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Q8PQ19 (PUR9_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 75. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Bifunctional purine biosynthesis protein PurH

Including the following 2 domains:

  1. Phosphoribosylaminoimidazolecarboxamide formyltransferase
    EC=2.1.2.3
    Alternative name(s):
    AICAR transformylase
  2. IMP cyclohydrolase
    EC=3.5.4.10
    Alternative name(s):
    ATIC
    IMP synthase
    Inosinicase
Gene names
Name:purH
Ordered Locus Names:XAC0513
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length527 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

10-formyltetrahydrofolate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide = tetrahydrofolate + 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

IMP + H2O = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide. HAMAP-Rule MF_00139

Pathway

Purine metabolism; IMP biosynthesis via de novo pathway; 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide (10-formyl THF route): step 1/1. HAMAP-Rule MF_00139

Purine metabolism; IMP biosynthesis via de novo pathway; IMP from 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide: step 1/1.

Domain

The IMP cyclohydrolase activity resides in the N-terminal region By similarity. HAMAP-Rule MF_00139

Sequence similarities

Belongs to the PurH family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 527527Bifunctional purine biosynthesis protein PurH HAMAP-Rule MF_00139
PRO_0000192149

Sequences

Sequence LengthMass (Da)Tools
Q8PQ19 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 738956159DDD1A95

FASTA52755,726
        10         20         30         40         50         60 
MASDFLPVRR ALLSVSDKTG LIDLARALVA RNVELLSTGG TAKAIREAGL PVKDVAELTG 

        70         80         90        100        110        120 
FPEMMDGRVK TLHPLVHGGL LGRAGVDEAV MAEHGIVPID LLVLNLYPFE SVTVKADCTL 

       130        140        150        160        170        180 
ADAVENIDIG GPAMLRSAAK NFARVAVAAD PAQYADLLVE LEANDGQLSA AKRFALSVAA 

       190        200        210        220        230        240 
FNRVAQYDAA ISNYLSAVAD SAEAVPTRSP FPAQINSNFV KVMDLRYGEN PHQSGAFYRD 

       250        260        270        280        290        300 
LYPVPGTLAT FQQLQGKELS YNNLADADAA WECVRQFDAP ACVIVKHANP CGVAVGAGCG 

       310        320        330        340        350        360 
DAYELAYATD PTSAFGGILA FNKTLDAATA KAILDRQFVE VLIAPDYEAG ALEYATKKAN 

       370        380        390        400        410        420 
VRVLKIPHGN GLNNYDTKRI GSGLLMQSAD NRGMSQGELS VVTQRAPNEA ELGDLLFAWR 

       430        440        450        460        470        480 
VAKYVKSNAI VYAKDNRTIG VGAGQMSRVV SAKIAALKAE EAKLTVAGSV MASDAFFPFR 

       490        500        510        520 
DGIDAAAAAG IKAVIQPGGS MRDGEVIAAA DEHGIAMVFT GVRHFRH 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM35402.1.
RefSeqNP_640866.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PQ19.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC0513.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM35402; AAM35402; XAC0513.
GeneID1154584.
KEGGxac:XAC0513.
PATRIC24052911. VBIXanAxo33670_0555.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0138.
HOGENOMHOG000230373.
KOK00602.
OMADLLFAWK.
OrthoDBEOG6QCDFF.
ProtClustDBPRK00881.

Enzyme and pathway databases

BioCycXAXO190486:GH55-513-MONOMER.
UniPathwayUPA00074; UER00133.
UPA00074; UER00135.

Family and domain databases

Gene3D3.40.140.20. 2 hits.
3.40.50.1380. 1 hit.
HAMAPMF_00139. PurH.
InterProIPR024051. AICAR_Tfase_dom.
IPR002695. AICARFT_IMPCHas.
IPR016193. Cytidine_deaminase-like.
IPR011607. MGS-like_dom.
[Graphical view]
PANTHERPTHR11692. PTHR11692. 1 hit.
PfamPF01808. AICARFT_IMPCHas. 1 hit.
PF02142. MGS. 1 hit.
[Graphical view]
PIRSFPIRSF000414. AICARFT_IMPCHas. 1 hit.
SMARTSM00798. AICARFT_IMPCHas. 1 hit.
SM00851. MGS. 1 hit.
[Graphical view]
SUPFAMSSF52335. SSF52335. 1 hit.
SSF53927. SSF53927. 1 hit.
TIGRFAMsTIGR00355. purH. 1 hit.
ProtoNetSearch...

Entry information

Entry namePUR9_XANAC
AccessionPrimary (citable) accession number: Q8PQ19
Entry history
Integrated into UniProtKB/Swiss-Prot: June 20, 2003
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways