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Q8PW39 (Q8PW39_METMA) Unreviewed, UniProtKB/TrEMBL

Last modified April 16, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Third-party data text xml rdf/xml gff fasta
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Protein attributes

Sequence length301 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Catalytic activity

ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate. HAMAP-Rule MF_00217

Cofactor

Magnesium By similarity. HAMAP-Rule MF_00217

Subunit structure

Homodimer By similarity. HAMAP-Rule MF_00217

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00217.

Sequence similarities

Belongs to the GHMP kinase family. Mevalonate kinase subfamily. HAMAP-Rule MF_00217

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Regions

Nucleotide binding87 – 9711ATP By similarity HAMAP-Rule MF_00217

Sequences

Sequence LengthMass (Da)Tools
Q8PW39 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: CF223C2CE893D62D

FASTA30131,412
        10         20         30         40         50         60 
MVSCSAPGKI YLFGEHAVVY GETAIACAVE LRTRVRAELN DSITIQSQIG RTGLDFEKHP 

        70         80         90        100        110        120 
YVSAVIEKMR KSIPINGVFL TVDSDIPVGS GLGSSAAVTI ASIGALNELF GFGLSLQEIA 

       130        140        150        160        170        180 
KLGHEIEIKV QGAASPTDTY VSTFGGVVTI PERRKLKTPD CGIVIGDTGV FSSTKELVAN 

       190        200        210        220        230        240 
VRQLRESYPD LIEPLMTSIG KISRIGEQLV LSGDYASIGR LMNVNQGLLD ALGVNILELS 

       250        260        270        280        290        300 
QLIYSARAAG AFGAKITGAG GGGCMVALTA PEKCNQVAEA VAGAGGKVTI TKPTEQGLKV 


D 

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References

« Hide 'large scale' references
[1]"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baumer S., Jacobi C., Bruggemann H., Lienard T., Christmann A., Bomeke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. expand/collapse author list , Klenk H.P., Gunsalus R.P., Fritz H.J., Gottschalk G.
J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.
[2]"Crystallization and preliminary X-ray diffraction analysis of mevalonate kinase from Methanosarcina mazei."
Zhuang N., Seo K.H., Chen C., Zhou J., Kim S.W., Lee K.H.
Acta Crystallogr. F 68:1560-1563(2012) [PubMed] [Europe PMC] [Abstract]
Cited for: X-RAY CRYSTALLOGRAPHY (1.92 ANGSTROMS).

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008384 Genomic DNA. Translation: AAM31458.1.
RefSeqNP_633786.1. NC_003901.1.

3D structure databases

PDBe
RCSB PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
4HACX-ray1.92A/B1-301[»]
ProteinModelPortalQ8PW39.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING192952.MM_1762.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM31458; AAM31458; MM_1762.
GeneID1480104.
KEGGmma:MM_1762.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1577.
HOGENOMHOG000080810.
KOK00869.
OMAVEGDDCR.
ProtClustDBPRK03926.

Enzyme and pathway databases

BioCycMetaCyc:MONOMER-18243.
MMAZ192952:GCK2-1806-MONOMER.

Family and domain databases

Gene3D3.30.230.10. 1 hit.
3.30.70.890. 1 hit.
HAMAPMF_00217. Mevalonate_kinase.
InterProIPR013750. GHMP_kinase_C_dom.
IPR006204. GHMP_kinase_N_dom.
IPR006203. GHMP_knse_ATP-bd_CS.
IPR006205. Mev_gal_kin.
IPR006206. Mevalonate/galactokinase.
IPR022937. Mevalonate_kinase_arc.
IPR020568. Ribosomal_S5_D2-typ_fold.
IPR014721. Ribosomal_S5_D2-typ_fold_subgr.
[Graphical view]
PfamPF08544. GHMP_kinases_C. 1 hit.
PF00288. GHMP_kinases_N. 1 hit.
[Graphical view]
PRINTSPR00959. MEVGALKINASE.
SUPFAMSSF54211. SSF54211. 1 hit.
SSF55060. SSF55060. 1 hit.
TIGRFAMsTIGR00549. mevalon_kin. 1 hit.
PROSITEPS00627. GHMP_KINASES_ATP. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameQ8PW39_METMA
AccessionPrimary (citable) accession number: Q8PW39
Entry history
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusUnreviewed (UniProtKB/TrEMBL)