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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

Pyridoxal phosphate

Enzyme and pathway databases

BioCyciXAXO190486:GH55-1214-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:XAC1214
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
ProteomesiUP000000576 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 977977Glycine dehydrogenase (decarboxylating)PRO_0000166948Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei702 – 7021N6-(pyridoxal phosphate)lysineUniRule annotation

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi190486.XAC1214.

Structurei

3D structure databases

ProteinModelPortaliQ8PN59.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiANEFIAR.
OrthoDBiEOG6HMXDX.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8PN59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTPSSLRD LEHHSAFVER HIGPNDAEIA QMLDVVGHAS LDALTDAIVP
60 70 80 90 100
GNIKSPAPLA LPEAITEEEA LAKIRAIASK NQVQRNFIGQ GYYGTHTPKV
110 120 130 140 150
ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMQIANASL
160 170 180 190 200
LDEATAAAEA MTLAKRSAKS KSNTFFVHDA VHPQTLELLR TRAEPLDIVL
210 220 230 240 250
RVGTPEEALQ AECFGVLLQY PDSFGHIGDH AALADAVHAQ GGLVAVATDL
260 270 280 290 300
LALTLIAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG
310 320 330 340 350
RLIGVSIDAA GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA
360 370 380 390 400
VYHGPDGLVR IARRTHRLAA ILAAALRSAG VSVGDRFFDT LHVKAIDADA
410 420 430 440 450
IHARARAAGI NLRAIDSEAV GISLDETTTR ADVVALAQLF GATADVDALD
460 470 480 490 500
AATADALPQG LLRTTPFLTH PVFNTHHSEH ELLRYMRSLA DKDLAMDRTM
510 520 530 540 550
IPLGSCTMKL NATAEMIPVT WPEFGAIHPL APAEQSAGYA QLIDELEAML
560 570 580 590 600
VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGQAHRD ICLIPESAHG
610 620 630 640 650
TNPASAQMCG MTVVVTKCDA NGNVDVDDIR AKAEKYSDRL AALMITYPST
660 670 680 690 700
HGVFEEDVVA ICEAVHAHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL
710 720 730 740 750
HKTFCIPHGG GGPGVGPCAV KSHLAPYLPR AGIHAGEGQT AAIHGGGFNS
760 770 780 790 800
ESGNGHSSRI GGMVSAAAYG SASILPISWM YVTMMGSAGL RKATQVALLN
810 820 830 840 850
ANYIAKRLAP HYKTLYTGRN GLVAHECILD VRPLEKTSGI GAEDIAKRLI
860 870 880 890 900
DFGFHAPTLS FPVAGTLMVE PTESESQHEL DRFIDAMIQI REEIRAIEDG
910 920 930 940 950
RLDREDNPLK HAPHTATQVS ASEWTHAYPR ELAAFPLPSL KQQKYWPPVA
960 970
RVDNVYGDKN VMCACIPVDA YKEDAEA
Length:977
Mass (Da):104,699
Last modified:October 1, 2002 - v1
Checksum:i049E8B9B1357535E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA. Translation: AAM36086.1.
RefSeqiWP_011050782.1. NC_003919.1.

Genome annotation databases

EnsemblBacteriaiAAM36086; AAM36086; XAC1214.
KEGGixac:XAC1214.
PATRICi24054399. VBIXanAxo33670_1281.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA. Translation: AAM36086.1.
RefSeqiWP_011050782.1. NC_003919.1.

3D structure databases

ProteinModelPortaliQ8PN59.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi190486.XAC1214.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiAAM36086; AAM36086; XAC1214.
KEGGixac:XAC1214.
PATRICi24054399. VBIXanAxo33670_1281.

Phylogenomic databases

eggNOGiCOG1003.
HOGENOMiHOG000239369.
KOiK00281.
OMAiANEFIAR.
OrthoDBiEOG6HMXDX.

Enzyme and pathway databases

BioCyciXAXO190486:GH55-1214-MONOMER.

Family and domain databases

Gene3Di3.40.640.10. 2 hits.
HAMAPiMF_00711. GcvP.
InterProiIPR003437. GcvP.
IPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERiPTHR11773. PTHR11773. 1 hit.
PfamiPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMiSSF53383. SSF53383. 3 hits.
TIGRFAMsiTIGR00461. gcvP. 1 hit.
ProtoNetiSearch...

Publicationsi

  1. "Comparison of the genomes of two Xanthomonas pathogens with differing host specificities."
    da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P.
    , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P.
    Nature 417:459-463(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: 306.

Entry informationi

Entry nameiGCSP_XANAC
AccessioniPrimary (citable) accession number: Q8PN59
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2002
Last modified: July 22, 2015
This is version 83 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.