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Q8PK26 (ASSY_XANAC) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 84. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Argininosuccinate synthase

EC=6.3.4.5
Alternative name(s):
Citrulline--aspartate ligase
Gene names
Name:argG
Ordered Locus Names:XAC2351
OrganismXanthomonas axonopodis pv. citri (strain 306) [Complete proteome] [HAMAP]
Taxonomic identifier190486 [NCBI]
Taxonomic lineageBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas

Protein attributes

Sequence length412 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + L-citrulline + L-aspartate = AMP + diphosphate + N(omega)-(L-arginino)succinate. HAMAP-Rule MF_00005

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis; L-arginine from L-ornithine and carbamoyl phosphate: step 2/3. HAMAP-Rule MF_00005

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00005

Subcellular location

Cytoplasm By similarity HAMAP-Rule MF_00005.

Sequence similarities

Belongs to the argininosuccinate synthase family. Type 1 subfamily.

Ontologies

Keywords
   Biological processAmino-acid biosynthesis
Arginine biosynthesis
   Cellular componentCytoplasm
   LigandATP-binding
Nucleotide-binding
   Molecular functionLigase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processarginine biosynthetic process

Inferred from electronic annotation. Source: UniProtKB-HAMAP

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

argininosuccinate synthase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 412412Argininosuccinate synthase HAMAP-Rule MF_00005
PRO_0000148666

Regions

Nucleotide binding24 – 329ATP By similarity

Sites

Binding site501ATP; via amide nitrogen and carbonyl oxygen By similarity
Binding site1031Citrulline By similarity
Binding site1081Citrulline By similarity
Binding site1321ATP; via amide nitrogen By similarity
Binding site1341Aspartate By similarity
Binding site1381Aspartate By similarity
Binding site1381Citrulline By similarity
Binding site1391Aspartate By similarity
Binding site1421Citrulline By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8PK26 [UniParc].

Last modified October 19, 2002. Version 1.
Checksum: 87B452E924F33A73

FASTA41244,901
        10         20         30         40         50         60 
MMSAASTNPE FPIATSGTKD IVLAFSGGLD TSFCIPYLQE RGYAVHTVFA DTGGVDAEER 

        70         80         90        100        110        120 
EFIEKRAAEL GAASHVTVDG GPAIWEGFVK PFVWAGEGYQ GQYPLLVSDR YLIVDAALKR 

       130        140        150        160        170        180 
AEELGTRIIA HGCTGMGNDQ VRFDLAVKAL GDYQIVAPIR EIQKEHTQTR AYEQKYLEAR 

       190        200        210        220        230        240 
GFGVRAKQQA YTINENLLGL TMSGGEIDRW EAPGEGARGW CAPRSAWPSE ALTVTLKFVE 

       250        260        270        280        290        300 
GEAVELDGKP LPGAKILAKL NTLFAQYGVG RGVYTGDTVI GLKGRIVFEA PGLISLLTAH 

       310        320        330        340        350        360 
RALEDAVLTK QQNRFKPDVA RKWVELVYEG FYHDPLKSDI EAFLKSSQAK VNGEVTLETR 

       370        380        390        400        410 
GGRVDAVAVR SPHLLNTKGA TYAQSADWGV EEAEGFIKLF GMSSTLYAQV NR 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AE008923 Genomic DNA. Translation: AAM37203.1.
RefSeqNP_642667.1. NC_003919.1.

3D structure databases

ProteinModelPortalQ8PK26.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING190486.XAC2351.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaAAM37203; AAM37203; XAC2351.
GeneID1156422.
KEGGxac:XAC2351.
PATRIC24056771. VBIXanAxo33670_2448.

Organism-specific databases

CMRSearch...

Phylogenomic databases

eggNOGCOG0137.
HOGENOMHOG000230095.
KOK01940.
OMAIYNGYWW.
OrthoDBEOG6K9QCV.
ProtClustDBPRK04527.

Enzyme and pathway databases

BioCycXAXO190486:GH55-2351-MONOMER.
UniPathwayUPA00068; UER00113.

Family and domain databases

Gene3D3.40.50.620. 1 hit.
3.90.1260.10. 1 hit.
HAMAPMF_00005. Arg_succ_synth_type1.
InterProIPR001518. Arginosuc_synth.
IPR018223. Arginosuc_synth_CS.
IPR023434. Arginosuc_synth_type_1_subfam.
IPR024074. AS_cat/multimer_dom_body.
IPR014729. Rossmann-like_a/b/a_fold.
[Graphical view]
PfamPF00764. Arginosuc_synth. 1 hit.
[Graphical view]
TIGRFAMsTIGR00032. argG. 1 hit.
PROSITEPS00564. ARGININOSUCCIN_SYN_1. 1 hit.
PS00565. ARGININOSUCCIN_SYN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameASSY_XANAC
AccessionPrimary (citable) accession number: Q8PK26
Entry history
Integrated into UniProtKB/Swiss-Prot: October 19, 2002
Last sequence update: October 19, 2002
Last modified: February 19, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

PATHWAY comments

Index of metabolic and biosynthesis pathways