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Protein

Glycine dehydrogenase (decarboxylating)

Gene

gcvP

Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.UniRule annotation

Catalytic activityi

Glycine + [glycine-cleavage complex H protein]-N6-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N6-dihydrolipoyl-L-lysine + CO2.UniRule annotation

Cofactori

pyridoxal 5'-phosphateUniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandPyridoxal phosphate

Names & Taxonomyi

Protein namesi
Recommended name:
Glycine dehydrogenase (decarboxylating)UniRule annotation (EC:1.4.4.2UniRule annotation)
Alternative name(s):
Glycine cleavage system P-proteinUniRule annotation
Glycine decarboxylaseUniRule annotation
Glycine dehydrogenase (aminomethyl-transferring)UniRule annotation
Gene namesi
Name:gcvPUniRule annotation
Ordered Locus Names:XAC1214
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000000576 Componenti: Chromosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001669481 – 977Glycine dehydrogenase (decarboxylating)Add BLAST977

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei702N6-(pyridoxal phosphate)lysineUniRule annotation1

Interactioni

Subunit structurei

The glycine cleavage system is composed of four proteins: P, T, L and H.UniRule annotation

Protein-protein interaction databases

STRINGi190486.XAC1214

Structurei

3D structure databases

ProteinModelPortaliQ8PN59
SMRiQ8PN59
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the GcvP family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CBI Bacteria
COG0403 LUCA
COG1003 LUCA
HOGENOMiHOG000239369
KOiK00281
OMAiQTMVCDL
OrthoDBiPOG091H03O6

Family and domain databases

CDDicd00613 GDC-P, 2 hits
Gene3Di3.40.640.10, 2 hits
3.90.1150.10, 1 hit
HAMAPiMF_00711 GcvP, 1 hit
InterProiView protein in InterPro
IPR003437 GcvP
IPR020581 GDC_P
IPR015424 PyrdxlP-dep_Trfase
IPR015422 PyrdxlP-dep_Trfase_dom1
IPR015421 PyrdxlP-dep_Trfase_major
PANTHERiPTHR11773 PTHR11773, 1 hit
PfamiView protein in Pfam
PF02347 GDC-P, 2 hits
SUPFAMiSSF53383 SSF53383, 3 hits
TIGRFAMsiTIGR00461 gcvP, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PN59-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSQTPSSLRD LEHHSAFVER HIGPNDAEIA QMLDVVGHAS LDALTDAIVP
60 70 80 90 100
GNIKSPAPLA LPEAITEEEA LAKIRAIASK NQVQRNFIGQ GYYGTHTPKV
110 120 130 140 150
ILRNILENPA WYTAYTPYQA EISQGRMEAL INFQTLCADL TGMQIANASL
160 170 180 190 200
LDEATAAAEA MTLAKRSAKS KSNTFFVHDA VHPQTLELLR TRAEPLDIVL
210 220 230 240 250
RVGTPEEALQ AECFGVLLQY PDSFGHIGDH AALADAVHAQ GGLVAVATDL
260 270 280 290 300
LALTLIAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG
310 320 330 340 350
RLIGVSIDAA GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA
360 370 380 390 400
VYHGPDGLVR IARRTHRLAA ILAAALRSAG VSVGDRFFDT LHVKAIDADA
410 420 430 440 450
IHARARAAGI NLRAIDSEAV GISLDETTTR ADVVALAQLF GATADVDALD
460 470 480 490 500
AATADALPQG LLRTTPFLTH PVFNTHHSEH ELLRYMRSLA DKDLAMDRTM
510 520 530 540 550
IPLGSCTMKL NATAEMIPVT WPEFGAIHPL APAEQSAGYA QLIDELEAML
560 570 580 590 600
VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGQAHRD ICLIPESAHG
610 620 630 640 650
TNPASAQMCG MTVVVTKCDA NGNVDVDDIR AKAEKYSDRL AALMITYPST
660 670 680 690 700
HGVFEEDVVA ICEAVHAHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL
710 720 730 740 750
HKTFCIPHGG GGPGVGPCAV KSHLAPYLPR AGIHAGEGQT AAIHGGGFNS
760 770 780 790 800
ESGNGHSSRI GGMVSAAAYG SASILPISWM YVTMMGSAGL RKATQVALLN
810 820 830 840 850
ANYIAKRLAP HYKTLYTGRN GLVAHECILD VRPLEKTSGI GAEDIAKRLI
860 870 880 890 900
DFGFHAPTLS FPVAGTLMVE PTESESQHEL DRFIDAMIQI REEIRAIEDG
910 920 930 940 950
RLDREDNPLK HAPHTATQVS ASEWTHAYPR ELAAFPLPSL KQQKYWPPVA
960 970
RVDNVYGDKN VMCACIPVDA YKEDAEA
Length:977
Mass (Da):104,699
Last modified:October 1, 2002 - v1
Checksum:i049E8B9B1357535E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA Translation: AAM36086.1
RefSeqiWP_011050782.1, NC_003919.1

Genome annotation databases

EnsemblBacteriaiAAM36086; AAM36086; XAC1214
KEGGixac:XAC1214

Similar proteinsi

Entry informationi

Entry nameiGCSP_XANAC
AccessioniPrimary (citable) accession number: Q8PN59
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health