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Q8PN59 (GCSP_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 73. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Glycine dehydrogenase (decarboxylating)

EC=1.4.4.2
Alternative name(s):
Glycine cleavage system P-protein
Glycine decarboxylase
Glycine dehydrogenase (aminomethyl-transferring)
Gene names
Name:gcvP
Ordered Locus Names:XAC1214
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length977 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO2 is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein By similarity. HAMAP-Rule MF_00711

Catalytic activity

Glycine + [glycine-cleavage complex H protein]-N(6)-lipoyl-L-lysine = [glycine-cleavage complex H protein]-S-aminomethyl-N(6)-dihydrolipoyl-L-lysine + CO2. HAMAP-Rule MF_00711

Cofactor

Pyridoxal phosphate By similarity. HAMAP-Rule MF_00711

Subunit structure

The glycine cleavage system is composed of four proteins: P, T, L and H By similarity.

Sequence similarities

Belongs to the GcvP family.

Ontologies

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 977977Glycine dehydrogenase (decarboxylating) HAMAP-Rule MF_00711
PRO_0000166948

Amino acid modifications

Modified residue7021N6-(pyridoxal phosphate)lysine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PN59 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 049E8B9B1357535E

FASTA977104,699
        10         20         30         40         50         60 
MSQTPSSLRD LEHHSAFVER HIGPNDAEIA QMLDVVGHAS LDALTDAIVP GNIKSPAPLA 

        70         80         90        100        110        120 
LPEAITEEEA LAKIRAIASK NQVQRNFIGQ GYYGTHTPKV ILRNILENPA WYTAYTPYQA 

       130        140        150        160        170        180 
EISQGRMEAL INFQTLCADL TGMQIANASL LDEATAAAEA MTLAKRSAKS KSNTFFVHDA 

       190        200        210        220        230        240 
VHPQTLELLR TRAEPLDIVL RVGTPEEALQ AECFGVLLQY PDSFGHIGDH AALADAVHAQ 

       250        260        270        280        290        300 
GGLVAVATDL LALTLIAAPG EWGADIVVGN SQRFGVPFGF GGPHAAFMAC RDAYKRSMPG 

       310        320        330        340        350        360 
RLIGVSIDAA GNPAYRLTLQ TREQHIRREK ATSNICTAQV LLAVMASMYA VYHGPDGLVR 

       370        380        390        400        410        420 
IARRTHRLAA ILAAALRSAG VSVGDRFFDT LHVKAIDADA IHARARAAGI NLRAIDSEAV 

       430        440        450        460        470        480 
GISLDETTTR ADVVALAQLF GATADVDALD AATADALPQG LLRTTPFLTH PVFNTHHSEH 

       490        500        510        520        530        540 
ELLRYMRSLA DKDLAMDRTM IPLGSCTMKL NATAEMIPVT WPEFGAIHPL APAEQSAGYA 

       550        560        570        580        590        600 
QLIDELEAML VECTGYDAVS LQPNSGAQGE YAGLLAIRAY HRSRGQAHRD ICLIPESAHG 

       610        620        630        640        650        660 
TNPASAQMCG MTVVVTKCDA NGNVDVDDIR AKAEKYSDRL AALMITYPST HGVFEEDVVA 

       670        680        690        700        710        720 
ICEAVHAHGG QVYTDGANMN ALVGVAKPGK WGSDVSHLNL HKTFCIPHGG GGPGVGPCAV 

       730        740        750        760        770        780 
KSHLAPYLPR AGIHAGEGQT AAIHGGGFNS ESGNGHSSRI GGMVSAAAYG SASILPISWM 

       790        800        810        820        830        840 
YVTMMGSAGL RKATQVALLN ANYIAKRLAP HYKTLYTGRN GLVAHECILD VRPLEKTSGI 

       850        860        870        880        890        900 
GAEDIAKRLI DFGFHAPTLS FPVAGTLMVE PTESESQHEL DRFIDAMIQI REEIRAIEDG 

       910        920        930        940        950        960 
RLDREDNPLK HAPHTATQVS ASEWTHAYPR ELAAFPLPSL KQQKYWPPVA RVDNVYGDKN 

       970 
VMCACIPVDA YKEDAEA 

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Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM36086.1.
RefSeqNP_641550.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PN59.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC1214.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM36086; AAM36086; XAC1214.
GeneID1155285.
KEGGxac:XAC1214.
PATRIC24054399. VBIXanAxo33670_1281.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG1003.
HOGENOMHOG000239369.
KOK00281.
OMAIRVQVII.
OrthoDBEOG6HMXDX.
ProtClustDBPRK05367.

Enzyme and pathway databases

BioCycXAXO190486:GH55-1214-MONOMER.

Family and domain databases

Gene3D3.40.640.10. 2 hits.
HAMAPMF_00711. GcvP.
InterProIPR020580. GDC-P_N.
IPR020581. GDC_P.
IPR003437. GDC_P_homo.
IPR015424. PyrdxlP-dep_Trfase.
IPR015421. PyrdxlP-dep_Trfase_major_sub1.
[Graphical view]
PANTHERPTHR11773. PTHR11773. 1 hit.
PfamPF02347. GDC-P. 2 hits.
[Graphical view]
SUPFAMSSF53383. SSF53383. 3 hits.
TIGRFAMsTIGR00461. gcvP. 1 hit.
ProtoNetSearch...

Entry information

Entry nameGCSP_XANAC
AccessionPrimary (citable) accession number: Q8PN59
Entry history
Integrated into UniProtKB/Swiss-Prot: September 19, 2003
Last sequence update: October 1, 2002
Last modified: February 19, 2014
This is version 73 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families