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Q8PMI8 (TPMT_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 53. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Thiopurine S-methyltransferase

EC=2.1.1.67
Alternative name(s):
Thiopurine methyltransferase
Gene names
Name:tpm
Ordered Locus Names:XAC1439
OrganismXanthomonas axonopodis pv. citri (Citrus canker) [Complete proteome] [HAMAP]
Taxonomic identifier92829 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length218 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether. HAMAP MF_00812

Subcellular location

Cytoplasm By similarity HAMAP MF_00812.

Sequence similarities

Belongs to the methyltransferase superfamily. TPMT family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandS-adenosyl-L-methionine
   Molecular functionMethyltransferase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Cellular componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functionthiopurine S-methyltransferase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 218218Thiopurine S-methyltransferase HAMAP MF_00812
PRO_0000220138

Sites

Binding site101S-adenosyl-L-methionine By similarity
Binding site451S-adenosyl-L-methionine; via carbonyl oxygen By similarity
Binding site661S-adenosyl-L-methionine By similarity
Binding site1231S-adenosyl-L-methionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PMI8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: E42AF9AC12211124

FASTA21824,607
        10         20         30         40         50         60 
MDTNFWLERW QLGHTGFHQQ EVLPLLQKHW HALDLPKESR VLVPLCGKTL DMHWLASQGH 

        70         80         90        100        110        120 
RVLGVELSPL AVTQFFDEAG LQPQRHTSAA GEHFIAGPIE IICGDAFALD ASVLADCTAV 

       130        140        150        160        170        180 
YDRAALVALP AELRQRYLQT VYVQLPTHCR GLLITLEYPQ AEKAGPPFSV DATHVHALFD 

       190        200        210 
AAWQVDQLER RDILDQEPRF RDEGVTGLST AVYRLQRR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM36310.1.
RefSeqNP_641774.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PMI8.
ModBaseSearch...

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

GeneID1155510.
GenomeReviewsGene locus XAC1439 in contig AE008923_GR.
KEGGxac:XAC1439.
NMPDRfig|190486.1.peg.1418.
PATRIC24054879. VBIXanAxo33670_1520.

Organism-specific databases

CMRSearch...

Phylogenomic databases

HOGENOMHBG444929.
OMAQGDIFTL.
ProtClustDBPRK13255.

Enzyme and pathway databases

BioCycXAXO190486:XAC1439-MONOMER.

Family and domain databases

HAMAPMF_00812. Thiopur_methtran.
[Tree]
InterProIPR022474. Thiopur_S-MeTfrase_Se/Te_detox.
IPR008854. Thiopurine_S-MeTrfase.
IPR016822. Thiopurine_S-MeTrfase_sub.
[Graphical view]
KOK00569.
PANTHERPTHR10259. PTHR10259. 1 hit.
PfamPF05724. TPMT. 1 hit.
[Graphical view]
PIRSFPIRSF023956. Thiopurine_S-methyltransferase. 1 hit.
TIGRFAMsTIGR03840. TMPT_Se_Te. 1 hit.
ProtoNetSearch...

Entry information

Entry nameTPMT_XANAC
AccessionPrimary (citable) accession number: Q8PMI8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: October 1, 2002
Last modified: January 25, 2012
This is version 53 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families