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Q8PT13 (ADEC_METMA) Reviewed, UniProtKB/Swiss-Prot

Last modified December 14, 2011. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Adenine deaminase
Short name=Adenase
Short name=Adenine aminase
EC=3.5.4.2
Gene names
Name:ade
Ordered Locus Names:MM_2910
OrganismMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP]
Taxonomic identifier192952 [NCBI]
Taxonomic lineageArchaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length555 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Adenine + H2O = hypoxanthine + NH3. HAMAP MF_01518

Cofactor

Manganese By similarity. HAMAP MF_01518

Sequence similarities

Belongs to the adenine deaminase family.

Ontologies

Keywords
   LigandManganese
   Molecular functionHydrolase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processadenine catabolic process

Inferred from electronic annotation. Source: InterPro

   Molecular functionadenine deaminase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 555555Adenine deaminase HAMAP MF_01518
PRO_0000142442

Sequences

Sequence LengthMass (Da)Tools
Q8PT13 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 12B85B52C53DF40F

FASTA55561,369
        10         20         30         40         50         60 
MKKYMGIIVD AISRRQFKGE ITVENGKIIR VEEKEHDNEQ YILPGLVDAH VHIESSMTVP 

        70         80         90        100        110        120 
SVFARMAVAK GTVAVVSDPH EIANVMGEEG IEFMLEDSKK SPLKVYFGVP SCVPATPFES 

       130        140        150        160        170        180 
SGAVLDINAV DRLLAKDDLH YLSEMMNFPG VILEFPDVMA KLESARKHGK VIDGHAPGLR 

       190        200        210        220        230        240 
GADLQKYIGA GISTDHECFE YEEAREKIEL GMKILIREGS SARNFETLYP LIDEYPDHVM 

       250        260        270        280        290        300 
LCTDDSHPDT LIYEGHIDKL IRRGQEKGLD IYNLIRTAVF NPVEHYGLNV GLLREGDPAD 

       310        320        330        340        350        360 
FIIVDNLKSF NILSTFIDGE CVYENGKVLF PLEKVPAKNV FNRNKISIDD VKLVPPAGAI 

       370        380        390        400        410        420 
QEQTTEKGIK KIRVIVANDG ELVTGQELIV PKIENGNLVS DPERDILKMV VLSRYSDDPV 

       430        440        450        460        470        480 
RIGFIKNIGL EKGAIASSIA HDSHNIIAVG ATDEDIVETV NRLIKNKGGI AVGTAENLLD 

       490        500        510        520        530        540 
LPLEVAGLMS TLEGEEVASR YHLLNEEARK LGTSLESPFM TLAFMSLLVI PELKLGDKGL 

       550 
FDVTKFEFVD LFADE

« Hide

References

[1]"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. expand/collapse author list , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AE008384 Genomic DNA. Translation: AAM32606.1.
RefSeqNP_634934.1. NC_003901.1.

3D structure databases

ProteinModelPortalQ8PT13.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1481252.
GenomeReviewsGene locus MM_2910 in contig AE008384_GR.
KEGGmma:MM_2910.
NMPDRfig|192952.1.peg.2910.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG725357.
OMAGKIITEH.
PhylomeDBQ8PT13.
ProtClustDBCLSK2754571.

Enzyme and pathway databases

BioCycMMAZ192952:MM2910-MONOMER.

Family and domain databases

HAMAPMF_01518. Adenine_deamin.
[Tree]
InterProIPR006679. Adenine_deam.
IPR006680. Amidohydro_1.
IPR011059. Metal-dep_hydrolase_composite.
[Graphical view]
KOK01486.
PfamPF01979. Amidohydro_1. 1 hit.
[Graphical view]
SUPFAMSSF51338. Metalo_hydrolase. 1 hit.
TIGRFAMsTIGR01178. Ade. 1 hit.
ProtoNetSearch...

Entry information

Entry nameADEC_METMA
AccessionPrimary (citable) accession number: Q8PT13
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: December 14, 2011
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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