Q8PPG7 (BETB_XANAC) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Betaine aldehyde dehydrogenase
Short name=BADH
EC=1.2.1.8

Gene names

Name:	betB
Ordered Locus Names:	XAC0719

Organism

Xanthomonas axonopodis pv. citri (Citrus canker) [Complete proteome] [HAMAP]

Taxonomic identifier

92829 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	490 AA.
Sequence status	Complete.
Protein existence	Inferred from homology

General annotation (Comments)

Catalytic activity	Betaine aldehyde + NAD+ + H2O = betaine + NADH. HAMAP MF_00804
Pathway	Amine and polyamine biosynthesis; betaine biosynthesis via choline pathway; betaine from betaine aldehyde: step 1/1. HAMAP MF_00804
Sequence similarities	Belongs to the aldehyde dehydrogenase family.

Ontologies

Keywords
Ligand	NAD
Molecular function	Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	betaine biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	betaine-aldehyde dehydrogenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 490	490	Betaine aldehyde dehydrogenase HAMAP MF_00804		PRO_0000056558
Regions
	Nucleotide binding	229 – 234	6	NAD By similarity
Sites
	Active site	252	1	By similarity
	Active site	286	1	By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8PPG7 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 856F2EF716305179	FASTA	490	52,381
	10 20 30 40 50 60 MPRFPDQLLY IGGRYVPARG GHTLEVVNPA TGEVLANVHN AGVDDLDAAV DSAKAGQQRW 70 80 90 100 110 120 AALTTVERSR ILLRAVALLR ERNDALAQLE TLNTGKPLSE TRSVDVVTGA DVLEYYAGVA 130 140 150 160 170 180 QALQGAQVPL REGSFFYTRH EPLGVVGAIG AWNYPIQIAL WKAAPALAAG NAMIFKPSEV 190 200 210 220 230 240 TPLTALKLAE IFTEAGLPDG VFNVLPGDGA SVGTALTEHP QIEKISFTGG TATGRKVMAS 250 260 270 280 290 300 ASSSSLKEVT MELGGKSPLI VCADADLDVA ADIAMMANFY SSGQVCTNGT RVFVPRALRH 310 320 330 340 350 360 AFEARLLARV QRIHIGDPLD ERTTFGPLAS AAHMQRVLEH IEQGKAEGAR LLCGGERLQD 370 380 390 400 410 420 GALVQGYYVA PTIFSDCTDV MTIVREEIFG PVLSLLTYDD EDEAVTRANA TTYGLAAGVV 430 440 450 460 470 480 TPDLARAHRL IHRLEAGICW VNTWGESPAP MPVGGYKQSG VGRENGLATL QAYTRTKSVQ 490 IELERYASVF

References

[1]

"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities." da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P. , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P. Nature 417:459-463(2002) [PubMed: 12024217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 306.

+

Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008923 Genomic DNA. Translation: AAM35608.1.
RefSeq	NP_641072.1. NC_003919.1.
3D structure databases
ProteinModelPortal	Q8PPG7.
ModBase	Search...
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
GeneID	1154790.
GenomeReviews	Gene locus XAC0719 in contig AE008923_GR.
KEGG	xac:XAC0719.
NMPDR	fig|190486.1.peg.716.
PATRIC	24053352. VBIXanAxo33670_0775.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG752218.
OMA	GRENGLM.
ProtClustDB	PRK13252.
Enzyme and pathway databases
BioCyc	XAXO190486:XAC0719-MONOMER.
Family and domain databases
HAMAP	MF_00804. BADH. [Tree]
InterPro	IPR016161. Ald_DH/histidinol_DH. IPR016163. Ald_DH_C. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH_dom. IPR011264. Betaine_Ald_DH. [Graphical view]
Gene3D	G3DSA:3.40.309.10. Aldehyde_dehydrogenase_C. 1 hit. G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit.
KO	K00130.
Pfam	PF00171. Aldedh. 1 hit. [Graphical view]
SUPFAM	SSF53720. Aldehyde_DH/Histidinol_DH. 1 hit.
TIGRFAMs	TIGR01804. BADH. 1 hit.
PROSITE	PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

BETB_XANAC

Accession

Primary (citable) accession number: Q8PPG7

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 1, 2005
Last sequence update:	October 1, 2002
Last modified:	January 25, 2012
This is version 62 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Prokaryotic Protein Annotation Program