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Protein

DNA-directed RNA polymerase subunit H

Gene

rpoH

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Protein inferred from homologyi

Functioni

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.UniRule annotation

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, Transferase
Biological processTranscription

Names & Taxonomyi

Protein namesi
Recommended name:
DNA-directed RNA polymerase subunit HUniRule annotation (EC:2.7.7.6UniRule annotation)
Gene namesi
Name:rpoHUniRule annotation
Ordered Locus Names:MM_2274
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

Subcellular locationi

Keywords - Cellular componenti

DNA-directed RNA polymerase

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001460941 – 78DNA-directed RNA polymerase subunit HAdd BLAST78

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_2274.

Structurei

3D structure databases

ProteinModelPortaliQ8PUQ8.
SMRiQ8PUQ8.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the archaeal RpoH/eukaryotic RPB5 RNA polymerase subunit family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG04258. Archaea.
COG2012. LUCA.
HOGENOMiHOG000109413.
KOiK03053.
OMAiPKIYHDD.
OrthoDBiPOG093Z0M57.

Family and domain databases

Gene3Di3.90.940.20. 1 hit.
HAMAPiMF_00025. RNApol_RpoH_RPB5. 1 hit.
InterProiView protein in InterPro
IPR000783. RNA_pol_subH/Rpb5_C.
IPR020608. RNA_pol_subH/Rpb5_CS.
IPR020609. RpoH/RPB5.
PfamiView protein in Pfam
PF01191. RNA_pol_Rpb5_C. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005155. RNA_pol_subH/Rpb5_C. 1 hit.
SUPFAMiSSF55287. SSF55287. 1 hit.
PROSITEiView protein in PROSITE
PS01110. RNA_POL_H_23KD. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PUQ8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTKFSLLDHE AVPKHEIMSE GELKSVLSKY FIEKEQLPKI KVQDPVCKEI
60 70
GAVVGDVVKI TRKSQTAGEA DYYRLVIE
Length:78
Mass (Da):8,835
Last modified:October 10, 2002 - v1
Checksum:i3C1891AE088C1934
GO

Sequence cautioni

The sequence AAM31970 differs from that shown. Reason: Erroneous initiation.Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31970.1. Different initiation.
RefSeqiWP_048037333.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM31970; AAM31970; MM_2274.
GeneIDi24881980.
KEGGimma:MM_2274.
PATRICifig|192952.21.peg.2604.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA. Translation: AAM31970.1. Different initiation.
RefSeqiWP_048037333.1. NC_003901.1.

3D structure databases

ProteinModelPortaliQ8PUQ8.
SMRiQ8PUQ8.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi192952.MM_2274.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM31970; AAM31970; MM_2274.
GeneIDi24881980.
KEGGimma:MM_2274.
PATRICifig|192952.21.peg.2604.

Phylogenomic databases

eggNOGiarCOG04258. Archaea.
COG2012. LUCA.
HOGENOMiHOG000109413.
KOiK03053.
OMAiPKIYHDD.
OrthoDBiPOG093Z0M57.

Family and domain databases

Gene3Di3.90.940.20. 1 hit.
HAMAPiMF_00025. RNApol_RpoH_RPB5. 1 hit.
InterProiView protein in InterPro
IPR000783. RNA_pol_subH/Rpb5_C.
IPR020608. RNA_pol_subH/Rpb5_CS.
IPR020609. RpoH/RPB5.
PfamiView protein in Pfam
PF01191. RNA_pol_Rpb5_C. 1 hit.
ProDomiView protein in ProDom or Entries sharing at least one domain
PD005155. RNA_pol_subH/Rpb5_C. 1 hit.
SUPFAMiSSF55287. SSF55287. 1 hit.
PROSITEiView protein in PROSITE
PS01110. RNA_POL_H_23KD. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiRPOH_METMA
AccessioniPrimary (citable) accession number: Q8PUQ8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: June 7, 2017
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.