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Q8PTK1

- DNLI2_METMA

UniProt

Q8PTK1 - DNLI2_METMA

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Protein

DNA ligase 2

Gene
lig2, MM_2714
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 3 out of 5 - Protein inferred from homologyi

Functioni

DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair By similarity.UniRule annotation

Catalytic activityi

ATP + (deoxyribonucleotide)(n) + (deoxyribonucleotide)(m) = AMP + diphosphate + (deoxyribonucleotide)(n+m).UniRule annotation

Cofactori

Divalent metal cations By similarity.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei254 – 2541ATP By similarity
Active sitei256 – 2561N6-AMP-lysine intermediate By similarity
Binding sitei261 – 2611ATP By similarity
Binding sitei276 – 2761ATP By similarity
Binding sitei306 – 3061ATP By similarity
Binding sitei346 – 3461ATP By similarity
Binding sitei425 – 4251ATP By similarity
Binding sitei431 – 4311ATP By similarity

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-HAMAP
  2. DNA binding Source: InterPro
  3. DNA ligase (ATP) activity Source: UniProtKB-HAMAP
  4. metal ion binding Source: UniProtKB-KW

GO - Biological processi

  1. cell cycle Source: UniProtKB-KW
  2. cell division Source: UniProtKB-KW
  3. DNA ligation involved in DNA repair Source: InterPro
  4. DNA recombination Source: UniProtKB-HAMAP
  5. DNA replication Source: UniProtKB-HAMAP
Complete GO annotation...

Keywords - Molecular functioni

Ligase

Keywords - Biological processi

Cell cycle, Cell division, DNA damage, DNA recombination, DNA repair, DNA replication

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-2775-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
DNA ligase 2 (EC:6.5.1.1)
Alternative name(s):
Polydeoxyribonucleotide synthase [ATP] 2
Gene namesi
Name:lig2
Ordered Locus Names:MM_2714
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000000595: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 568568DNA ligase 2UniRule annotationPRO_0000059606Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_2714.

Structurei

3D structure databases

ProteinModelPortaliQ8PTK1.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1793.
HOGENOMiHOG000036008.
KOiK10747.
OMAiARVQVHK.

Family and domain databases

Gene3Di1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPiMF_00407. DNA_ligase.
InterProiIPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view]
PfamiPF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view]
SUPFAMiSSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsiTIGR00574. dnl1. 1 hit.
PROSITEiPS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8PTK1-1 [UniParc]FASTAAdd to Basket

« Hide

MTSFREFAET CQAIEKISST IETTNKVADL LKKVDVEELP VATHFIMSEV    50
FPAWSGEQLG IGTSLLYVSL SKASGMSIHS IESLVRTTGD IGDTALLILK 100
EKRKNQVTFS SFFEEKPELS ITEVYRRFKI ASEASGKGSQ DIKVKNLQFL 150
FTSSSPREAK YISRLALEEL RIGVGEGVVR DAIAKAFSVP AEIVEHSFMV 200
TNDLGIVAAA AKKGGVEALE RLGIEINRPI KMMLSQISPD IDADIRAMKE 250
VAIEWKFDGA RVQIHKDGNS VTLFSRKLEN VTSSLPDLVE IVRKHVKAES 300
AILDGEAVAV DENGVPRAFQ EILKRFRRKY DVREKALGIP IQLNFFDIMY 350
INGKTLIDLP LLERRKALES CVESSVEDSK SISVAEQVIT GDLELVEKIY 400
REALKAGHEG VMVKNPNSVY SPGKRGKNWL KKKPLMDTLD LVIVGAEWGF 450
GRRANLIGSY TVACYDPDTT RFLQVGKVGT GLTDDQLKEL TEILSGLMEG 500
GEAGGVFAIR PKVVLEIAFE EIQKSPNYDS GFALRFPRFI RIRDDKDPEE 550
ADTIQRIGRV YSQQLKRL 568
Length:568
Mass (Da):63,185
Last modified:October 10, 2002 - v1
Checksum:iD98B7C62AD2B6751
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM32410.1.
RefSeqiNP_634738.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM32410; AAM32410; MM_2714.
GeneIDi1481056.
KEGGimma:MM_2714.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM32410.1 .
RefSeqi NP_634738.1. NC_003901.1.

3D structure databases

ProteinModelPortali Q8PTK1.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192952.MM_2714.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM32410 ; AAM32410 ; MM_2714 .
GeneIDi 1481056.
KEGGi mma:MM_2714.

Phylogenomic databases

eggNOGi COG1793.
HOGENOMi HOG000036008.
KOi K10747.
OMAi ARVQVHK.

Enzyme and pathway databases

BioCyci MMAZ192952:GCK2-2775-MONOMER.

Family and domain databases

Gene3Di 1.10.3260.10. 1 hit.
2.40.50.140. 1 hit.
HAMAPi MF_00407. DNA_ligase.
InterProi IPR022865. DNA_ligae_ATP-dep_bac/arc.
IPR000977. DNA_ligase_ATP-dep.
IPR012309. DNA_ligase_ATP-dep_C.
IPR012310. DNA_ligase_ATP-dep_cent.
IPR016059. DNA_ligase_ATP-dep_CS.
IPR012308. DNA_ligase_ATP-dep_N.
IPR012340. NA-bd_OB-fold.
[Graphical view ]
Pfami PF04679. DNA_ligase_A_C. 1 hit.
PF01068. DNA_ligase_A_M. 1 hit.
PF04675. DNA_ligase_A_N. 1 hit.
[Graphical view ]
SUPFAMi SSF117018. SSF117018. 1 hit.
SSF50249. SSF50249. 1 hit.
TIGRFAMsi TIGR00574. dnl1. 1 hit.
PROSITEi PS00697. DNA_LIGASE_A1. 1 hit.
PS50160. DNA_LIGASE_A3. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
    Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
    , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Entry informationi

Entry nameiDNLI2_METMA
AccessioniPrimary (citable) accession number: Q8PTK1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: May 14, 2014
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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