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Protein

Malate dehydrogenase

Gene

mdh

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

Catalyzes the reversible oxidation of malate to oxaloacetate.By similarity

Catalytic activityi

(S)-malate + NAD+ = oxaloacetate + NADH.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei32NADBy similarity1
Binding sitei81SubstrateBy similarity1
Binding sitei87SubstrateBy similarity1
Binding sitei94NADBy similarity1
Binding sitei119SubstrateBy similarity1
Binding sitei150SubstrateBy similarity1
Active sitei174Proton acceptorBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi8 – 13NADBy similarity6
Nucleotide bindingi117 – 119NADBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processTricarboxylic acid cycle
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Malate dehydrogenaseBy similarity (EC:1.1.1.37By similarity)
Gene namesi
Name:mdh
Ordered Locus Names:MM_1966
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001134871 – 307Malate dehydrogenaseAdd BLAST307

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_1966.

Structurei

3D structure databases

ProteinModelPortaliQ8PVJ7.
SMRiQ8PVJ7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the LDH/MDH superfamily.Curated

Phylogenomic databases

eggNOGiarCOG00246. Archaea.
COG0039. LUCA.
HOGENOMiHOG000213794.
KOiK00024.
OMAiMDLMQTA.
OrthoDBiPOG093Z062E.

Family and domain databases

CDDicd01339. LDH-like_MDH. 1 hit.
Gene3Di3.90.110.10. 1 hit.
HAMAPiMF_00487. Malate_dehydrog_3. 1 hit.
InterProiView protein in InterPro
IPR001557. L-lactate/malate_DH.
IPR022383. Lactate/malate_DH_C.
IPR001236. Lactate/malate_DH_N.
IPR015955. Lactate_DH/Glyco_Ohase_4_C.
IPR011275. Malate_DH_type3.
IPR036291. NAD(P)-bd_dom_sf.
PfamiView protein in Pfam
PF02866. Ldh_1_C. 1 hit.
PF00056. Ldh_1_N. 1 hit.
PIRSFiPIRSF000102. Lac_mal_DH. 1 hit.
PRINTSiPR00086. LLDHDRGNASE.
SUPFAMiSSF51735. SSF51735. 1 hit.
SSF56327. SSF56327. 1 hit.
TIGRFAMsiTIGR01763. MalateDH_bact. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PVJ7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVKISVIGAG NVGSTTVQRL AELEPGEIVM TDIVEGMPQG KALDLMQAGA
60 70 80 90 100
INGYDTRITG TNDYADIANS DLVIITAGIA RKPGMSREDL IKTNSKIIGD
110 120 130 140 150
VAGNIAKYAP NSIVINVTNP LDIITYVAMK ATGFDPEKVF GMSGVLDAGR
160 170 180 190 200
FASFIAEELK CSKRDVEAMV IGGHGDLMVP LPQYTTVSGI PLPELLPEKT
210 220 230 240 250
IDRLVERTVN GGAEIVELLK QGSAFYAPSA AIVRMAEAVI KDSRRVLPAS
260 270 280 290 300
AYLEGQYGQK GIYFGVPVKL GANGIEEILE LKLEDSQCEI LKKSSETIRK

GISKLEI
Length:307
Mass (Da):32,786
Last modified:October 1, 2002 - v1
Checksum:i93C68177714AF6D3
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31662.1.
RefSeqiWP_011033898.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM31662; AAM31662; MM_1966.
GeneIDi24878704.
KEGGimma:MM_1966.
PATRICifig|192952.21.peg.2265.

Similar proteinsi

Entry informationi

Entry nameiMDH_METMA
AccessioniPrimary (citable) accession number: Q8PVJ7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 101 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families