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Q8PQ74 (HGD_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homogentisate 1,2-dioxygenase

EC=1.13.11.5
Alternative name(s):
Homogentisate oxygenase
Homogentisic acid oxidase
Homogentisicase
Gene names
Name:hmgA
Ordered Locus Names:XAC0454
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length458 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

Homogentisate + O2 = 4-maleylacetoacetate. HAMAP-Rule MF_00334

Cofactor

Iron By similarity. HAMAP-Rule MF_00334

Pathway

Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP-Rule MF_00334

Sequence similarities

Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
   Biological processPhenylalanine catabolism
Tyrosine catabolism
   LigandIron
Metal-binding
   Molecular functionDioxygenase
Oxidoreductase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processL-phenylalanine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

tyrosine catabolic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Molecular_functionhomogentisate 1,2-dioxygenase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

iron ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 458458Homogentisate 1,2-dioxygenase HAMAP-Rule MF_00334
PRO_0000220257

Sites

Metal binding3511Iron By similarity
Metal binding3571Iron By similarity
Metal binding3871Iron By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PQ74 [UniParc].

Last modified October 10, 2002. Version 1.
Checksum: E2237A2256088FDD

FASTA45850,450
        10         20         30         40         50         60 
MIQRDPNLLL SWRADQHPDA PMHNDQRYMT GFGNEFATEA VAGSLPIGQN SPQRVAHGLY 

        70         80         90        100        110        120 
AEQLSGTAFT APRGQNRRSW LYRIRPAAVH GSFSLVEQSH FHNDFGAGPV PPDQLRWSPL 

       130        140        150        160        170        180 
PLPSVPTDFV DGLYTMAGNG GPEAMSGVGV HVYAANASMQ DRFFYDADGE LLLVPQQGRL 

       190        200        210        220        230        240 
RVHTELGVLA LEPQQIGVIP RGMRFRVELL DAAARGYVCE NFGGLLRLPD LGPIGANGLA 

       250        260        270        280        290        300 
NPRDFETPHA AFEQREGTFE LVAKFQGHLW RADIGHSPLD VVAWHGNYAP YRYDLRRFNT 

       310        320        330        340        350        360 
IGSISFDHPD PSIFTVLTSP SDTHGTANMD FAIFPPRWLV AQHTFRPPWF HRNVASEFMG 

       370        380        390        400        410        420 
LVHGVYDAKA EGFAPGGASL HNCMSGHGPD AATFDKASQA DLTRPDVIAD TMAFMFETRA 

       430        440        450 
VLRPTQQALS AAHRQADYQQ CWSGLRAAFQ PPITEDAT 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM35345.1.
RefSeqNP_640809.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PQ74.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC0454.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM35345; AAM35345; XAC0454.
GeneID1154525.
KEGGxac:XAC0454.
PATRIC24052775. VBIXanAxo33670_0489.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG3508.
HOGENOMHOG000139824.
KOK00451.
OMACWEPLKS.
OrthoDBEOG6D5FZK.
ProtClustDBPRK05341.

Enzyme and pathway databases

BioCycXAXO190486:GH55-454-MONOMER.
UniPathwayUPA00139; UER00339.

Family and domain databases

Gene3D2.60.120.10. 2 hits.
HAMAPMF_00334. Homogentis_dioxygen.
InterProIPR005708. Homogentis_dOase.
IPR022950. Homogentis_dOase_bac.
IPR014710. RmlC-like_jellyroll.
IPR011051. RmlC_Cupin.
[Graphical view]
PANTHERPTHR11056. PTHR11056. 1 hit.
PfamPF04209. HgmA. 1 hit.
[Graphical view]
SUPFAMSSF51182. SSF51182. 1 hit.
TIGRFAMsTIGR01015. hmgA. 1 hit.
ProtoNetSearch...

Entry information

Entry nameHGD_XANAC
AccessionPrimary (citable) accession number: Q8PQ74
Entry history
Integrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways