Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Nicotinate phosphoribosyltransferase

Gene

pncB

Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.UniRule annotation

Catalytic activityi

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate.UniRule annotation

Pathwayi: NAD(+) biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Nicotinate phosphoribosyltransferase (pncB)
This subpathway is part of the pathway NAD(+) biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes nicotinate D-ribonucleotide from nicotinate, the pathway NAD(+) biosynthesis and in Cofactor biosynthesis.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionLigase, Transferase
Biological processPyridine nucleotide biosynthesis

Enzyme and pathway databases

UniPathwayiUPA00253; UER00457

Names & Taxonomyi

Protein namesi
Recommended name:
Nicotinate phosphoribosyltransferaseUniRule annotation (EC:6.3.4.21UniRule annotation)
Short name:
NAPRTaseUniRule annotation
Gene namesi
Name:pncBUniRule annotation
Ordered Locus Names:MM_3086
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
Proteomesi
  • UP000000595 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002058581 – 406Nicotinate phosphoribosyltransferaseAdd BLAST406

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_3086

Structurei

3D structure databases

ProteinModelPortaliQ8PSJ3
SMRiQ8PSJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NAPRTase family.UniRule annotation

Phylogenomic databases

eggNOGiarCOG01481 Archaea
COG1488 LUCA
HOGENOMiHOG000284928
KOiK00763
OMAiKLTMQCA
OrthoDBiPOG093Z04JA

Family and domain databases

CDDicd01401 PncB_like, 1 hit
HAMAPiMF_00570 NAPRTase, 1 hit
InterProiView protein in InterPro
IPR006406 Nic_PRibTrfase
IPR007229 Nic_PRibTrfase-Fam
IPR036068 Nicotinate_pribotase_like_C
PANTHERiPTHR11098 PTHR11098, 1 hit
PfamiView protein in Pfam
PF04095 NAPRTase, 1 hit
PIRSFiPIRSF000484 NAPRT, 1 hit
SUPFAMiSSF51690 SSF51690, 2 hits
TIGRFAMsiTIGR01514 NAPRTase, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PSJ3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIKSILDNDL YKFTMQMAVL ELFPKAEAEY RFTNRGLQRF SREFVEELRR
60 70 80 90 100
VIDEEISGLR LTEEEYRWLG EKCPFLKPMY LEYLKNFRFK PEEVEICLTR
110 120 130 140 150
ENDLDMRIKG PWHSTILWEI VLMAAVSELY FTTIEKEWNG STKNPGTPES
160 170 180 190 200
ATLESVLEAY GEKILEIGKV LEENGCLFSE FGTRRRRSFE LHDQVMRSLV
210 220 230 240 250
RIKTLTGTSN VYFAKKYGVK PIGTVGHEWI MGTSALVGLR YANRFAFENW
260 270 280 290 300
VDVYNGDLGI ALTDTFGSEA FFKDMDLKLS KIYDGFRHDS GDPYTFVDRV
310 320 330 340 350
IEHYGKMGID PMKKVIVFSD ALNAEAAVKL KKYCEGKINC SFGIGTSLTN
360 370 380 390 400
NSEFFRESPP LNMVIKLHSI NGIPVVKLSD SPEKETGERD ALRVANYIVG

RKGLDE
Length:406
Mass (Da):46,660
Last modified:October 10, 2002 - v1
Checksum:iF2452FDFB302ECDE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008384 Genomic DNA Translation: AAM32782.1
RefSeqiWP_011034984.1, NC_003901.1

Genome annotation databases

EnsemblBacteriaiAAM32782; AAM32782; MM_3086
GeneIDi24882961
KEGGimma:MM_3086
PATRICifig|192952.21.peg.3580

Similar proteinsi

Entry informationi

Entry nameiPNCB_METMA
AccessioniPrimary (citable) accession number: Q8PSJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: April 25, 2018
This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health