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Q8PSJ3 (PNCB_METMA) Reviewed, UniProtKB/Swiss-Prot

Last modified June 11, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Nicotinate phosphoribosyltransferase

Short name=NAPRTase
EC=6.3.4.21
Gene names
Name:pncB
Ordered Locus Names:MM_3086
OrganismMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia) [Complete proteome] [HAMAP]
Taxonomic identifier192952 [NCBI]
Taxonomic lineageArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina

Protein attributes

Sequence length406 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP By similarity. HAMAP-Rule MF_00570

Catalytic activity

Nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = beta-nicotinate D-ribonucleotide + diphosphate + ADP + phosphate. HAMAP-Rule MF_00570

Pathway

Cofactor biosynthesis; NAD(+) biosynthesis; nicotinate D-ribonucleotide from nicotinate: step 1/1. HAMAP-Rule MF_00570

Sequence similarities

Belongs to the NAPRTase family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 406406Nicotinate phosphoribosyltransferase HAMAP-Rule MF_00570
PRO_0000205858

Sequences

Sequence LengthMass (Da)Tools
Q8PSJ3 [UniParc].

Last modified October 10, 2002. Version 1.
Checksum: F2452FDFB302ECDE

FASTA40646,660
        10         20         30         40         50         60 
MIKSILDNDL YKFTMQMAVL ELFPKAEAEY RFTNRGLQRF SREFVEELRR VIDEEISGLR 

        70         80         90        100        110        120 
LTEEEYRWLG EKCPFLKPMY LEYLKNFRFK PEEVEICLTR ENDLDMRIKG PWHSTILWEI 

       130        140        150        160        170        180 
VLMAAVSELY FTTIEKEWNG STKNPGTPES ATLESVLEAY GEKILEIGKV LEENGCLFSE 

       190        200        210        220        230        240 
FGTRRRRSFE LHDQVMRSLV RIKTLTGTSN VYFAKKYGVK PIGTVGHEWI MGTSALVGLR 

       250        260        270        280        290        300 
YANRFAFENW VDVYNGDLGI ALTDTFGSEA FFKDMDLKLS KIYDGFRHDS GDPYTFVDRV 

       310        320        330        340        350        360 
IEHYGKMGID PMKKVIVFSD ALNAEAAVKL KKYCEGKINC SFGIGTSLTN NSEFFRESPP 

       370        380        390        400 
LNMVIKLHSI NGIPVVKLSD SPEKETGERD ALRVANYIVG RKGLDE 

« Hide

References

[1]"The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R. expand/collapse author list , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008384 Genomic DNA. Translation: AAM32782.1.
RefSeqNP_635110.1. NC_003901.1.

3D structure databases

ProteinModelPortalQ8PSJ3.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING192952.MM_3086.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM32782; AAM32782; MM_3086.
GeneID1481428.
KEGGmma:MM_3086.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1488.
HOGENOMHOG000284928.
KOK00763.
OMAQAVFHRY.

Enzyme and pathway databases

BioCycMMAZ192952:GCK2-3151-MONOMER.
UniPathwayUPA00253; UER00457.

Family and domain databases

HAMAPMF_00570. NAPRTase.
InterProIPR006406. Nic_PRibTrfase.
IPR007229. Nic_PRibTrfase-Fam.
IPR002638. Quinolinate_PRibosylTrfase_C.
[Graphical view]
PfamPF04095. NAPRTase. 1 hit.
[Graphical view]
PIRSFPIRSF000484. NAPRT. 1 hit.
SUPFAMSSF51690. SSF51690. 2 hits.
TIGRFAMsTIGR01514. NAPRTase. 1 hit.
ProtoNetSearch...

Entry information

Entry namePNCB_METMA
AccessionPrimary (citable) accession number: Q8PSJ3
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: June 11, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways