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Protein

Glutamate--tRNA ligase

Gene

gltX

Organism
Xanthomonas axonopodis pv. citri (strain 306)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).UniRule annotation

Catalytic activityi

ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu).UniRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei240ATPUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionAminoacyl-tRNA synthetase, Ligase
Biological processProtein biosynthesis
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Glutamate--tRNA ligaseUniRule annotation (EC:6.1.1.17UniRule annotation)
Alternative name(s):
Glutamyl-tRNA synthetaseUniRule annotation
Short name:
GluRSUniRule annotation
Gene namesi
Name:gltXUniRule annotation
Synonyms:gluS
Ordered Locus Names:XAC2847
OrganismiXanthomonas axonopodis pv. citri (strain 306)
Taxonomic identifieri190486 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaXanthomonadalesXanthomonadaceaeXanthomonas
Proteomesi
  • UP000000576 Componenti: Chromosome

Subcellular locationi

  • Cytoplasm UniRule annotation

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197031 – 467Glutamate--tRNA ligaseAdd BLAST467

Interactioni

Subunit structurei

Monomer.UniRule annotation

Protein-protein interaction databases

STRINGi190486.XAC2847

Structurei

3D structure databases

ProteinModelPortaliQ8PIP8
SMRiQ8PIP8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 19"HIGH" regionUniRule annotationAdd BLAST11
Motifi237 – 241"KMSKS" regionUniRule annotation5

Sequence similaritiesi

Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105C20 Bacteria
COG0008 LUCA
HOGENOMiHOG000252722
KOiK01885
OMAiHYINTLP
OrthoDBiPOG091H021W

Family and domain databases

CDDicd00808 GluRS_core, 1 hit
Gene3Di1.10.10.350, 1 hit
3.40.50.620, 1 hit
HAMAPiMF_00022 Glu_tRNA_synth_type1, 1 hit
InterProiView protein in InterPro
IPR008925 aa-tRNA-synth_I_codon-bd
IPR020751 aa-tRNA-synth_I_codon-bd_sub2
IPR001412 aa-tRNA-synth_I_CS
IPR004527 Glu-tRNA-ligase_bac/mito
IPR000924 Glu/Gln-tRNA-synth
IPR020058 Glu/Gln-tRNA-synth_Ib_cat-dom
IPR033910 GluRS_core
IPR014729 Rossmann-like_a/b/a_fold
PfamiView protein in Pfam
PF00749 tRNA-synt_1c, 1 hit
PRINTSiPR00987 TRNASYNTHGLU
SUPFAMiSSF48163 SSF48163, 1 hit
TIGRFAMsiTIGR00464 gltX_bact, 1 hit
PROSITEiView protein in PROSITE
PS00178 AA_TRNA_LIGASE_I, 1 hit

Sequencei

Sequence statusi: Complete.

Q8PIP8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTCRTRFAPS PTGYLHIGGA RTALYCWLEA RHRGGQFVLR IEDTDRERST
60 70 80 90 100
QEAIDAILEA MDWLGLGYDE GPIYQTQRVA RYQEVAEQLL AQGKAYYAYE
110 120 130 140 150
TREELDAMRE AAMAKQEKPR YNGAAREQNL PYRDDPNRVI RFKNPVGGTV
160 170 180 190 200
VFDDLIKGRI EIANSELDDM VIFRPDGFPT YNFAVVVDDW DMGITEVIRG
210 220 230 240 250
DDHINNTPRQ INIYEALDAP VPKFAHMPMI LDEQGAKLSK RTGAADVMQY
260 270 280 290 300
KDAGYLPHAL INYLARLGWS HGDQELFTQQ ELLDLFDVKD VNSKAARLDM
310 320 330 340 350
AKLGWVNQHY LKTDDPASIA PQLEYQLAKL GVDIAAGPAA ADVVVALRER
360 370 380 390 400
VQTLKEMAEK AVVWYQPLET YDEAAVMKHL KLGAEVPLGK ARELLAAVDA
410 420 430 440 450
WSVESVSAAL HDAAAALELG MGKVAQPLRV AITGTQVSPD ISQTVYLAGR
460
EGALKRIDAA LIKIGAA
Length:467
Mass (Da):51,860
Last modified:October 1, 2002 - v1
Checksum:iE586A82872F9A6EA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AE008923 Genomic DNA Translation: AAM37692.1
RefSeqiWP_011051870.1, NC_003919.1

Genome annotation databases

EnsemblBacteriaiAAM37692; AAM37692; XAC2847
KEGGixac:XAC2847

Similar proteinsi

Entry informationi

Entry nameiSYE_XANAC
AccessioniPrimary (citable) accession number: Q8PIP8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 23, 2003
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health