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Q8PK32 (ARLY_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate lyase

Short name=ASAL
EC=4.3.2.1
Alternative name(s):
Arginosuccinase
Gene names
Name:argH
Ordered Locus Names:XAC2345
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length432 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

2-(N(omega)-L-arginino)succinate = fumarate + L-arginine. HAMAP-Rule MF_00006

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 3/3. HAMAP-Rule MF_00006

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00006.

Sequence similarities

Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.

Sequence caution

The sequence AAM37197.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   Molecular functionLyase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process via ornithine

Inferred from electronic annotation. Source: InterPro

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionargininosuccinate lyase activity

Inferred from electronic annotation. Source: UniProtKB-EC

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 432432Argininosuccinate lyase HAMAP-Rule MF_00006
PRO_0000137851

Sequences

Sequence LengthMass (Da)Tools
Q8PK32 [UniParc].

Last modified April 23, 2003. Version 2.
Checksum: FCF364479A1425A6

FASTA43246,393
        10         20         30         40         50         60 
MTNLLWQKPG VAVDAKIQSF LAGDDVILDR EFFLYDIAAS KAHAQGLQHI GILSLQELGG 

        70         80         90        100        110        120 
LSEQLDLLAA DFRSGAFVLD AQYEDCHSAI EARLTERLGD AGRKIHTGRS RNDQILVATR 

       130        140        150        160        170        180 
LWLKDKLQRV ATLSAEIAEV ALERAQAEAE LPVPGYTHIQ RAVVSSAGMW WAGWAEAFID 

       190        200        210        220        230        240 
NAVRAGDTVH LVDSNPLGTA AGYGVNLPLD RAHTTAELGF ARLLVSPIYA QLSRGKYELA 

       250        260        270        280        290        300 
ALEALGSATL DLRRIAWDLS LFTSGEFAFV ALPAQYTTGS SIMPNKRNPD VIELMRATHA 

       310        320        330        340        350        360 
SVAAARTEIE QLLSLPSGYH RDLQSSKGAI VHGFGRGLAA LELLPALLAN LEWRPDKLRA 

       370        380        390        400        410        420 
AIDSGMYATD VAVEAAVAGV PFREAYKAAA QASETAGQGR TPEGSLAARV SPGAAADLQL 

       430 
DVLQARWQAL RA 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM37197.1. Different initiation.
RefSeqNP_642661.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PK32.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC2345.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM37197; AAM37197; XAC2345.
GeneID1156416.
KEGGxac:XAC2345.
PATRIC24056759. VBIXanAxo33670_2442.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0165.
HOGENOMHOG000242744.
KOK01755.
OMACRKRVNV.
OrthoDBEOG6P5ZF8.
ProtClustDBPRK00855.

Enzyme and pathway databases

BioCycXAXO190486:GH55-2345-MONOMER.
UniPathwayUPA00068; UER00114.

Family and domain databases

Gene3D1.10.275.10. 1 hit.
HAMAPMF_00006. Arg_succ_lyase.
InterProIPR009049. Argininosuccinate_lyase.
IPR024083. Fumarase/histidase_N.
IPR020557. Fumarate_lyase_CS.
IPR000362. Fumarate_lyase_fam.
IPR022761. Fumarate_lyase_N.
IPR008948. L-Aspartase-like.
[Graphical view]
PANTHERPTHR11444. PTHR11444. 1 hit.
PTHR11444:SF3. PTHR11444:SF3. 1 hit.
PfamPF00206. Lyase_1. 1 hit.
[Graphical view]
PRINTSPR00149. FUMRATELYASE.
SUPFAMSSF48557. SSF48557. 1 hit.
PROSITEPS00163. FUMARATE_LYASES. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameARLY_XANAC
AccessionPrimary (citable) accession number: Q8PK32
Entry history
Integrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: April 23, 2003
Last modified: February 19, 2014
This is version 79 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways