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Q8PQ21 (PUR2_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Phosphoribosylamine--glycine ligase

EC=6.3.4.13
Alternative name(s):
GARS
Glycinamide ribonucleotide synthetase
Phosphoribosylglycinamide synthetase
Gene names
Name:purD
Ordered Locus Names:XAC0511
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length431 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N(1)-(5-phospho-D-ribosyl)glycinamide. HAMAP-Rule MF_00138

Cofactor

Binds 1 magnesium or manganese ion per subunit By similarity.

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-alpha-D-ribose 1-diphosphate: step 2/2. HAMAP-Rule MF_00138

Sequence similarities

Belongs to the GARS family.

Contains 1 ATP-grasp domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 431431Phosphoribosylamine--glycine ligase HAMAP-Rule MF_00138
PRO_0000151502

Regions

Domain109 – 316208ATP-grasp
Nucleotide binding135 – 19662ATP By similarity

Sites

Metal binding2861Magnesium or manganese By similarity
Metal binding2881Magnesium or manganese By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PQ21 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 2E765A07B1F90F75

FASTA43144,890
        10         20         30         40         50         60 
MKILVIGSGG REHALAWKIA QSARVSEVLV APGNAGTATE AKCRNVAIKV DDLDGLLALA 

        70         80         90        100        110        120 
QREAVALTVV GPEVPLVLGV VDRFHAAGLR IFGPTAKAAQ LEGSKAFAKD FLARHGIPTA 

       130        140        150        160        170        180 
YYAVHTEVDA ALAYVREKGT PIVVKADGLA AGKGVIVALT LAEAEDAVRD MLSGNAFGDA 

       190        200        210        220        230        240 
GARVVIEEFL DGEEASFISM VDGKHALPMA TSQDHKRVGD GDTGPNTGGM GAYSPAPVVT 

       250        260        270        280        290        300 
PEVHARVMRE VVEPTVQGMI ADGVPFTGFL YAGLMIDAHG APKVIEFNVR FGDPETQPVM 

       310        320        330        340        350        360 
LRLQSDLVDL LEAAIDGKLD GAHAQWDPRP SLGVVIAARP YPDTPVTGEV IAGLDAVPAS 

       370        380        390        400        410        420 
AKVFHAGTAL NAAGEVVSAG GRVLCVAALG DSVQDAQRTA YAGLKPIHWS SAFQRSDIGW 

       430 
RAIARERQAQ G 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM35400.1.
RefSeqNP_640864.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PQ21.
SMRQ8PQ21. Positions 1-425.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC0511.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM35400; AAM35400; XAC0511.
GeneID1154582.
KEGGxac:XAC0511.
PATRIC24052907. VBIXanAxo33670_0553.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0151.
HOGENOMHOG000033463.
KOK01945.
OMADPEAMNV.
OrthoDBEOG69SKD1.
ProtClustDBPRK00885.

Enzyme and pathway databases

BioCycXAXO190486:GH55-511-MONOMER.
UniPathwayUPA00074; UER00125.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 1 hit.
3.40.50.20. 1 hit.
3.90.600.10. 1 hit.
HAMAPMF_00138. GARS.
InterProIPR011761. ATP-grasp.
IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR020561. PRibGlycinamid_synth_ATP-grasp.
IPR000115. PRibGlycinamide_synth.
IPR020560. PRibGlycinamide_synth_C-dom.
IPR020559. PRibGlycinamide_synth_CS.
IPR020562. PRibGlycinamide_synth_N.
IPR011054. Rudment_hybrid_motif.
[Graphical view]
PfamPF01071. GARS_A. 1 hit.
PF02843. GARS_C. 1 hit.
PF02844. GARS_N. 1 hit.
[Graphical view]
SUPFAMSSF51246. SSF51246. 1 hit.
SSF52440. SSF52440. 1 hit.
TIGRFAMsTIGR00877. purD. 1 hit.
PROSITEPS50975. ATP_GRASP. 1 hit.
PS00184. GARS. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry namePUR2_XANAC
AccessionPrimary (citable) accession number: Q8PQ21
Entry history
Integrated into UniProtKB/Swiss-Prot: November 15, 2002
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways