ID   ADEC_METMA              Reviewed;         555 AA.
AC   Q8PT13;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 37.
DE   RecName: Full=Adenine deaminase;
DE            Short=Adenase;
DE            Short=Adenine aminase;
DE            EC=3.5.4.2;
GN   Name=ade; OrderedLocusNames=MM_2910;
OS   Methanosarcina mazei (Methanosarcina frisia).
OC   Archaea; Euryarchaeota; Methanomicrobia; Methanosarcinales;
OC   Methanosarcinaceae; Methanosarcina.
OX   NCBI_TaxID=2209;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88;
RX   MEDLINE=22120827; PubMed=12125824;
RA   Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A.,
RA   Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C.,
RA   Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S.,
RA   Bhattacharyya A., Lykidis A., Overbeek R., Klenk H.-P., Gunsalus R.P.,
RA   Fritz H.-J., Gottschalk G.;
RT   "The genome of Methanosarcina mazei: evidence for lateral gene
RT   transfer between Bacteria and Archaea.";
RL   J. Mol. Microbiol. Biotechnol. 4:453-461(2002).
CC   -!- CATALYTIC ACTIVITY: Adenine + H(2)O = hypoxanthine + NH(3).
CC   -!- COFACTOR: Manganese (By similarity).
CC   -!- SIMILARITY: Belongs to the adenine deaminase family.
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DR   EMBL; AE008384; AAM32606.1; -; Genomic_DNA.
DR   RefSeq; NP_634934.1; -.
DR   GeneID; 1481252; -.
DR   GenomeReviews; AE008384_GR; MM_2910.
DR   KEGG; mma:MM_2910; -.
DR   NMPDR; fig|192952.1.peg.2910; -.
DR   HOGENOM; Q8PT13; -.
DR   OMA; Q8PT13; PGKIITE.
DR   BioCyc; MMAZ192952:MM2910-MON; -.
DR   BRENDA; 3.5.4.2; 261165.
DR   GO; GO:0000034; F:adenine deaminase activity; IEA:HAMAP.
DR   GO; GO:0030145; F:manganese ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006146; P:adenine catabolic process; IEA:InterPro.
DR   HAMAP; MF_01518; -; 1.
DR   InterPro; IPR006679; Adenine_deam.
DR   InterPro; IPR006680; Amidohydro_1.
DR   Pfam; PF01979; Amidohydro_1; 1.
DR   TIGRFAMs; TIGR01178; ade; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Hydrolase; Manganese.
FT   CHAIN         1    555       Adenine deaminase.
FT                                /FTId=PRO_0000142442.
SQ   SEQUENCE   555 AA;  61369 MW;  12B85B52C53DF40F CRC64;
     MKKYMGIIVD AISRRQFKGE ITVENGKIIR VEEKEHDNEQ YILPGLVDAH VHIESSMTVP
     SVFARMAVAK GTVAVVSDPH EIANVMGEEG IEFMLEDSKK SPLKVYFGVP SCVPATPFES
     SGAVLDINAV DRLLAKDDLH YLSEMMNFPG VILEFPDVMA KLESARKHGK VIDGHAPGLR
     GADLQKYIGA GISTDHECFE YEEAREKIEL GMKILIREGS SARNFETLYP LIDEYPDHVM
     LCTDDSHPDT LIYEGHIDKL IRRGQEKGLD IYNLIRTAVF NPVEHYGLNV GLLREGDPAD
     FIIVDNLKSF NILSTFIDGE CVYENGKVLF PLEKVPAKNV FNRNKISIDD VKLVPPAGAI
     QEQTTEKGIK KIRVIVANDG ELVTGQELIV PKIENGNLVS DPERDILKMV VLSRYSDDPV
     RIGFIKNIGL EKGAIASSIA HDSHNIIAVG ATDEDIVETV NRLIKNKGGI AVGTAENLLD
     LPLEVAGLMS TLEGEEVASR YHLLNEEARK LGTSLESPFM TLAFMSLLVI PELKLGDKGL
     FDVTKFEFVD LFADE
//