Reviewed, UniProtKB/Swiss-Prot Q8PQ74 (HGD_XANAC)

Names and origin

Protein names

Recommended name:
    Homogentisate 1,2-dioxygenase
    EC=1.13.11.5
Alternative name(s):
    Homogentisicase
    Homogentisate oxygenase
    Homogentisic acid oxidase

Gene names

Name:	hmgA
Ordered Locus Names:	XAC0454

Organism

Xanthomonas axonopodis pv. citri (Citrus canker) [Complete proteome] [HAMAP]

Taxonomic identifier

92829 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	458 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	Homogentisate + O2 = 4-maleylacetoacetate. HAMAP MF_00334
Cofactor	Iron By similarity.
Pathway	Amino-acid degradation; L-phenylalanine degradation; acetoacetate and fumarate from L-phenylalanine: step 4/6. HAMAP MF_00334
Sequence similarities	Belongs to the homogentisate dioxygenase family.

Ontologies

Keywords
Biological process	Phenylalanine catabolism Tyrosine catabolism
Ligand	Iron Metal-binding
Molecular function	Dioxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	L-phenylalanine catabolic process Inferred from electronic annotation. Source: HAMAP oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW tyrosine catabolic process Inferred from electronic annotation. Source: HAMAP
Molecular function	homogentisate 1,2-dioxygenase activity Inferred from electronic annotation. Source: HAMAP iron ion binding Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 458	458	Homogentisate 1,2-dioxygenase HAMAP MF_00334		PRO_0000220257
Sites
	Metal binding	351	1	Iron By similarity
	Metal binding	357	1	Iron By similarity
	Metal binding	387	1	Iron By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8PQ74-1 [UniParc]. Last modified October 10, 2002. Version 1. Checksum: E2237A2256088FDD	FASTA	458	50,450
	10 20 30 40 50 60 MIQRDPNLLL SWRADQHPDA PMHNDQRYMT GFGNEFATEA VAGSLPIGQN SPQRVAHGLY 70 80 90 100 110 120 AEQLSGTAFT APRGQNRRSW LYRIRPAAVH GSFSLVEQSH FHNDFGAGPV PPDQLRWSPL 130 140 150 160 170 180 PLPSVPTDFV DGLYTMAGNG GPEAMSGVGV HVYAANASMQ DRFFYDADGE LLLVPQQGRL 190 200 210 220 230 240 RVHTELGVLA LEPQQIGVIP RGMRFRVELL DAAARGYVCE NFGGLLRLPD LGPIGANGLA 250 260 270 280 290 300 NPRDFETPHA AFEQREGTFE LVAKFQGHLW RADIGHSPLD VVAWHGNYAP YRYDLRRFNT 310 320 330 340 350 360 IGSISFDHPD PSIFTVLTSP SDTHGTANMD FAIFPPRWLV AQHTFRPPWF HRNVASEFMG 370 380 390 400 410 420 LVHGVYDAKA EGFAPGGASL HNCMSGHGPD AATFDKASQA DLTRPDVIAD TMAFMFETRA 430 440 450 VLRPTQQALS AAHRQADYQQ CWSGLRAAFQ PPITEDAT

References

[1]

"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities." da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P. , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P. Nature 417:459-463(2002) [PubMed: 12024217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 306.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008923 Genomic DNA. Translation: AAM35345.1.
RefSeq	NP_640809.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1154525.
GenomeReviews	Gene locus XAC0454 in contig AE008923_GR.
KEGG	xac:XAC0454.
NMPDR	fig|190486.1.peg.453.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8PQ74.
OMA	RNCMSEF
Enzyme and pathway databases
BioCyc	XAXO190486:XAC0454-MON.
BRENDA	1.13.11.5. 289771.
Family and domain databases
HAMAP	MF_00334. [Tree]
InterPro	IPR011051. Cupin_RmlC_type. IPR005708. Homogentis_dOase. [Graphical view]
PANTHER	PTHR11056. Homogentis_dOase. 1 hit.
Pfam	PF04209. HgmA. 1 hit. [Graphical view]
TIGRFAMs	TIGR01015. hmgA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HGD_XANAC

Accession

Primary (citable) accession number: Q8PQ74

Entry history

Integrated into UniProtKB/Swiss-Prot:	October 10, 2002
Last sequence update:	October 10, 2002
Last modified:	November 24, 2009
This is version 45 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)