Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8PM39 (NADK_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
NAD kinase

EC=2.7.1.23
Alternative name(s):
ATP-dependent NAD kinase
Gene names
Name:nadK
Ordered Locus Names:XAC1595
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length258 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Function

Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP By similarity. HAMAP-Rule MF_00361

Catalytic activity

ATP + NAD+ = ADP + NADP+. HAMAP-Rule MF_00361

Cofactor

Divalent metal ions By similarity. HAMAP-Rule MF_00361

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00361.

Sequence similarities

Belongs to the NAD kinase family.

Ontologies

Keywords
   Cellular componentCytoplasm
   LigandATP-binding
NAD
NADP
Nucleotide-binding
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processNAD metabolic process

Inferred from electronic annotation. Source: InterPro

NADP biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

NAD+ kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 258258NAD kinase HAMAP-Rule MF_00361
PRO_0000120691

Regions

Nucleotide binding45 – 462NAD By similarity
Nucleotide binding117 – 1182NAD By similarity
Nucleotide binding158 – 1636NAD By similarity

Sites

Active site451Proton acceptor By similarity
Binding site1471NAD By similarity
Binding site1551NAD; via carbonyl oxygen By similarity
Binding site1821NAD; via carbonyl oxygen By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PM39 [UniParc].

Last modified October 25, 2002. Version 1.
Checksum: E9FC4709727F4595

FASTA25828,428
        10         20         30         40         50         60 
MTAPPRIAFL ASPAEPAVAA RARLTQRYGD HALDSADIVC ALGGDGFMLQ TLHRHGASDK 

        70         80         90        100        110        120 
PVFGMKLGSV GFLMNQYRDN EDDLLERLQR AEPAYLRPLE MQVQTESGAS AGSLAYNEVS 

       130        140        150        160        170        180 
LLRQTRQAAH LSIDLNGQTR IAELIGDGVM VATPAGSTAY NYSAHGPILP LGSHTLALTP 

       190        200        210        220        230        240 
IAPYRPRRWR GAILKADTEV RFRVLDPYKR PVSVTADSHE IRDVVEVTIR ESAQRQVTLL 

       250 
FDPEHNLEER IFSEQFAV 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM36463.1.
RefSeqNP_641927.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PM39.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC1595.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM36463; AAM36463; XAC1595.
GeneID1155666.
KEGGxac:XAC1595.
PATRIC24055189. VBIXanAxo33670_1673.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0061.
HOGENOMHOG000139847.
KOK00858.
OMAHESTVSI.
OrthoDBEOG6PZXDR.

Enzyme and pathway databases

BioCycXAXO190486:GH55-1595-MONOMER.

Family and domain databases

Gene3D2.60.200.30. 1 hit.
3.40.50.10330. 1 hit.
HAMAPMF_00361. NAD_kinase.
InterProIPR017438. ATP-NAD_kinase_dom_1.
IPR016064. ATP-NAD_kinase_PpnK-typ.
IPR017437. ATP-NAD_kinase_PpnK-typ_all-b.
IPR002504. PolyP/ATP_NADK.
[Graphical view]
PANTHERPTHR20275. PTHR20275. 1 hit.
PfamPF01513. NAD_kinase. 1 hit.
[Graphical view]
SUPFAMSSF111331. SSF111331. 1 hit.
ProtoNetSearch...

Entry information

Entry nameNADK_XANAC
AccessionPrimary (citable) accession number: Q8PM39
Entry history
Integrated into UniProtKB/Swiss-Prot: October 25, 2002
Last sequence update: October 25, 2002
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families