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Q8PML8 (LPXB_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified May 14, 2014. Version 61. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lipid-A-disaccharide synthase

EC=2.4.1.182
Gene names
Name:lpxB
Ordered Locus Names:XAC1408
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length439 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell By similarity. HAMAP-Rule MF_00392

Catalytic activity

UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate. HAMAP-Rule MF_00392

Pathway

Glycolipid biosynthesis; lipid IV(A) biosynthesis; lipid IV(A) from (3R)-3-hydroxytetradecanoyl-[acyl-carrier-protein] and UDP-N-acetyl-alpha-D-glucosamine: step 5/6. HAMAP-Rule MF_00392

Sequence similarities

Belongs to the LpxB family.

Sequence caution

The sequence AAM36279.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processLipid A biosynthesis
Lipid biosynthesis
Lipid metabolism
   Molecular functionGlycosyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processlipid A biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionlipid-A-disaccharide synthase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 439439Lipid-A-disaccharide synthase HAMAP-Rule MF_00392
PRO_0000190193

Sequences

Sequence LengthMass (Da)Tools
Q8PML8 [UniParc].

Last modified October 31, 2006. Version 2.
Checksum: C25790ADA91615D9

FASTA43947,486
        10         20         30         40         50         60 
MKGIGNRESG IVDGQRNGAS VGSVTTALPI PDSPLPIPGA RKRAPRIALI AGEASGDILG 

        70         80         90        100        110        120 
AGLIEQLRLR YPNAEFVGIG GDAMRGVGCQ TWFDASELAV MGLTEVLRHL PRLLKLRSAF 

       130        140        150        160        170        180 
RERVLAWKPD VFIGIDAPDF NLPVERWLKQ RGIKTVHYVS PSVWAWREKR AEKIGVSADL 

       190        200        210        220        230        240 
VLCLFPMEPP IYAKHGVDAR FVGHPMADDI AYQSDRAAAR ATLGLSASST VLAVLPGSRH 

       250        260        270        280        290        300 
GEISRLGDTF FQAAWLVSEH LPNLHVLVPA ANPGCKQLLA EQLSRSSLPV MRSHLLDGQA 

       310        320        330        340        350        360 
RTAMLAADVV LLASGTATLE AMLVKRPMVV GYKVAPLTYR IVKLLGLLKV NRYALPNILA 

       370        380        390        400        410        420 
NDDLAPELMQ DDCTPERLCV ALLDWFKHPD KVAALQPRYL ALHAELRRDA SARAADAVAG 

       430 
LLSQRESGME NRESAGAGA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM36279.1. Different initiation.
RefSeqNP_641743.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PML8.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC1408.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM36279; AAM36279; XAC1408.
GeneID1155479.
KEGGxac:XAC1408.
PATRIC24054813. VBIXanAxo33670_1487.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0763.
HOGENOMHOG000018003.
KOK00748.
OMAVSPITYR.
OrthoDBEOG6FBWZR.

Enzyme and pathway databases

BioCycXAXO190486:GH55-1408-MONOMER.
UniPathwayUPA00359; UER00481.

Family and domain databases

HAMAPMF_00392. LpxB.
InterProIPR003835. Glyco_trans_19.
[Graphical view]
PfamPF02684. LpxB. 1 hit.
[Graphical view]
TIGRFAMsTIGR00215. lpxB. 1 hit.
ProtoNetSearch...

Entry information

Entry nameLPXB_XANAC
AccessionPrimary (citable) accession number: Q8PML8
Entry history
Integrated into UniProtKB/Swiss-Prot: May 9, 2003
Last sequence update: October 31, 2006
Last modified: May 14, 2014
This is version 61 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways