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Protein

CRP-like protein Clp

Gene

clp

Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Global transcriptional regulator that regulates virulence factors production by activating or repressing the expression of a large set of genes in diffusible signal factor (DSF) pathway.By similarity

Enzyme regulationi

Allosterically inhibited by cyclic di-GMP (c-di-GMP), which binds to Clp and abolishes its ability to bind its target gene promoter.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 139cNMPAdd BLAST122
DNA bindingi190 – 209H-T-H motifPROSITE-ProRule annotationAdd BLAST20

GO - Molecular functioni

  • catalytic activity Source: UniProtKB-KW
  • cyclic-di-GMP binding Source: UniProtKB
  • DNA binding Source: UniProtKB
  • DNA binding transcription factor activity Source: UniProtKB
  • protein dimerization activity Source: UniProtKB

GO - Biological processi

Keywordsi

Molecular functionActivator, Allosteric enzyme, DNA-binding, Repressor
Biological processTranscription, Transcription regulation, Virulence
Ligandc-di-GMP

Names & Taxonomyi

Protein namesi
Recommended name:
CRP-like protein Clp
Alternative name(s):
Catabolite activation-like protein
Short name:
CAP-like
Gene namesi
Name:clp
Ordered Locus Names:XAC0483
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000000576 Componenti: Chromosome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004057011 – 230CRP-like protein ClpAdd BLAST230

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi190486.XAC0483

Structurei

3D structure databases

ProteinModelPortaliQ8PQ45
SMRiQ8PQ45
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini158 – 230HTH crp-typePROSITE-ProRule annotationAdd BLAST73

Domaini

Binding of c-di-GMP appears to trigger the active Clp conformation into an open form or inactive state, hence abolishing its DNA-binding ability.By similarity

Phylogenomic databases

eggNOGiENOG4107RYR Bacteria
COG0664 LUCA
HOGENOMiHOG000250565
KOiK10914
OMAiTECEVAE
OrthoDBiPOG091H00WB

Family and domain databases

CDDicd00038 CAP_ED, 1 hit
Gene3Di1.10.10.10, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR018490 cNMP-bd-like
IPR000595 cNMP-bd_dom
IPR012318 HTH_CRP
IPR014710 RmlC-like_jellyroll
IPR018335 Tscrpt_reg_HTH_Crp-type_CS
IPR036388 WH-like_DNA-bd_sf
IPR036390 WH_DNA-bd_sf
PfamiView protein in Pfam
PF00027 cNMP_binding, 1 hit
PF00325 Crp, 1 hit
PRINTSiPR00034 HTHCRP
SMARTiView protein in SMART
SM00100 cNMP, 1 hit
SM00419 HTH_CRP, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit
SSF51206 SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS50042 CNMP_BINDING_3, 1 hit
PS00042 HTH_CRP_1, 1 hit
PS51063 HTH_CRP_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PQ45-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSPGNTTVVT TTVRNATPSL ALDAGTIERF LAHSHRRRYP TRTDVFRPGD
60 70 80 90 100
PAGTLYYVIS GSVSIIAEED DDRELVLGYF GSGEFVGEMG LFIESDTREV
110 120 130 140 150
ILRTRTQCEL AEISYERLQQ LFQTSLSPDA PKILYAIGVQ LSKRLLDTTR
160 170 180 190 200
KASRLAFLDV TDRIVRTLHD LAKEPEAMSH PQGTQLRVSR QELARLVGCS
210 220 230
REMAGRVLKK LQADGLLHAR GKTVVLYGTR
Length:230
Mass (Da):25,621
Last modified:October 1, 2002 - v1
Checksum:i6175A9AB2D4C1B30
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA Translation: AAM35374.1
RefSeqiWP_005914205.1, NC_003919.1

Genome annotation databases

EnsemblBacteriaiAAM35374; AAM35374; XAC0483
GeneIDi34207228
KEGGixac:XAC0483

Similar proteinsi

Entry informationi

Entry nameiCLP_XANAC
AccessioniPrimary (citable) accession number: Q8PQ45
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 8, 2011
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 96 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health