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Q8PS70

- CAPPA_METMA

UniProt

Q8PS70 - CAPPA_METMA

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Protein
Phosphoenolpyruvate carboxylase
Gene
ppcA, MM_3212
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle By similarity.UniRule annotation

Catalytic activityi

Phosphate + oxaloacetate = H2O + phosphoenolpyruvate + HCO3-.UniRule annotation

Cofactori

Magnesium By similarity.UniRule annotation

GO - Molecular functioni

  1. magnesium ion binding Source: UniProtKB-HAMAP
  2. phosphoenolpyruvate carboxylase activity Source: UniProtKB-HAMAP

GO - Biological processi

  1. carbon fixation Source: UniProtKB-HAMAP
  2. oxaloacetate metabolic process Source: UniProtKB-HAMAP
  3. tricarboxylic acid cycle Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Lyase

Keywords - Biological processi

Carbon dioxide fixation

Keywords - Ligandi

Magnesium

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-3277-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Phosphoenolpyruvate carboxylase (EC:4.1.1.31)
Short name:
PEPC
Short name:
PEPCase
Gene namesi
Name:ppcA
Ordered Locus Names:MM_3212
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000000595: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 526526Phosphoenolpyruvate carboxylaseUniRule annotation
PRO_0000309604Add
BLAST

Interactioni

Subunit structurei

Homotetramer By similarity.UniRule annotation

Protein-protein interaction databases

STRINGi192952.MM_3212.

Structurei

3D structure databases

ProteinModelPortaliQ8PS70.

Family & Domainsi

Sequence similaritiesi

Belongs to the PEPCase type 2 family.

Phylogenomic databases

eggNOGiCOG1892.
HOGENOMiHOG000009826.
KOiK01595.
OMAiDEYMPDY.

Family and domain databases

HAMAPiMF_01904. PEPcase_type2.
InterProiIPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view]
PfamiPF14010. PEPcase_2. 1 hit.
[Graphical view]
PIRSFiPIRSF006677. UCP006677. 1 hit.
SUPFAMiSSF51621. SSF51621. 1 hit.
TIGRFAMsiTIGR02751. PEPCase_arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PS70-1 [UniParc]FASTAAdd to Basket

« Hide

MSKKATYPKV MCTQHPDSAS KYISTQEEPG EAIEAAVVFG CDEYMPDYEG    50
KATPYHQNVQ IVSRFIEETD LIPGKDIFIT PRAPSAAQEN RFRQLMVMMS 100
IAEANHGALE YSDVQAINEF VHPMTGTVGE ILDAQQHMVD VGELAKKEFG 150
VAMEVPRIIP LIEDAPALLH AKELAENTLL SWEKRFGAAP EKFRVFLGKS 200
DSALSFGHVA STLSCKYAIS GISELDLELD TSTGIIFGAG TLPFRGHLSL 250
KNAENFFREY RGIGTITLQS AVRYSHDKGE AEALVRLAEE RLPESPEIYS 300
GEEKEEIVNL IGIFGARYNR IIREMSCTIN QLAGLLPQQR DRLMHKGTGG 350
YSRNVPDISG LVCLCRKDVG KELSASMPAE DLNLPRAIKF TGALYSIGLP 400
PEFIGTGTAL EEAREKLGEE ACERLLKKYF PSLASDLSFA SGYLDLNVAS 450
RFLPEACLKE IRKDIEVLRD TFSLKVQPEP SYRILLEMMQ PDLLQAGTKG 500
NCMDEEVSQL VCSTLTKMGK IRKALG 526
Length:526
Mass (Da):58,177
Last modified:October 1, 2002 - v1
Checksum:i7CCCE37156EF8B55
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM32908.1.
RefSeqiNP_635236.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM32908; AAM32908; MM_3212.
GeneIDi1481554.
KEGGimma:MM_3212.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM32908.1 .
RefSeqi NP_635236.1. NC_003901.1.

3D structure databases

ProteinModelPortali Q8PS70.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192952.MM_3212.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM32908 ; AAM32908 ; MM_3212 .
GeneIDi 1481554.
KEGGi mma:MM_3212.

Phylogenomic databases

eggNOGi COG1892.
HOGENOMi HOG000009826.
KOi K01595.
OMAi DEYMPDY.

Enzyme and pathway databases

BioCyci MMAZ192952:GCK2-3277-MONOMER.

Family and domain databases

HAMAPi MF_01904. PEPcase_type2.
InterProi IPR007566. PEP_COase_arc-type.
IPR015813. Pyrv/PenolPyrv_Kinase-like_dom.
[Graphical view ]
Pfami PF14010. PEPcase_2. 1 hit.
[Graphical view ]
PIRSFi PIRSF006677. UCP006677. 1 hit.
SUPFAMi SSF51621. SSF51621. 1 hit.
TIGRFAMsi TIGR02751. PEPCase_arch. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
    Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
    , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Entry informationi

Entry nameiCAPPA_METMA
AccessioniPrimary (citable) accession number: Q8PS70
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 13, 2007
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 62 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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