Reviewed, UniProtKB/Swiss-Prot Q8PLL9 (XYLA1_XANAC)

Names and origin

Protein names

Recommended name:
    Xylose isomerase 1
    EC=5.3.1.5

Gene names

Name:	xylA1
Ordered Locus Names:	XAC1776

Organism

Xanthomonas axonopodis pv. citri (Citrus canker) [Complete proteome] [HAMAP]

Taxonomic identifier

92829 [NCBI]

Taxonomic lineage

Bacteria › Proteobacteria › Gammaproteobacteria › Xanthomonadales › Xanthomonadaceae › Xanthomonas

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	D-xylose = D-xylulose. HAMAP MF_00455
Cofactor	Binds 2 magnesium ions per subunit By similarity. HAMAP MF_00455
Subunit structure	Homotetramer By similarity. HAMAP MF_00455
Subcellular location	Cytoplasm By similarity HAMAP MF_00455.
Sequence similarities	Belongs to the xylose isomerase family.

Ontologies

Keywords
Biological process	Carbohydrate metabolism Pentose shunt Xylose metabolism
Cellular component	Cytoplasm
Ligand	Magnesium Metal-binding
Molecular function	Isomerase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	D-xylose metabolic process Inferred from electronic annotation. Source: HAMAP pentose-phosphate shunt Inferred from electronic annotation. Source: HAMAP
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	magnesium ion binding Inferred from electronic annotation. Source: HAMAP xylose isomerase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 441	441	Xylose isomerase 1 HAMAP MF_00455		PRO_0000195819
Sites
	Active site	105	1	By similarity
	Active site	108	1	By similarity
	Metal binding	236	1	Magnesium 1 By similarity
	Metal binding	272	1	Magnesium 1 By similarity
	Metal binding	272	1	Magnesium 2 By similarity
	Metal binding	275	1	Magnesium 2 By similarity
	Metal binding	300	1	Magnesium 1 By similarity
	Metal binding	311	1	Magnesium 2 By similarity
	Metal binding	313	1	Magnesium 2 By similarity
	Metal binding	343	1	Magnesium 1 By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8PLL9-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 379593D28F1D77A6	FASTA	441	48,367
	10 20 30 40 50 60 MYIGAKEYFP GIGKIGFEGR DSDNPLAFKV YDANKTIGDK TMAEHLRFAV AYWHSFCGNG 70 80 90 100 110 120 ADPFGPGTRA YPWDVGDTAL NRAEAKADAA FEFFTKLGVP YYCFHDIDLS PDADDITEYE 130 140 150 160 170 180 SNLKHMVGVA RQRQADTGIK LLWGTANLFS HPRYMNGAST NPDFNVVARA AVQVKAAIDA 190 200 210 220 230 240 TVALGGENYV FWGGREGYAC LHNTQMKREQ DNMARFLTLA RDYGRSIGFK GNFLIEPKPM 250 260 270 280 290 300 EPMKHQYDFD SATVIGFLRQ HGLDQDFKLN IEANHATLSG HSFEHDLQVA SDAGLLGSID 310 320 330 340 350 360 ANRGNAQNGW DTDQFPTDLY DTVGAMLVVL RQGGLAPGGL NFDAKVRRES SDPQDLFLAH 370 380 390 400 410 420 IGGMDAFARG LEVANALLTA SPLEQWRAER YASFDSGAGA DFAAGKTTLA DLAKHAAGNA 430 440 PQQISGRQEA YENLINQYLT R

References

[1]

"Comparison of the genomes of two Xanthomonas pathogens with differing host specificities." da Silva A.C.R., Ferro J.A., Reinach F.C., Farah C.S., Furlan L.R., Quaggio R.B., Monteiro-Vitorello C.B., Van Sluys M.A., Almeida N.F. Jr., Alves L.M.C., do Amaral A.M., Bertolini M.C., Camargo L.E.A., Camarotte G., Cannavan F., Cardozo J., Chambergo F., Ciapina L.P. , Cicarelli R.M.B., Coutinho L.L., Cursino-Santos J.R., El-Dorry H., Faria J.B., Ferreira A.J.S., Ferreira R.C.C., Ferro M.I.T., Formighieri E.F., Franco M.C., Greggio C.C., Gruber A., Katsuyama A.M., Kishi L.T., Leite R.P., Lemos E.G.M., Lemos M.V.F., Locali E.C., Machado M.A., Madeira A.M.B.N., Martinez-Rossi N.M., Martins E.C., Meidanis J., Menck C.F.M., Miyaki C.Y., Moon D.H., Moreira L.M., Novo M.T.M., Okura V.K., Oliveira M.C., Oliveira V.R., Pereira H.A., Rossi A., Sena J.A.D., Silva C., de Souza R.F., Spinola L.A.F., Takita M.A., Tamura R.E., Teixeira E.C., Tezza R.I.D., Trindade dos Santos M., Truffi D., Tsai S.M., White F.F., Setubal J.C., Kitajima J.P. Nature 417:459-463(2002) [PubMed: 12024217] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: 306.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE008923 Genomic DNA. Translation: AAM36640.1.
RefSeq	NP_642104.2.
3D structure databases
SMR	Q8PLL9. Positions 6-440.
ModBase	Search...
Genome annotation databases
GeneID	1155847.
GenomeReviews	Gene locus XAC1776 in contig AE008923_GR.
KEGG	xac:XAC1776.
NMPDR	fig|190486.1.peg.1748.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG297199.
Enzyme and pathway databases
BioCyc	XAXO190486:XAC1776-MONOMER.
BRENDA	5.3.1.5. 289771.
Family and domain databases
HAMAP	MF_00455. Xylose_isom_A. [Tree]
InterPro	IPR013022. Xyl_isomerase-like_TIM-brl. IPR012307. Xyl_isomerase_TIM-brl. IPR013452. Xylose_isom_bac. IPR001998. Xylose_isomerase. [Graphical view]
Gene3D	G3DSA:3.20.20.150. Xyl_isomerase-like_TIM-brl. 1 hit.
Pfam	PF01261. AP_endonuc_2. 1 hit. [Graphical view]
PRINTS	PR00688. XYLOSISMRASE.
TIGRFAMs	TIGR02630. xylose_isom_A. 1 hit.
PROSITE	PS51415. XYLOSE_ISOMERASE. 1 hit. [Graphical view]
ProtoNet	Search...

Entry information

Entry name

XYLA1_XANAC

Accession

Primary (citable) accession number: Q8PLL9

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2004
Last sequence update:	October 1, 2002
Last modified:	February 9, 2010
This is version 46 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)