Reviewed, UniProtKB/Swiss-Prot Q8PM34 (KMO_XANAC)

Names and origin

Protein names

Recommended name:
    Kynurenine 3-monooxygenase
    EC=1.14.13.9
Alternative name(s):
    Kynurenine 3-hydroxylase

Gene names

Name:	kmo
Ordered Locus Names:	XAC1600

Organism

Xanthomonas axonopodis pv. citri (Citrus canker) [Complete proteome] [HAMAP]

Taxonomic identifier

92829 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid By similarity.
Catalytic activity	L-kynurenine + NADPH + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O.
Cofactor	FAD By similarity.
Pathway	Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 1/3.
Sequence similarities	Belongs to the aromatic-ring hydroxylase family. KMO subfamily.

Ontologies

Keywords
Biological process	Pyridine nucleotide biosynthesis
Ligand	FAD Flavoprotein NADP
Molecular function	Monooxygenase Oxidoreductase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	oxidation reduction Inferred from electronic annotation. Source: UniProtKB-KW pyridine nucleotide biosynthetic process Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	kynurenine 3-monooxygenase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Kynurenine 3-monooxygenase		PRO_0000361946

Sequences

	Sequence		Length	Mass (Da)
	Q8PM34-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: D4D9F44E9761A618	FASTA	455	50,858
	10 20 30 40 50 60 MSPVSQRSLT LIGAGLAGCL LAILLSRRGW QVTVYERRGD PRIKGYESGR SINLALAERG 70 80 90 100 110 120 RHALRQAGAE DAVMAKAVMM RGRMVHPLVG QPQLQRYGRD DSEVIWSIHR AALNVALLDL 130 140 150 160 170 180 AEQAGARVHF YRRLHTVDFD AGYARFIDDR DDQPHEIHFQ SLIGSDGAGS ALRAAMQRKS 190 200 210 220 230 240 PLGERTEFLD HSYKELEIPP QPGGGFRIEG NALHIWPRGR YMCIALPNDG GTFTVTLFLP 250 260 270 280 290 300 NAGEPSFATT RTGDEAFALF ARDFPDALPL IPQLKEHWEE HPPGLLGTLT LDRWHLDGRA 310 320 330 340 350 360 LLIGDAAHAM VPFHGQGMNC AFEDCVALAD QLDAHDDLAS AFAAFEAARR DDAAAIQQMA 370 380 390 400 410 420 LENYLEMRDR VDDPDFLLQR ELEQQLQARW PTRFVPHYTM VTFLRTRYSI ALARSEIQRE 430 440 450 ILVQATRGHS DLSRIDWSAL EAVVHARLEP LDGAH

References

[1]

"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities." da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P. , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P. Nature 417:459-463(2002) [PubMed: 12024217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 306.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE008923 Genomic DNA. Translation: AAM36468.1.
RefSeq	NP_641932.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1155671.
GenomeReviews	Gene locus XAC1600 in contig AE008923_GR.
KEGG	xac:XAC1600.
NMPDR	fig|190486.1.peg.1576.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8PM34.
OMA	LHAIMPS.
Enzyme and pathway databases
BioCyc	XAXO190486:XAC1600-MON.
Family and domain databases
InterPro	IPR002938. mOase_FAD_bd. IPR003042. Rng_hydrolase-like. [Graphical view]
Pfam	PF01494. FAD_binding_3. 1 hit. [Graphical view]
PRINTS	PR00420. RNGMNOXGNASE.
ProtoNet	Search...

Entry information

Entry name

KMO_XANAC

Accession

Primary (citable) accession number: Q8PM34

Entry history

Integrated into UniProtKB/Swiss-Prot:	February 10, 2009
Last sequence update:	October 1, 2002
Last modified:	November 3, 2009
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)