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Protein

4-hydroxythreonine-4-phosphate dehydrogenase

Gene

pdxA

Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the NAD(P)-dependent oxidation of 4-(phosphohydroxy)-L-threonine (HTP) into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which spontaneously decarboxylates to form 3-amino-2-oxopropyl phosphate (AHAP).UniRule annotation

Miscellaneous

The active site is located at the dimer interface.UniRule annotation

Catalytic activityi

4-phosphonooxy-L-threonine + NAD+ = 3-amino-2-oxopropyl phosphate + CO2 + NADH.

Cofactori

Zn2+UniRule annotation, Mg2+UniRule annotation, Co2+UniRule annotationNote: Binds 1 divalent metal cation per subunit. Can use ions such as Zn2+, Mg2+ or Co2+.UniRule annotation

Pathwayi: pyridoxine 5'-phosphate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate.UniRule annotation
Proteins known to be involved in the 5 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. no protein annotated in this organism
  3. Phosphoserine aminotransferase (serC)
  4. 4-hydroxythreonine-4-phosphate dehydrogenase (pdxA)
  5. Pyridoxine 5'-phosphate synthase (pdxJ)
This subpathway is part of the pathway pyridoxine 5'-phosphate biosynthesis, which is itself part of Cofactor biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes pyridoxine 5'-phosphate from D-erythrose 4-phosphate, the pathway pyridoxine 5'-phosphate biosynthesis and in Cofactor biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei133SubstrateUniRule annotation1
Metal bindingi161Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi206Divalent metal cation; shared with dimeric partnerUniRule annotation1
Metal bindingi261Divalent metal cation; shared with dimeric partnerUniRule annotation1
Binding sitei269SubstrateUniRule annotation1
Binding sitei278SubstrateUniRule annotation1
Binding sitei287SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processPyridoxine biosynthesis
LigandCobalt, Magnesium, Metal-binding, NAD, NADP, Zinc

Enzyme and pathway databases

UniPathwayiUPA00244; UER00312

Names & Taxonomyi

Protein namesi
Recommended name:
4-hydroxythreonine-4-phosphate dehydrogenaseUniRule annotation (EC:1.1.1.262UniRule annotation)
Alternative name(s):
4-(phosphohydroxy)-L-threonine dehydrogenaseUniRule annotation
Gene namesi
Name:pdxAUniRule annotation
Ordered Locus Names:XAC0864
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000000576 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001888371 – 3234-hydroxythreonine-4-phosphate dehydrogenaseAdd BLAST323

Interactioni

Subunit structurei

Homodimer.UniRule annotation

Protein-protein interaction databases

STRINGi190486.XAC0864

Structurei

3D structure databases

ProteinModelPortaliQ8PP24
SMRiQ8PP24
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the PdxA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CEZ Bacteria
COG1995 LUCA
HOGENOMiHOG000221592
KOiK00097
OMAiAPVHKGV
OrthoDBiPOG091H03XD

Family and domain databases

HAMAPiMF_00536 PdxA, 1 hit
InterProiView protein in InterPro
IPR037510 PdxA
IPR005255 PdxA_fam
PANTHERiPTHR30004 PTHR30004, 1 hit
PfamiView protein in Pfam
PF04166 PdxA, 1 hit
TIGRFAMsiTIGR00557 pdxA, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PP24-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMVPSLALVP GEPAGIGPEL CVRLAQQPRS DAHLIAYADP DTLHSAATAL
60 70 80 90 100
SLPVRLLEPD QPARAPGDLP LHPIRQAVAT RFGAPDPANA AAVIAGLRSA
110 120 130 140 150
AADCLAGRLQ GIVTGPVHKA AINAGGIAYT GTTELLAEQA GCPVVMMLAN
160 170 180 190 200
SIVRVALVTT HLPLRAVADA ITADALLQCL RITHAAMQRD FGLEHPRIAV
210 220 230 240 250
LGLNPHAGED GHLGREELDI VIPALEQLRG EGMQLIGPLP ADTAFLPQKL
260 270 280 290 300
RGFDAVVAMY HDQGLPVLKY SGFEQAVNIT LGLPYPRVAV DHGTALELAG
310 320
RGIADPSSLM AATALCARLA ARR
Length:323
Mass (Da):33,650
Last modified:October 10, 2002 - v1
Checksum:i13F6FCBB7201E418
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA Translation: AAM35752.1

Genome annotation databases

EnsemblBacteriaiAAM35752; AAM35752; XAC0864
KEGGixac:XAC0864

Similar proteinsi

Entry informationi

Entry nameiPDXA_XANAC
AccessioniPrimary (citable) accession number: Q8PP24
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2002
Last sequence update: October 10, 2002
Last modified: March 28, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health