Reviewed, UniProtKB/Swiss-Prot Q8PN74 (DNAE2_XANAC)

Names and origin

Protein names

Recommended name:
    Error-prone DNA polymerase
    EC=2.7.7.7

Gene names

Name:	dnaE2
Ordered Locus Names:	XAC1199

Organism

Xanthomonas axonopodis pv. citri (Citrus canker) [Complete proteome] [HAMAP]

Taxonomic identifier

92829 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	1083 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase By similarity.
Catalytic activity	Deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). HAMAP MF_01902
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the DNA polymerase type-C family. DnaE2 subfamily.

Ontologies

Keywords
Biological process	DNA damage DNA repair DNA replication
Cellular component	Cytoplasm
Molecular function	DNA-directed DNA polymerase Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	DNA replication Inferred from electronic annotation. Source: UniProtKB-KW error-prone DNA repair Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	3'-5' exonuclease activity Inferred from electronic annotation. Source: InterPro DNA binding Inferred from electronic annotation. Source: InterPro DNA-directed DNA polymerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1083	1083	Error-prone DNA polymerase HAMAP MF_01902		PRO_0000103404

Sequences

	Sequence		Length	Mass (Da)
	Q8PN74-1 [UniParc]. Last modified July 19, 2005. Version 2. Checksum: BFC1F06ADB9281A3	FASTA	1,083	120,563
	10 20 30 40 50 60 MSWDDAIDGV DRDTPGGRMP RAWNVAARLR AANDDIVHAQ QADGLPAYAE LHCLSDFSFL 70 80 90 100 110 120 RGASSAEQLF ARAQQCGYSA LAITDECSLA GIVRGLEASR ATGVRLIVGS EFTLVDGTRF 130 140 150 160 170 180 VLLVENAHGY PQLCGLITTA RRAASKGAYR LDRAEVQAQF RDVAPGVFAL WLPGAQPQAE 190 200 210 220 230 240 QGAWLQQVFG ERAFLAVELH REQDDVARLH VLQALAQQLG MTALASGDVH MAQRRERIVQ 250 260 270 280 290 300 DTLTAIRHTL PLAECGAHLF RNGERHLRTR RALGNIYPDA LLQATVELAQ RCTFDISKIS 310 320 330 340 350 360 YTYPRELVPE GHTPTSYLRQ LTEAGIRRRW PGGITAKVRE DIEKELALIA LKKYEAFFLT 370 380 390 400 410 420 VQDVVRFARE QNILCQGRGS SANSAVCYAL GITAVNPDET RLLMARFLSE KRDEPPDIDV 430 440 450 460 470 480 DFEHERREEV LQYVYSKYGR ERAALAATVI CYRGKSAVRD VAKAFGLPPD QIALLANCYG 490 500 510 520 530 540 WGNGETPMDQ RIEEAGFDLA NPLINKILAV TEHLRDHPRH LSQHVGGFVI SDEPLSLLVP 550 560 570 580 590 600 VENAAMANRT IIQWDKDDLE TMKLLKVDCL ALGMLTCIRK TLDLVRGHRG RNYSIATLPG 610 620 630 640 650 660 GDAPTYKMIQ RADTVGVFQI ESRAQMAMLP RLKPAAFYDL VIEVAIVRPG PIQGDMVHPY 670 680 690 700 710 720 LRRRQGREEV NYPSPAVEDI LKPTLGVPLF QEQVMELLMH AADYSEDEAD NLRRSMAAWR 730 740 750 760 770 780 RGGDMEQHRT RVRERMQGKG YASSFIDQIF EQIKGFGSYG FPQSHAASFA KLVYASCWLK 790 800 810 820 830 840 RHEPAAFACG LLNAQPMGFY SASQIVQDAR RGSPERERVE VLPVDVLHSD WDNTLVGGRP 850 860 870 880 890 900 WRSAADPGEQ PAIRLGMRQV AGLSQVVAQR IVAARTQRAF ADIGDLCLRA ALDEKARLAL 910 920 930 940 950 960 AEAGALQGMV GNRNAARWAM AGVEARCPLL PGSPEERPVE FEAPRAGEEI LADYRSVGLS 970 980 990 1000 1010 1020 LRQHPMALLR PQMRQRRILG LRELQGRRHG SGVHVAGLVT QRQRPATAKG TIFVTLEDEQ 1030 1040 1050 1060 1070 1080 GMINVIVWSH LALRRRRALL ESRLLAVRGR WERVDGVEHL IAGDLYDLSN LLGDMQLPSR DFH

References

[1]

"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities." da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P. , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P. Nature 417:459-463(2002) [PubMed: 12024217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 306.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE011749 Genomic DNA. Translation: AAM36071.1. Different initiation.
RefSeq	NP_641535.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1155270.
GenomeReviews	Gene locus XAC1199 in contig AE008923_GR.
KEGG	xac:XAC1199.
NMPDR	fig|190486.1.peg.1179.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8PN74.
Enzyme and pathway databases
BioCyc	XAXO190486:XAC1199-MON.
BRENDA	2.7.7.7. 289771.
Family and domain databases
HAMAP	MF_01902. [Tree]
InterPro	IPR011708. DNA_pol3_alpha. IPR004365. NA_bd_OB_tRNA-helicase. IPR004013. PHP_C. IPR003141. PHP_N. IPR004805. PolC_alpha. [Graphical view]
Pfam	PF07733. DNA_pol3_alpha. 1 hit. PF02811. PHP. 1 hit. PF01336. tRNA_anti. 1 hit. [Graphical view]
SMART	SM00481. POLIIIAc. 1 hit. [Graphical view]
TIGRFAMs	TIGR00594. polc. 1 hit.
ProtoNet	Search...

Entry information

Entry name

DNAE2_XANAC

Accession

Primary (citable) accession number: Q8PN74

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2005
Last sequence update:	July 19, 2005
Last modified:	June 16, 2009
This is version 42 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)