Reviewed, UniProtKB/Swiss-Prot Q8PT13 (ADEC_METMA)

Names and origin

Protein names

Recommended name:
    Adenine deaminase
      Short name=Adenase
      Short name=Adenine aminase
    EC=3.5.4.2

Gene names

Name:	ade
Ordered Locus Names:	MM_2910

Organism

Methanosarcina mazei (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

2209 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	555 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518
Cofactor	Manganese By similarity.
Sequence similarities	Belongs to the adenine deaminase family.

Ontologies

Keywords
Ligand	Manganese
Molecular function	Hydrolase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	adenine catabolic process Inferred from electronic annotation. Source: InterPro
Molecular function	adenine deaminase activity Inferred from electronic annotation. Source: HAMAP manganese ion binding Inferred from electronic annotation. Source: UniProtKB-KW
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 555	555	Adenine deaminase HAMAP MF_01518		PRO_0000142442

Sequences

	Sequence		Length	Mass (Da)
	Q8PT13-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 12B85B52C53DF40F	FASTA	555	61,369
	10 20 30 40 50 60 MKKYMGIIVD AISRRQFKGE ITVENGKIIR VEEKEHDNEQ YILPGLVDAH VHIESSMTVP 70 80 90 100 110 120 SVFARMAVAK GTVAVVSDPH EIANVMGEEG IEFMLEDSKK SPLKVYFGVP SCVPATPFES 130 140 150 160 170 180 SGAVLDINAV DRLLAKDDLH YLSEMMNFPG VILEFPDVMA KLESARKHGK VIDGHAPGLR 190 200 210 220 230 240 GADLQKYIGA GISTDHECFE YEEAREKIEL GMKILIREGS SARNFETLYP LIDEYPDHVM 250 260 270 280 290 300 LCTDDSHPDT LIYEGHIDKL IRRGQEKGLD IYNLIRTAVF NPVEHYGLNV GLLREGDPAD 310 320 330 340 350 360 FIIVDNLKSF NILSTFIDGE CVYENGKVLF PLEKVPAKNV FNRNKISIDD VKLVPPAGAI 370 380 390 400 410 420 QEQTTEKGIK KIRVIVANDG ELVTGQELIV PKIENGNLVS DPERDILKMV VLSRYSDDPV 430 440 450 460 470 480 RIGFIKNIGL EKGAIASSIA HDSHNIIAVG ATDEDIVETV NRLIKNKGGI AVGTAENLLD 490 500 510 520 530 540 LPLEVAGLMS TLEGEEVASR YHLLNEEARK LGTSLESPFM TLAFMSLLVI PELKLGDKGL 550 FDVTKFEFVD LFADE

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008384 Genomic DNA. Translation: AAM32606.1.
RefSeq	NP_634934.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1481252.
GenomeReviews	Gene locus MM_2910 in contig AE008384_GR.
KEGG	mma:MM_2910.
NMPDR	fig|192952.1.peg.2910.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8PT13.
OMA	Q8PT13. PGKIITE.
Enzyme and pathway databases
BioCyc	MMAZ192952:MM2910-MON.
BRENDA	3.5.4.2. 261165.
Family and domain databases
HAMAP	MF_01518. [Tree]
InterPro	IPR006679. Adenine_deam. IPR006680. Amidohydro_1. [Graphical view]
Pfam	PF01979. Amidohydro_1. 1 hit. [Graphical view]
TIGRFAMs	TIGR01178. ade. 1 hit.
ProtoNet	Search...

Entry information

Entry name

ADEC_METMA

Accession

Primary (citable) accession number: Q8PT13

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 37 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)