Q8PPG8 (BETA_XANAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Choline dehydrogenase
Short name=CDH
Short name=CHD
EC=1.1.99.1

Gene names

Name:	betA
Ordered Locus Names:	XAC0718

Organism

Xanthomonas axonopodis pv. citri (Citrus canker) [Complete proteome] [HAMAP]

Taxonomic identifier

92829 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	556 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Function	Can catalyze the oxidation of choline to betaine aldehyde and betaine aldehyde to glycine betaine By similarity. HAMAP MF_00750
Catalytic activity	Choline + acceptor = betaine aldehyde + reduced acceptor. HAMAP MF_00750
Cofactor	FAD By similarity. HAMAP MF_00750
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine aldehyde from choline (cytochrome c reductase route): step 1/1. HAMAP MF_00750
Sequence similarities	Belongs to the GMC oxidoreductase family.

Ontologies

Keywords
Ligand	FAD Flavoprotein
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	glycine betaine biosynthetic process from choline Inferred from electronic annotation. Source: InterPro
Molecular function	choline dehydrogenase activity Inferred from electronic annotation. Source: EC flavin adenine dinucleotide binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 556	556	Choline dehydrogenase HAMAP MF_00750		PRO_0000205608
Regions
	Nucleotide binding	6 – 35	30	FAD Potential
Sites
	Active site	475	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8PPG8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 026BB7F3EEE9B8DA	FASTA	556	61,266
	10 20 30 40 50 60 MQREYDYIII GAGSAGNVLA ARLTEDPGVT VLLLEAGGPD YRVDFRTQMP AALAFPLQGR 70 80 90 100 110 120 RYNWAYETEP EPYMDNRRME CGRGKGLGGS SLINGMCYIR GNALDFDHWA KRPGLEDWSY 130 140 150 160 170 180 RDVLPYFRKA ETRDIGANDY HGGDGPVSVA TPKNDNNVLF HAMVEAGVQA GYPRTGDLNG 190 200 210 220 230 240 YQQEGFGPMD RTVTPRGRRA STARGYLDMA KPRDGLHIVT HATTDRILFA GKRAIGVHYL 250 260 270 280 290 300 VGNSSEGIDA HARREVLVCA GAIASPQLLQ RSGVGAPDLL RALDVQLVHD LPGVGQNLQD 310 320 330 340 350 360 HLEVYIQYAC TKPVSLYPAL QWWNQPAIGA QWLFAGTGTG ASNQFEAGGF IRTREEFDWP 370 380 390 400 410 420 NIQYHFLPVA INYNGSNAVK EHGFQAHVGS MRTPSRGRVH AKSRDPRQHP SILFNYQSTD 430 440 450 460 470 480 QDWQEFRDAI RITREIIAQP ALDAYRGREI SPSADCKTDA ELDAFVRSRA ETAYHPSCSC 490 500 510 520 530 540 AMGTDAMAVV DGQGRVHGME GLRVIDASIM PRIITGNLNA TTIMIAEKIA DRVRGRTPLP 550 RSTADYYIAG DAPVRG

References

[1]

"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities." da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P. , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P. Nature 417:459-463(2002) [PubMed: 12024217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 306.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008923 Genomic DNA. Translation: AAM35607.1.
RefSeq	NP_641071.1. NC_003919.1.
3D structure databases
ProteinModelPortal	Q8PPG8.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1154789.
GenomeReviews	Gene locus XAC0718 in contig AE008923_GR.
KEGG	xac:XAC0718.
NMPDR	fig|190486.1.peg.715.
PATRIC	24053350. VBIXanAxo33670_0774.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG734713.
OMA	EISPGAH.
ProtClustDB	PRK02106.
Enzyme and pathway databases
BioCyc	XAXO190486:XAC0718-MONOMER.
Family and domain databases
HAMAP	MF_00750. Choline_dehydrogen. [Tree]
InterPro	IPR011533. Choline_dehydrogenase. IPR012132. GMC_OxRdtase. IPR000172. GMC_OxRdtase_N. IPR007867. GMC_OxRtase_C. [Graphical view]
KO	K00108.
Pfam	PF05199. GMC_oxred_C. 1 hit. PF00732. GMC_oxred_N. 1 hit. [Graphical view]
PIRSF	PIRSF000137. Alcohol_oxidase. 1 hit.
TIGRFAMs	TIGR01810. BetA. 1 hit.
PROSITE	PS00623. GMC_OXRED_1. 1 hit. PS00624. GMC_OXRED_2. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETA_XANAC

Accession

Primary (citable) accession number: Q8PPG8

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 16, 2004
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program