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Protein

Adenosylhomocysteinase

Gene

ahcY

Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.UniRule annotation

Catalytic activityi

S-adenosyl-L-homocysteine + H2O = L-homocysteine + adenosine.UniRule annotation

Cofactori

NAD+UniRule annotationNote: Binds 1 NAD+ per subunit.UniRule annotation

Pathwayi: L-homocysteine biosynthesis

This protein is involved in step 1 of the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine.UniRule annotation
Proteins known to be involved in this subpathway in this organism are:
  1. Adenosylhomocysteinase (ahcY)
This subpathway is part of the pathway L-homocysteine biosynthesis, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-homocysteine from S-adenosyl-L-homocysteine, the pathway L-homocysteine biosynthesis and in Amino-acid biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei63SubstrateUniRule annotation1
Binding sitei142SubstrateUniRule annotation1
Binding sitei203SubstrateUniRule annotation1
Binding sitei233SubstrateUniRule annotation1
Binding sitei237SubstrateUniRule annotation1
Binding sitei238NADUniRule annotation1
Binding sitei290NADUniRule annotation1
Binding sitei325NADUniRule annotation1
Binding sitei394NADUniRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi204 – 206NADUniRule annotation3
Nucleotide bindingi267 – 272NADUniRule annotation6
Nucleotide bindingi346 – 348NADUniRule annotation3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHydrolase
Biological processOne-carbon metabolism
LigandNAD

Enzyme and pathway databases

UniPathwayiUPA00314; UER00076.

Names & Taxonomyi

Protein namesi
Recommended name:
AdenosylhomocysteinaseUniRule annotation (EC:3.3.1.1UniRule annotation)
Alternative name(s):
S-adenosyl-L-homocysteine hydrolaseUniRule annotation
Short name:
AdoHcyaseUniRule annotation
Gene namesi
Name:ahcYUniRule annotation
Synonyms:sahH
Ordered Locus Names:XAC0804
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000000576 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001169961 – 480AdenosylhomocysteinaseAdd BLAST480

Interactioni

Protein-protein interaction databases

STRINGi190486.XAC0804.

Structurei

3D structure databases

ProteinModelPortaliQ8PP84.
SMRiQ8PP84.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the adenosylhomocysteinase family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C3E. Bacteria.
COG0499. LUCA.
HOGENOMiHOG000227986.
KOiK01251.
OMAiTGNRDII.
OrthoDBiPOG091H00W2.

Family and domain databases

CDDicd00401. SAHH. 1 hit.
HAMAPiMF_00563. AdoHcyase. 1 hit.
InterProiView protein in InterPro
IPR034373. Adenosylhomocysteinase.
IPR000043. Adenosylhomocysteinase-like.
IPR015878. Ado_hCys_hydrolase_NAD-bd.
IPR036291. NAD(P)-bd_dom_sf.
IPR020082. S-Ado-L-homoCys_hydrolase_CS.
PANTHERiPTHR23420. PTHR23420. 1 hit.
PfamiView protein in Pfam
PF05221. AdoHcyase. 1 hit.
PF00670. AdoHcyase_NAD. 1 hit.
PIRSFiPIRSF001109. Ad_hcy_hydrolase. 1 hit.
SMARTiView protein in SMART
SM00996. AdoHcyase. 1 hit.
SM00997. AdoHcyase_NAD. 1 hit.
SUPFAMiSSF51735. SSF51735. 1 hit.
TIGRFAMsiTIGR00936. ahcY. 1 hit.
PROSITEiView protein in PROSITE
PS00738. ADOHCYASE_1. 1 hit.
PS00739. ADOHCYASE_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PP84-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNAVTKITPH TDYKIADISL ADWGRKELDI AEHEMPGLMS IRRKHAQTKP
60 70 80 90 100
LKDVRITGSL HMTIQTAVLI ETLKDIGADV RWASCNIFST QDHAAAAIAA
110 120 130 140 150
TGTPVFAWKG ETLEEYWDCT LDALTFTLPD GTLTGPELVV DDGGDVTLLI
160 170 180 190 200
HKGYELENGS TWVDEPASSH EEGVIKALLK RVAVERPGYW GRVVKDWKGV
210 220 230 240 250
SEETTTGVHR LYQIAEAGKL LIPAINVNDS VTKSKFDNLY GCRESLADGL
260 270 280 290 300
KRAMDVMLAG KVAVVCGYGD VGKGSAASLR AYGARVIVTE IDPICALQAS
310 320 330 340 350
MEGFEVNTIE STLGRADIYV TTTGNKDIIT VEHLQAMKDQ AIVCNIGHFD
360 370 380 390 400
NEIQVDALKA LKDVQKINIK PQVDKYVFPN GNAIFLLADG RLVNLGCATG
410 420 430 440 450
HPSFVMSNSF ANQTLAQIDL WEKRDTYEKK VYILPKHLDE EVARLHLEKI
460 470 480
GVKLTTLTKD QADYLGVDVA GPYKPDHYRY
Length:480
Mass (Da):52,799
Last modified:October 1, 2002 - v1
Checksum:i5EBBC690BA6C36E8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA. Translation: AAM35692.1.
RefSeqiWP_005921033.1. NC_003919.1.

Genome annotation databases

EnsemblBacteriaiAAM35692; AAM35692; XAC0804.
KEGGixac:XAC0804.

Similar proteinsi

Entry informationi

Entry nameiSAHH_XANAC
AccessioniPrimary (citable) accession number: Q8PP84
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 25, 2003
Last sequence update: October 1, 2002
Last modified: October 25, 2017
This is version 99 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families