Reviewed, UniProtKB/Swiss-Prot Q8PSJ3 (PNCB_METMA)

Names and origin

Protein names

Recommended name:
    Nicotinate phosphoribosyltransferase
      Short name=NAPRTase
    EC=2.4.2.11

Gene names

Name:	pncB
Ordered Locus Names:	MM_3086

Organism

Methanosarcina mazei (Methanosarcina frisia) [Complete proteome] [HAMAP]

Taxonomic identifier

2209 [NCBI]

Taxonomic lineage

Archaea › Euryarchaeota › Methanomicrobia › Methanosarcinales › Methanosarcinaceae › Methanosarcina

Protein attributes

Sequence length	406 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate. HAMAP MF_00570
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP MF_00570
Subcellular location	Cytoplasm By similarity.
Sequence similarities	Belongs to the NAPRTase family.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Cellular component	Cytoplasm
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	NAD biosynthetic process Inferred from electronic annotation. Source: HAMAP nicotinate nucleotide biosynthetic process Inferred from electronic annotation. Source: InterPro
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	nicotinate phosphoribosyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 406	406	Nicotinate phosphoribosyltransferase HAMAP MF_00570		PRO_0000205858

Sequences

	Sequence		Length	Mass (Da)
	Q8PSJ3-1 [UniParc]. Last modified October 10, 2002. Version 1. Checksum: F2452FDFB302ECDE	FASTA	406	46,660
	10 20 30 40 50 60 MIKSILDNDL YKFTMQMAVL ELFPKAEAEY RFTNRGLQRF SREFVEELRR VIDEEISGLR 70 80 90 100 110 120 LTEEEYRWLG EKCPFLKPMY LEYLKNFRFK PEEVEICLTR ENDLDMRIKG PWHSTILWEI 130 140 150 160 170 180 VLMAAVSELY FTTIEKEWNG STKNPGTPES ATLESVLEAY GEKILEIGKV LEENGCLFSE 190 200 210 220 230 240 FGTRRRRSFE LHDQVMRSLV RIKTLTGTSN VYFAKKYGVK PIGTVGHEWI MGTSALVGLR 250 260 270 280 290 300 YANRFAFENW VDVYNGDLGI ALTDTFGSEA FFKDMDLKLS KIYDGFRHDS GDPYTFVDRV 310 320 330 340 350 360 IEHYGKMGID PMKKVIVFSD ALNAEAAVKL KKYCEGKINC SFGIGTSLTN NSEFFRESPP 370 380 390 400 LNMVIKLHSI NGIPVVKLSD SPEKETGERD ALRVANYIVG RKGLDE

References

[1]

"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea." Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G. J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed: 12125824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11883 / OCM 88.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008384 Genomic DNA. Translation: AAM32782.1.
RefSeq	NP_635110.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1481428.
GenomeReviews	Gene locus MM_3086 in contig AE008384_GR.
KEGG	mma:MM_3086.
NMPDR	fig|192952.1.peg.3086.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8PSJ3.
OMA	ALTDTFG.
Enzyme and pathway databases
BioCyc	MMAZ192952:MM3086-MON.
BRENDA	2.4.2.11. 261165.
Family and domain databases
HAMAP	MF_00570. [Tree]
InterPro	IPR006406. Nic_PRibTrfase. IPR015977. Nic_PRibTrfase-like. IPR007229. Nic_PRibTrfase-rel. [Graphical view]
PANTHER	PTHR11098:SF1. NAPRTase. 1 hit.
Pfam	PF04095. NAPRTase. 1 hit. [Graphical view]
PIRSF	PIRSF000484. NAPRT. 1 hit.
TIGRFAMs	TIGR01514. NAPRTase. 1 hit.
ProtoNet	Search...

Entry information

Entry name

PNCB_METMA

Accession

Primary (citable) accession number: Q8PSJ3

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 10, 2002
Last modified:	November 3, 2009
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)