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Q8PRX4

- TRPF2_METMA

UniProt

Q8PRX4 - TRPF2_METMA

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Protein
N-(5'-phosphoribosyl)anthranilate isomerase 2
Gene
trpF2, MM_3314
Organism
Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Status
Reviewed - Annotation score: 2 out of 5 - Protein inferred from homologyi

Functioni

Catalytic activityi

N-(5-phospho-beta-D-ribosyl)anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate.UniRule annotation

Pathwayi

GO - Molecular functioni

  1. phosphoribosylanthranilate isomerase activity Source: UniProtKB-EC

GO - Biological processi

  1. tryptophan biosynthetic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Isomerase

Keywords - Biological processi

Amino-acid biosynthesis, Aromatic amino acid biosynthesis, Tryptophan biosynthesis

Enzyme and pathway databases

BioCyciMMAZ192952:GCK2-3379-MONOMER.
UniPathwayiUPA00035; UER00042.

Names & Taxonomyi

Protein namesi
Recommended name:
N-(5'-phosphoribosyl)anthranilate isomerase 2 (EC:5.3.1.24)
Short name:
PRAI 2
Gene namesi
Name:trpF2
Ordered Locus Names:MM_3314
OrganismiMethanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88) (Methanosarcina frisia)
Taxonomic identifieri192952 [NCBI]
Taxonomic lineageiArchaeaEuryarchaeotaMethanomicrobiaMethanosarcinalesMethanosarcinaceaeMethanosarcina
ProteomesiUP000000595: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 226226N-(5'-phosphoribosyl)anthranilate isomerase 2UniRule annotation
PRO_0000154406Add
BLAST

Interactioni

Protein-protein interaction databases

STRINGi192952.MM_3314.

Structurei

3D structure databases

ProteinModelPortaliQ8PRX4.

Family & Domainsi

Sequence similaritiesi

Belongs to the TrpF family.

Phylogenomic databases

eggNOGiCOG0135.
HOGENOMiHOG000161598.
KOiK01817.
OMAiKICCISS.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
HAMAPiMF_00135. PRAI.
InterProiIPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view]
PfamiPF00697. PRAI. 1 hit.
[Graphical view]
SUPFAMiSSF51366. SSF51366. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PRX4-1 [UniParc]FASTAAdd to Basket

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MRIKVCGIKR VEDAVMAAYC GADAIGLVVG RKHNSDDFID KHLAQKIVRE    50
CPPYISPVLV TELDDAEEIS GLVHETGVTS VQLHSDCTVD SIISLRKTFP 100
NIKIIKNFHV IGPGVIHAMK PFESVVDAFI LDTLDLANDK VGSTGLVHDW 150
SISRKIVKEV SRPVILAGGL TPENVGEAIR VVNPYGVDAS SGLKDSNGFK 200
DEMKVINFVH RAKNDFFKVR NLSLEN 226
Length:226
Mass (Da):24,760
Last modified:March 25, 2003 - v2
Checksum:i1EE6D057BEA7536E
GO

Sequence cautioni

The sequence AAM33010.1 differs from that shown. Reason: Erroneous initiation.

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM33010.1. Different initiation.
RefSeqiNP_635338.1. NC_003901.1.

Genome annotation databases

EnsemblBacteriaiAAM33010; AAM33010; MM_3314.
GeneIDi1481656.
KEGGimma:MM_3314.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AE008384 Genomic DNA. Translation: AAM33010.1 . Different initiation.
RefSeqi NP_635338.1. NC_003901.1.

3D structure databases

ProteinModelPortali Q8PRX4.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 192952.MM_3314.

Protocols and materials databases

DNASUi 1481656.
Structural Biology Knowledgebase Search...

Genome annotation databases

EnsemblBacteriai AAM33010 ; AAM33010 ; MM_3314 .
GeneIDi 1481656.
KEGGi mma:MM_3314.

Phylogenomic databases

eggNOGi COG0135.
HOGENOMi HOG000161598.
KOi K01817.
OMAi KICCISS.

Enzyme and pathway databases

UniPathwayi UPA00035 ; UER00042 .
BioCyci MMAZ192952:GCK2-3379-MONOMER.

Family and domain databases

Gene3Di 3.20.20.70. 1 hit.
HAMAPi MF_00135. PRAI.
InterProi IPR013785. Aldolase_TIM.
IPR001240. PRAI_dom.
IPR011060. RibuloseP-bd_barrel.
[Graphical view ]
Pfami PF00697. PRAI. 1 hit.
[Graphical view ]
SUPFAMi SSF51366. SSF51366. 1 hit.
ProtoNeti Search...

Publicationsi

  1. "The genome of Methanosarcina mazei: evidence for lateral gene transfer between Bacteria and Archaea."
    Deppenmeier U., Johann A., Hartsch T., Merkl R., Schmitz R.A., Martinez-Arias R., Henne A., Wiezer A., Baeumer S., Jacobi C., Brueggemann H., Lienard T., Christmann A., Boemecke M., Steckel S., Bhattacharyya A., Lykidis A., Overbeek R.
    , Klenk H.-P., Gunsalus R.P., Fritz H.-J., Gottschalk G.
    J. Mol. Microbiol. Biotechnol. 4:453-461(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88.

Entry informationi

Entry nameiTRPF2_METMA
AccessioniPrimary (citable) accession number: Q8PRX4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: March 25, 2003
Last modified: May 14, 2014
This is version 70 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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