ID   MCH_METMA               Reviewed;         321 AA.
AC   Q8PTR0;
DT   10-OCT-2002, integrated into UniProtKB/Swiss-Prot.
DT   10-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 47.
DE   RecName: Full=Methenyltetrahydromethanopterin cyclohydrolase;
DE            EC=3.5.4.27;
DE   AltName: Full=Methenyl-H4MPT cyclohydrolase;
GN   Name=mch; OrderedLocusNames=MM_2653;
OS   Methanosarcina mazei (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=2209;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
RX   MEDLINE=22120827; PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene
RT   transfer between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- FUNCTION: Catalyzes the reversible interconversion of 5-formyl-
CC       H(4)MPT to methenyl-H(4)MPT(+) (By similarity).
CC   -!- CATALYTIC ACTIVITY: 5,10-methenyl-5,6,7,8-tetrahydromethanopterin
CC       + H(2)O = 5-formyl-5,6,7,8-tetrahydromethanopterin.
CC   -!- PATHWAY: One-carbon metabolism; methanogenesis from carbone
CC       dioxide; 5,10-methenyl-H(4)MPT from CO(2): step 3/3.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the MCH family.
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DR   EMBL; AE008384; AAM32349.1; -; Genomic_DNA.
DR   RefSeq; NP_634677.1; -.
DR   HSSP; P94954; 1QLM.
DR   GeneID; 1480995; -.
DR   GenomeReviews; AE008384_GR; MM_2653.
DR   KEGG; mma:MM_2653; -.
DR   NMPDR; fig|192952.1.peg.2653; -.
DR   HOGENOM; Q8PTR0; -.
DR   OMA; Q8PTR0; YFAMGSG.
DR   BioCyc; MMAZ192952:MM2653-MON; -.
DR   BRENDA; 3.5.4.27; 261165.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0018759; F:methenyltetrahydromethanopterin cyclohydrol...; IEA:HAMAP.
DR   GO; GO:0015948; P:methanogenesis; IEA:UniProtKB-KW.
DR   HAMAP; MF_00486; -; 1.
DR   InterPro; IPR003209; METHMP_CycHdrlase.
DR   Pfam; PF02289; MCH; 1.
DR   ProDom; PD011637; Cyclohydrolase; 1.
DR   TIGRFAMs; TIGR03120; one_C_mch; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Cytoplasm; Hydrolase; Methanogenesis;
KW   One-carbon metabolism.
FT   CHAIN         1    321       Methenyltetrahydromethanopterin
FT                                cyclohydrolase.
FT                                /FTId=PRO_0000140883.
SQ   SEQUENCE   321 AA;  34982 MW;  E52D1A7D169FAA8E CRC64;
     MISVNEMGSY VIEEMLDWSE DLKTEVIKLE NGATIIDCGI KAEGGYEAGM YLARLCLADL
     ADLKYSTFDL NGIKWPAIQV ATDNPVIACM ASQYAGWRIS VGNYFGMGSG PARALGLKPK
     ELYEEIGYED DFEAAVLVME SDKLPDEKVV EYIAKHCSVD PENVMIAVAP TASIAGSVQI
     SARVVETGIH KFESIGFDIN CIKSGYGIAP IAPIVGNDVQ CMGSTNDCVI YCGETNYTVS
     FEGELAKLED FVRKVPSTTS DDFGKPFYQT FKAANFDFFK VDAGMFAPAR VTVNDLKNKK
     TISSGGLYPE ILLESFGIRK V
//