hit.
    PROSITEiPS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8PW39-1 [UniParc]FASTAAdd to Basket

    « Hide

    MVSCSAPGKI YLFGEHAVVY GETAIACAVE LRTRVRAELN DSITIQSQIG    50
    RTGLDFEKHP YVSAVIEKMR KSIPINGVFL TVDSDIPVGS GLGSSAAVTI 100
    ASIGALNELF GFGLSLQEIA KLGHEIEIKV QGAASPTDTY VSTFGGVVTI 150
    PERRKLKTPD CGIVIGDTGV FSSTKELVAN VRQLRESYPD LIEPLMTSIG 200
    KISRIGEQLV LSGDYASIGR LMNVNQGLLD ALGVNILELS QLIYSARAAG 250
    AFGAKITGAG GGGCMVALTA PEKCNQVAEA VAGAGGKVTI TKPTEQGLKV 300
    D 301
    Length:301
    Mass (Da):31,412
    Last modified:October 1, 2002 - v1
    Checksum:iCF223C2CE893D62D
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008384 Genomic DNA. Translation: AAM31458.1.
    RefSeqiNP_633786.1. NC_003901.1.
    WP_011033702.1. NC_003901.1.

    Genome annotation databases

    EnsemblBacteriaiAAM31458; AAM31458; MM_1762.
    GeneIDi1480104.
    KEGGimma:MM_1762.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AE008384 Genomic DNA. Translation: AAM31458.1 .
    RefSeqi NP_633786.1. NC_003901.1.
    WP_011033702.1. NC_003901.1.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4HAC X-ray 1.92 A/B 1-301 [» ]
    ProteinModelPortali Q8PW39.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 192952.MM_1762.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    EnsemblBacteriai AAM31458 ; AAM31458 ; MM_1762 .
    GeneIDi 1480104.
    KEGGi mma:MM_1762.

    Phylogenomic databases

    eggNOGi COG1577.
    HOGENOMi HOG000080810.
    KOi K00869.
    OMAi AMAIKPR.

    Enzyme and pathway databases

    UniPathwayi UPA00057 ; UER00098 .
    BioCyci MetaCyc:MONOMER-18243.
    MMAZ192952:GCK2-1806-MONOMER.

    Family and domain databases

    Gene3Di 3.30.230.10. 1 hit.
    3.30.70.890. 1 hit.
    HAMAPi MF_00217. Mevalonate_kinase.
    InterProi IPR013750. GHMP_kinase_C_dom.
    IPR006204. GHMP_kinase_N_dom.
    IPR006203. GHMP_knse_ATP-bd_CS.
    IPR006205. Mev_gal_kin.
    IPR006206. Mevalonate/galactokinase.
    IPR022937. Mevalonate_kinase_arc.
    IPR020568. Ribosomal_S5_D2-typ_fold.
    IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
    [Graphical view ]
    PANTHERi PTHR10457:SF10. PTHR10457:SF10. 1 hit.
    Pfami PF08544. GHMP_kinases_C. 1 hit.
    PF00288. GHMP_kinases_N. 1 hit.
    [Graphical view ]
    PRINTSi PR00959. MEVGALKINASE.
    SUPFAMi SSF54211. SSF54211. 1 hit.
    SSF55060. SSF55060. 1 hit.
    TIGRFAMsi TIGR00549. mevalon_kin. 1 hit.
    PROSITEi PS00627. GHMP_KINASES_ATP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
      Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
      , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
      J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88Imported.
    2. "Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei."
      Zhuang N., Seo K.H., Chen C., Zhou J., Kim S.W., Lee K.H.
      Acta Crystallogr. F 68:1560-1563(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS).

    Entry informationi

    Entry nameiQ8PW39_METMA
    AccessioniPrimary (citable) accession number: Q8PW39
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    3D-structureImported, Complete proteome, Reference proteomeImported

    External Data

    Dasty 3